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  • van Assema, Danielle M. E. (author)

No evidence for additional blood-brain barrier P-glycoprotein dysfunction in Alzheimer's disease patients with microbleeds

  • Article/chapterEnglish2012

Publisher, publication year, extent ...

  • 2012-05-16
  • SAGE Publications,2012
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-181876
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-181876URI
  • https://doi.org/10.1038/jcbfm.2012.64DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Decreased blood-brain barrier P-glycoprotein (Pgp) function has been shown in Alzheimer's disease (AD) patients using positron emission tomography (PET) with the radiotracer (R)-[C-11] verapamil. Decreased Pgp function has also been hypothesized to promote cerebral amyloid angiopathy (CAA) development. Here, we used PET and (R)-[C-11] verapamil to assess Pgp function in eighteen AD patients, of which six had microbleeds (MBs), presumably reflecting underlying CAA. No differences were found in binding potential and nonspecific volume of distribution of (R)-[C-11] verapamil between patient groups. These results provide no evidence for additional Pgp dysfunction in AD patients with MBs.

Subject headings and genre

  • Alzheimer's disease
  • blood-brain barrier
  • cerebral amyloid angiopathy
  • P-glycoprotein
  • positron emission tomography
  • (R)-[C-11]verapamil

Added entries (persons, corporate bodies, meetings, titles ...)

  • Goos, Jeroen D. C. (author)
  • van der Flier, Wiesje M. (author)
  • Lubberink, MarkUppsala universitet,Enheten för nuklearmedicin och PET(Swepub:uu)marklubb (author)
  • Boellaard, Ronald (author)
  • Windhorst, Albert D. (author)
  • Scheltens, Philip (author)
  • Lammertsma, Adriaan A. (author)
  • van Berckel, Bart N. M. (author)
  • Uppsala universitetEnheten för nuklearmedicin och PET (creator_code:org_t)

Related titles

  • In:Journal of Cerebral Blood Flow and Metabolism: SAGE Publications32:8, s. 1468-14710271-678X1559-7016

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