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  • Faria, VandaUppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden (författare)

Amygdala Subregions Tied to SSRI and Placebo Response in Patients with Social Anxiety Disorder

  • Artikel/kapitelEngelska2012

Förlag, utgivningsår, omfång ...

  • 2012-05-23
  • Nature Publishing Group,2012
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-181544
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-181544URI
  • https://doi.org/10.1038/npp.2012.72DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-38898URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • The amygdala is a key structure in the pathophysiology of anxiety disorders, and a putative target for anxiolytic treatments, Selective serotonin reuptake inhibitors (SSRIs) and placebo seem to induce anxiolytic effects by attenuating amygdala responsiveness. However, conflicting amygdala findings have also been reported. Moreover, the neural profile of responders and nonresponders is insufficiently characterized and it remains unknown whether SSRIs and placebo engage common or distinct amygdala subregions or different modulatory cortical areas. We examined similarities and differences in the neural response to SSRIs and placebo in patients with social anxiety disorder (SAD). Positron emission tomography (PET) with oxygen-15-labeled water was used to assess regional cerebral blood flow (rCBF) in 72 patients with SAD during an anxiogenic public speaking task, before and after 6-8 weeks of treatment under double-blind conditions. Response rate was determined by the Clinical Global Impression-Improvement scale. Conjunction analysis revealed a common rCBF-attenuation from pre- to post-treatment in responders to SSRIs and placebo in the left basomedial/basolateral and right ventrolateral amygdala. This rCBF pattern con-elated with behavioral measures of reduced anxiety and differentiated responders from nonresponders. However, nonanxiolytic treatment effects were also observed in the amygdala. All subgroups, including nonresponders, showed deactivation of the left lateral part of the amygdala. No rCBF differences were found between SSRI responders and placebo responders. This study provides new insights into the brain dynamics underlying anxiety relief by demonstrating common amygdala targets for pharmacologically and psychologically induced anxiety reduction, and by showing that the amygdala is functionally heterogeneous in anxiolysis.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Appel, LieuweUppsala universitet,Enheten för nuklearmedicin och PET,Department of Nuclear Medicine and PET, Uppsala University, Uppsala University Hospital, Uppsala, Sweden(Swepub:uu)lap02157 (författare)
  • Åhs, FredrikUppsala universitet,Institutionen för psykologi,Department of Psychology and Neuroscience, Duke University, Durham, NC, USA,Department of Psychology and Neuroscience, Duke University, Durham, NC, United States(Swepub:miun)freahs (författare)
  • Linnman, ClasP.A.I.N. Group, Department of Anesthesia, Children's Hospital, Boston, MA, USA,P.A.I.N. Group, Department of Anesthesia, Childrens Hospital, Boston, MA, United States (författare)
  • Pissiota, AnnaUppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden (författare)
  • Frans, ÖrjanUppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden(Swepub:uu)orjafran (författare)
  • Bani, MassimoGlaxoSmithKline, Medicine Research Centre, Verona, Italy (författare)
  • Bettica, PaoloGlaxoSmithKline, Medicine Research Centre, Verona, Italy (författare)
  • M Pich, EmilioGlaxoSmithKline, Medicine Research Centre, Verona, Italy; F. Hoffman la Roche, Pharmaceutical Division, PRED, Basel, Switzerland (författare)
  • Jacobsson, EvaUppsala University Hospital and Quintiles AB Phase I Services, Uppsala, Sweden (författare)
  • Wahlsted, KurtUppsala University Hospital and Quintiles AB Phase I Services, Uppsala, Sweden (författare)
  • Fredrikson, MatsUppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden(Swepub:uu)matsfred (författare)
  • Furmark, TomasUppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden(Swepub:uu)tomafurm (författare)
  • Uppsala universitetInstitutionen för psykologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Neuropsychopharmacology: Nature Publishing Group37:10, s. 2222-22320893-133X1740-634X

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