Prediction of Preeclampsia by Combining Serum Histidine-Rich Glycoprotein and Uterine Artery Doppler

Bolin, MarieUppsala universitet,Obstetrik & gynekologi,Obstetrisk forskning/Axelsson (author)

BackgroundPreeclampsia is associated with both maternal and perinatal morbidity and mortality. Histidine-rich glycoprotein (HRG) is a protein interacting with angiogenesis, coagulation, and inflammatory responses, processes known to be altered in preeclamptic pregnancies. Significantly lower levels of HRG have been demonstrated as early as in the first trimester in women later developing preeclampsia compared with normal pregnancies. The aim of this study was to investigate whether the combination of HRG and uterine artery Doppler ultrasonography can be used as a predictor of preeclampsia.MethodsA total of 175 women were randomly selected from a case-control study; 86 women had an uncomplicated pregnancy and 89 women later developed preeclampsia. Blood samples and pulsatility index (PI) were obtained from both cases and controls in gestational week 14.ResultsHRG levels were significantly lower in women who developed preterm preeclampsia compared with controls, but not for women developing preeclampsia in general. PI was significantly higher in the preeclampsia group compared with controls, especially in preterm preeclampsia. The combination of HRG and PI revealed a sensitivity of 91% and a specificity of 62% for preterm preeclampsia.ConclusionsThe combination of HRG and uterine artery Doppler may predict preterm preeclampsia in early pregnancy.

Wikström, Anna-Karin,1965-Karolinska Institutet,Uppsala universitet,Obstetrik & gynekologi,Obstetrisk forskning/Axelsson(Swepub:uu)annwi179 (author)
Wiberg-Itzel, EvaKarolinska Institutet (author)
Olsson, Anna-KarinUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)annaolss (author)
Ringvall, MariaUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)mariring (author)
Sundström-Poromaa, IngerUppsala universitet,Obstetrik & gynekologi,Reproduktiv hälsa/Sundström Poromaa(Swepub:uu)inspo702 (author)
Axelsson, Ove,1944-Uppsala universitet,Obstetrik & gynekologi,Centrum för klinisk forskning i D län (CKFD),Obstetrisk forskning/Axelsson(Swepub:uu)oveaxels (author)
Thilaganathan, BaskyDivision of Clinical Development Sciences, Department of Obstetrics and Gynecology, St George’s University of London, England (author)
Åkerud, Helena,1972-Uppsala universitet,Obstetrik & gynekologi,Obstetrisk forskning/Axelsson(Swepub:uu)helelars (author)
Uppsala universitetObstetrik & gynekologi (creator_code:org_t)

In:American Journal of Hypertension: Oxford University Press (OUP)25:12, s. 1305-13100895-70611941-7225

By the author/editor: Bolin, Marie; Wikström, Anna-K ...; Wiberg-Itzel, Ev ...; Olsson, Anna-Kar ...; Ringvall, Maria; Sundström-Poroma ...; show more...; Axelsson, Ove, 1 ...; Thilaganathan, B ...; Åkerud, Helena, ...; show less...

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