Age, sex and NK1 receptors in the human brain: A positron emission tomography study with [C-11]GR205171

Engman, JonasUppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden (author)

Age, sex and NK1 receptors in the human brain : A positron emission tomography study with [C-11]GR205171

The substance P/neurokinin 1 (SP/NK1) system has been implicated in the processing of negative affect. Its role seems complex and findings from animal studies have not been easily translated to humans. Brain imaging studies on NK1 receptor distribution in humans have revealed an abundance of receptors in cortical, striatal and subcortical areas, including the amygdala. A reduction in NK1 receptors with increasing age has been reported in frontal, temporal, and parietal cortices, as well as in hippocampal areas. Also, a previous study suggests sex differences in cortical and subcortical areas, with women displaying fewer NK1 receptors. The present PET study explored NK1 receptor availability in men (n = 9) and women (n = 9) matched for age varying between 20 and 50 years using the highly specific NK1 receptor antagonist [11C]GR205171 and a reference tissue model with cerebellum as the reference region. Age by sex interactions in the amygdala and the temporal cortex reflected a lower NK1 receptor availability with increasing age in men, but not in women. A general age-related decline in NK1 receptor availability was evident in the frontal, temporal, and occipital cortices, as well as in the brainstem, caudate nucleus, and thalamus. Women had lower NK1 receptor availability in the thalamus. The observed pattern of NK1 receptor distribution in the brain might have functional significance for brain-related disorders showing age- and sex-related differences in prevalence.

Åhs, FredrikUppsala universitet,Institutionen för psykologi,Center for Cognitive Neuroscience, Duke University, Durham, NC, USA(Swepub:miun)freahs (author)
Furmark, TomasUppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden(Swepub:uu)tomafurm (author)
Linnman, ClasP.A.I.N. group, McLean Hospital/Harvard Medical School, Belmont, MA, USA (author)
Pissiota, AnnaUppsala universitet,Psykiatri, Akademiska sjukhuset,Department of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden (author)
Appel, LieuweUppsala universitet,Enheten för nuklearmedicin och PET,PET Centre, Department of Medical Imaging, Uppsala University Hospital, Sweden; Section of Nuclear Medicine and PET, Department of Radiology, Oncology, and Radiation Sciences, Uppsala University, Sweden(Swepub:uu)lap02157 (author)
Frans, ÖrjanUppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden(Swepub:uu)orjafran (author)
Långström, BengtUppsala universitet,Fysikalisk-organisk kemi,Department of Chemistry, Uppsala University, Uppsala, Sweden(Swepub:uu)benglang (author)
Fredrikson, MatsUppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden(Swepub:uu)matsfred (author)
Uppsala universitetInstitutionen för psykologi (creator_code:org_t)

In:European Neuropsychopharmacology: Elsevier BV22:8, s. 562-5680924-977X1873-7862

By the author/editor: Engman, Jonas; Åhs, Fredrik; Furmark, Tomas; Linnman, Clas; Pissiota, Anna; Appel, Lieuwe; show more...; Frans, Örjan; Långström, Bengt; Fredrikson, Mats; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

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