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Application of the ...
Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens
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Fogg, M. J. (author)
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Alzari, P. (author)
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Bahar, M. (author)
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show more...
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Bertini, I. (author)
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Betton, J. M. (author)
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Burmeister, W. P. (author)
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Cambillau, C. (author)
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Canard, B. (author)
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Carrondo, M. (author)
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Coll, M. (author)
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Daenke, S. (author)
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Dym, O. (author)
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Egloff, M. P. (author)
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Enguita, F. J. (author)
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Geerlof, A. (author)
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Haouz, A. (author)
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- Jones, T. Alwyn (author)
- Uppsala universitet,Strukturell molekylärbiologi
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Ma, Qingjun (author)
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Manicka, S. N. (author)
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Migliardi, M. (author)
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- Nordlund, P. (author)
- Karolinska Institutet
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Owens, R. J. (author)
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Peleg, Y. (author)
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- Schneider, G. (author)
- Karolinska Institutet
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- Schnell, R. (author)
- Karolinska Institutet
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Stuart, D. I. (author)
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Tarbouriech, N. (author)
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- Unge, Torsten (author)
- Uppsala universitet,Strukturell molekylärbiologi
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Wilkinson, A. J. (author)
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Wilmanns, M. (author)
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Wilson, K. S. (author)
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Zimhony, O. (author)
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Grimes, J. M. (author)
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(creator_code:org_t)
- 2006
- 2006
- English.
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In: Acta Crystallographica Section D. - 0907-4449 .- 1399-0047. ; 62:10, s. 1196-1207
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The Structural Proteomics In Europe (SPINE) programme is aimed at the development and implementation of high-throughput technologies for the efficient structure determination of proteins of biomedical importance, such as those of bacterial and viral pathogens linked to human health. Despite the challenging nature of some of these targets, 175 novel pathogen protein structures (approximately 220 including complexes) have been determined to date. Here the impact of several technologies on the structural determination of proteins from human pathogens is illustrated with selected examples, including the parallel expression of multiple constructs, the use of standardized refolding protocols and optimized crystallization screens.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Automation
- Bacteria
- Cloning
- Expression
- Miniaturization
- Viruses
- Cell and molecular biology
- Cell- och molekylärbiologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Fogg, M. J.
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Alzari, P.
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Bahar, M.
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Bertini, I.
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Betton, J. M.
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Burmeister, W. P ...
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show more...
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Cambillau, C.
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Canard, B.
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Carrondo, M.
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Coll, M.
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Daenke, S.
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Dym, O.
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Egloff, M. P.
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Enguita, F. J.
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Geerlof, A.
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Haouz, A.
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Jones, T. Alwyn
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Ma, Qingjun
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Manicka, S. N.
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Migliardi, M.
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Nordlund, P.
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Owens, R. J.
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Peleg, Y.
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Schneider, G.
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Schnell, R.
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Stuart, D. I.
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Tarbouriech, N.
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Unge, Torsten
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Wilkinson, A. J.
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Wilmanns, M.
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Wilson, K. S.
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Zimhony, O.
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Grimes, J. M.
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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Acta Crystallogr ...
- By the university
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Uppsala University
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Karolinska Institutet