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Sökning: id:"swepub:oai:DiVA.org:uu-182015" > Essential polyunsat...

  • Huang, Xiaoyan (författare)

Essential polyunsaturated fatty acids, inflammation and mortality in dialysis patients

  • Artikel/kapitelEngelska2012

Förlag, utgivningsår, omfång ...

  • 2012-05-07
  • Oxford University Press (OUP),2012
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-182015
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-182015URI
  • https://doi.org/10.1093/ndt/gfs132DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-190847URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:125739380URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:125145030URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background. Polyunsaturated fatty acids (PUFA) are essential nutrients with anti-inflammatory and cardioprotective properties. We investigated the association of essential dietary PUFA intake, reflected by plasma fatty acid composition, with inflammation and mortality in dialysis patients.Methods. We recruited 222 Swedish dialysis subjects (39% women) with median age of 57 years and average 12 months of dialysis vintage. Plasma phospholipid PUFA were assessed by gas-liquid chromatography. Overall mortality was assessed after 18.4 (10th-90th percentiles: 2.3-60) months of follow-up.Results. Linoleic acid (LA), Mead acid (MA), alpha-linolenic acid (ALA) and long-chain n-3 PUFA (LC n-3; the sum of eicosapentaenoic, docosapentaenoic and docosahexaenoic acids) represented 19.7, 0.26, 0.26 and 7.64% of all fatty acids in plasma, respectively. This may reflect an adequate n-3 PUFA intake. LA was negatively (beta = -0.21, P = 0.004) but MA positively (beta = 0.25, P < 0.001) associated with interleukin (IL)-6 in multivariate analyses. Neither ALA nor LC n-3 were independently associated with IL-6. During follow-up, 61 deaths and 115 kidney transplants occurred. Fully adjusted competing risk models showed that every percent increase in the proportion of plasma LA was associated with 12% reduction in mortality risk before transplantation (hazard ratio 0.88, 95% confidence interval 0.79-0.99). MA was directly associated with mortality. Neither ALA nor LC n-3 predicted outcome.Conclusions. The proportion of plasma phospholipid LA is inversely associated with IL-6 and all-cause mortality in Swedish dialysis patients. We raise the hypothesis that dialysis patients could benefit from increased intake of vegetable oils, the primary source of LA in the Western-type diet.

Ämnesord och genrebeteckningar

  • competing risk models
  • end-stage renal disease
  • inflammation
  • mortality
  • polyunsaturated fatty acids

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Stenvinkel, PeterKarolinska Institutet (författare)
  • Qureshi, Abdul RashidKarolinska Institutet (författare)
  • Risérus, UlfUppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)ulfriser (författare)
  • Cederholm, TommyKarolinska Institutet,Uppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)tomce419 (författare)
  • Barany, PeterKarolinska Institutet (författare)
  • Heimburger, OlofKarolinska Institutet (författare)
  • Lindholm, BengtKarolinska Institutet (författare)
  • Carrero, Juan JesusKarolinska Institutet (författare)
  • Karolinska InstitutetKlinisk nutrition och metabolism (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Nephrology, Dialysis and Transplantation: Oxford University Press (OUP)27:9, s. 3615-36200931-05091460-2385

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