Search: (WFRF:(Campbell Ian)) pers:(Rudan Igor) pers:(Morris Andrew P.) pers:(Spector Tim D.) >
Large-scale associa...
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
-
Scott, Robert A. (author)
-
Lagou, Vasiliki (author)
-
Welch, Ryan P. (author)
-
show more...
-
Wheeler, Eleanor (author)
-
Montasser, May E. (author)
-
Luan, Jian'an (author)
-
Maegi, Reedik (author)
-
- Strawbridge, Rona J. (author)
- Karolinska Institutet
-
Rehnberg, Emil (author)
-
Gustafsson, Stefan (author)
-
Kanoni, Stavroula (author)
-
Rasmussen-Torvik, Laura J. (author)
-
Yengo, Loic (author)
-
Lecoeur, Cecile (author)
-
- Shungin, Dmitry (author)
- Umeå universitet,Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Institutionen för odontologi,Medicin
-
Sanna, Serena (author)
-
Sidore, Carlo (author)
-
Johnson, Paul C. D. (author)
-
Jukema, J. Wouter (author)
-
Johnson, Toby (author)
-
Mahajan, Anubha (author)
-
Verweij, Niek (author)
-
Thorleifsson, Gudmar (author)
-
Hottenga, Jouke-Jan (author)
-
Shah, Sonia (author)
-
Smith, Albert V. (author)
-
- Sennblad, Bengt (author)
- Karolinska Institutet
-
Gieger, Christian (author)
-
Salo, Perttu (author)
-
Perola, Markus (author)
-
Timpson, Nicholas J. (author)
-
Evans, David M. (author)
-
St Pourcain, Beate (author)
-
Wu, Ying (author)
-
Andrews, Jeanette S. (author)
-
Hui, Jennie (author)
-
Bielak, Lawrence F. (author)
-
Zhao, Wei (author)
-
Horikoshi, Momoko (author)
-
Navarro, Pau (author)
-
Isaacs, Aaron (author)
-
O'Connell, Jeffrey R. (author)
-
Stirrups, Kathleen (author)
-
- V Varga, Tibor (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
-
Hayward, Caroline (author)
-
Esko, Tonu (author)
-
Mihailov, Evelin (author)
-
Fraser, Ross M. (author)
-
- Fall, Tove, 1979- (author)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
-
Voight, Benjamin F. (author)
-
Raychaudhuri, Soumya (author)
-
Chen, Han (author)
-
Lindgren, Cecilia M. (author)
-
Morris, Andrew P. (author)
-
Rayner, Nigel W. (author)
-
Robertson, Neil (author)
-
Rybin, Denis (author)
-
Liu, Ching-Ti (author)
-
Beckmann, Jacques S. (author)
-
Willems, Sara M. (author)
-
Chines, Peter S. (author)
-
Jackson, Anne U. (author)
-
Kang, Hyun Min (author)
-
Stringham, Heather M. (author)
-
Song, Kijoung (author)
-
Tanaka, Toshiko (author)
-
Peden, John F. (author)
-
Goel, Anuj (author)
-
Hicks, Andrew A. (author)
-
An, Ping (author)
-
Mueller-Nurasyid, Martina (author)
-
- Franco-Cereceda, Anders (author)
- Karolinska Institutet
-
Folkersen, Lasse (author)
-
Marullo, Letizia (author)
-
Jansen, Hanneke (author)
-
Oldehinkel, Albertine J. (author)
-
Bruinenberg, Marcel (author)
-
Pankow, James S. (author)
-
North, Kari E. (author)
-
Forouhi, Nita G. (author)
-
Loos, Ruth J. F. (author)
-
Edkins, Sarah (author)
-
Varga, Tibor V. (author)
-
- Hallmans, Göran, 1947- (author)
- Umeå universitet,Näringsforskning
-
Oksa, Heikki (author)
-
Antonella, Mulas (author)
-
Nagaraja, Ramaiah (author)
-
Trompet, Stella (author)
-
Ford, Ian (author)
-
- Lind, Lars (author)
- Karolinska Institutet,Uppsala universitet,Kardiovaskulär epidemiologi
-
Kong, Augustine (author)
-
Kumari, Meena (author)
-
- Gigante, Bruna (author)
- Karolinska Institutet
-
Herder, Christian (author)
-
Munroe, Patricia B. (author)
-
Caulfield, Mark (author)
-
Antti, Jula (author)
-
Mangino, Massimo (author)
-
Small, Kerrin (author)
-
Miljkovic, Iva (author)
-
Liu, Yongmei (author)
-
Atalay, Mustafa (author)
-
Kiess, Wieland (author)
-
James, Alan L. (author)
-
Rivadeneira, Fernando (author)
-
Uitterlinden, Andre G. (author)
-
Palmer, Colin N. A. (author)
-
Doney, Alex S. F. (author)
-
Willemsen, Gonneke (author)
-
Smit, Johannes H. (author)
-
Campbell, Susan (author)
-
Polasek, Ozren (author)
-
Bonnycastle, Lori L. (author)
-
Hercberg, Serge (author)
-
Dimitriou, Maria (author)
-
Bolton, Jennifer L. (author)
-
Fowkes, Gerard R. (author)
-
- Kovacs, Peter (author)
- Karolinska Institutet
-
Lindstrom, Jaana (author)
-
Zemunik, Tatijana (author)
-
Bandinelli, Stefania (author)
-
Wild, Sarah H. (author)
-
Basart, Hanneke V. (author)
-
Rathmann, Wolfgang (author)
-
Grallert, Harald (author)
-
Maerz, Winfried (author)
-
Kleber, Marcus E. (author)
-
Boehm, Bernhard O. (author)
-
Peters, Annette (author)
-
Pramstaller, Peter P. (author)
-
Province, Michael A. (author)
-
Borecki, Ingrid B. (author)
-
Hastie, Nicholas D. (author)
-
Rudan, Igor (author)
-
Campbell, Harry (author)
-
Watkins, Hugh (author)
-
Farrall, Martin (author)
-
Stumvoll, Michael (author)
-
Ferrucci, Luigi (author)
-
Waterworth, Dawn M. (author)
-
Bergman, Richard N. (author)
-
Collins, Francis S. (author)
-
Tuomilehto, Jaakko (author)
-
Watanabe, Richard M. (author)
-
de Geus, Eco J. C. (author)
-
Penninx, Brenda W. (author)
-
Hofman, Albert (author)
-
Oostra, Ben A. (author)
-
Psaty, Bruce M. (author)
-
Vollenweider, Peter (author)
-
Wilson, James F. (author)
-
Wright, Alan F. (author)
-
Hovingh, G. Kees (author)
-
Metspalu, Andres (author)
-
Uusitupa, Matti (author)
-
Magnusson, Patrik K. E. (author)
-
Kyvik, Kirsten O. (author)
-
Kaprio, Jaakko (author)
-
Price, Jackie F. (author)
-
Dedoussis, George V. (author)
-
Deloukas, Panos (author)
-
Meneton, Pierre (author)
-
- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
-
Boehnke, Michael (author)
-
Shuldiner, Alan R. (author)
-
van Duijn, Cornelia M. (author)
-
Morris, Andrew D. (author)
-
Toenjes, Anke (author)
-
Peyser, Patricia A. (author)
-
Beilby, John P. (author)
-
Koerner, Antje (author)
-
Kuusisto, Johanna (author)
-
Laakso, Markku (author)
-
Bornstein, Stefan R. (author)
-
Schwarz, Peter E. H. (author)
-
Lakka, Timo A. (author)
-
Rauramaa, Rainer (author)
-
Adair, Linda S. (author)
-
Smith, George Davey (author)
-
Spector, Tim D. (author)
-
Illig, Thomas (author)
-
- de Faire, Ulf (author)
- Karolinska Institutet
-
- Hamsten, Anders (author)
- Karolinska Institutet
-
Gudnason, Vilmundur (author)
-
Kivimaki, Mika (author)
-
Hingorani, Aroon (author)
-
Keinanen-Kiukaanniemi, Sirkka M. (author)
-
Saaristo, Timo E. (author)
-
Boomsma, Dorret I. (author)
-
Stefansson, Kari (author)
-
van der Harst, Pim (author)
-
Dupuis, Josee (author)
-
Pedersen, Nancy L. (author)
-
Sattar, Naveed (author)
-
Harris, Tamara B. (author)
-
Cucca, Francesco (author)
-
Ripatti, Samuli (author)
-
Salomaa, Veikko (author)
-
Mohlke, Karen L. (author)
-
Balkau, Beverley (author)
-
Froguel, Philippe (author)
-
Pouta, Anneli (author)
-
Jarvelin, Marjo-Riitta (author)
-
Wareham, Nicholas J. (author)
-
Bouatia-Naji, Nabila (author)
-
McCarthy, Mark I. (author)
-
- Franks, Paul (author)
- Umeå universitet,Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Medicin
-
Meigs, James B. (author)
-
Teslovich, Tanya M. (author)
-
Florez, Jose C. (author)
-
Langenberg, Claudia (author)
-
- Ingelsson, Erik (author)
- Karolinska Institutet
-
Prokopenko, Inga (author)
-
Barroso, Ines (author)
-
show less...
-
(creator_code:org_t)
- 2012-08-12
- 2012
- English.
-
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:9, s. 991-1005
- Related links:
-
https://pure.mpg.de/...
-
show more...
-
http://dx.doi.org/10...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
http://kipublication...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q < 0.05). Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on insulin resistance. Gene-based analyses identified further biologically plausible loci, suggesting that additional loci beyond those reaching genome-wide significance are likely to represent real associations. This conclusion is supported by an excess of directionally consistent and nominally significant signals between discovery and follow-up studies. Functional analysis of these newly discovered loci will further improve our understanding of glycemic control.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Scott, Robert A.
-
Lagou, Vasiliki
-
Welch, Ryan P.
-
Wheeler, Eleanor
-
Montasser, May E ...
-
Luan, Jian'an
-
show more...
-
Maegi, Reedik
-
Strawbridge, Ron ...
-
Rehnberg, Emil
-
Gustafsson, Stef ...
-
Kanoni, Stavroul ...
-
Rasmussen-Torvik ...
-
Yengo, Loic
-
Lecoeur, Cecile
-
Shungin, Dmitry
-
Sanna, Serena
-
Sidore, Carlo
-
Johnson, Paul C. ...
-
Jukema, J. Woute ...
-
Johnson, Toby
-
Mahajan, Anubha
-
Verweij, Niek
-
Thorleifsson, Gu ...
-
Hottenga, Jouke- ...
-
Shah, Sonia
-
Smith, Albert V.
-
Sennblad, Bengt
-
Gieger, Christia ...
-
Salo, Perttu
-
Perola, Markus
-
Timpson, Nichola ...
-
Evans, David M.
-
St Pourcain, Bea ...
-
Wu, Ying
-
Andrews, Jeanett ...
-
Hui, Jennie
-
Bielak, Lawrence ...
-
Zhao, Wei
-
Horikoshi, Momok ...
-
Navarro, Pau
-
Isaacs, Aaron
-
O'Connell, Jeffr ...
-
Stirrups, Kathle ...
-
V Varga, Tibor
-
Hayward, Carolin ...
-
Esko, Tonu
-
Mihailov, Evelin
-
Fraser, Ross M.
-
Fall, Tove, 1979 ...
-
Voight, Benjamin ...
-
Raychaudhuri, So ...
-
Chen, Han
-
Lindgren, Cecili ...
-
Morris, Andrew P ...
-
Rayner, Nigel W.
-
Robertson, Neil
-
Rybin, Denis
-
Liu, Ching-Ti
-
Beckmann, Jacque ...
-
Willems, Sara M.
-
Chines, Peter S.
-
Jackson, Anne U.
-
Kang, Hyun Min
-
Stringham, Heath ...
-
Song, Kijoung
-
Tanaka, Toshiko
-
Peden, John F.
-
Goel, Anuj
-
Hicks, Andrew A.
-
An, Ping
-
Mueller-Nurasyid ...
-
Franco-Cereceda, ...
-
Folkersen, Lasse
-
Marullo, Letizia
-
Jansen, Hanneke
-
Oldehinkel, Albe ...
-
Bruinenberg, Mar ...
-
Pankow, James S.
-
North, Kari E.
-
Forouhi, Nita G.
-
Loos, Ruth J. F.
-
Edkins, Sarah
-
Varga, Tibor V.
-
Hallmans, Göran, ...
-
Oksa, Heikki
-
Antonella, Mulas
-
Nagaraja, Ramaia ...
-
Trompet, Stella
-
Ford, Ian
-
Lind, Lars
-
Kong, Augustine
-
Kumari, Meena
-
Gigante, Bruna
-
Herder, Christia ...
-
Munroe, Patricia ...
-
Caulfield, Mark
-
Antti, Jula
-
Mangino, Massimo
-
Small, Kerrin
-
Miljkovic, Iva
-
Liu, Yongmei
-
Atalay, Mustafa
-
Kiess, Wieland
-
James, Alan L.
-
Rivadeneira, Fer ...
-
Uitterlinden, An ...
-
Palmer, Colin N. ...
-
Doney, Alex S. F ...
-
Willemsen, Gonne ...
-
Smit, Johannes H ...
-
Campbell, Susan
-
Polasek, Ozren
-
Bonnycastle, Lor ...
-
Hercberg, Serge
-
Dimitriou, Maria
-
Bolton, Jennifer ...
-
Fowkes, Gerard R ...
-
Kovacs, Peter
-
Lindstrom, Jaana
-
Zemunik, Tatijan ...
-
Bandinelli, Stef ...
-
Wild, Sarah H.
-
Basart, Hanneke ...
-
Rathmann, Wolfga ...
-
Grallert, Harald
-
Maerz, Winfried
-
Kleber, Marcus E ...
-
Boehm, Bernhard ...
-
Peters, Annette
-
Pramstaller, Pet ...
-
Province, Michae ...
-
Borecki, Ingrid ...
-
Hastie, Nicholas ...
-
Rudan, Igor
-
Campbell, Harry
-
Watkins, Hugh
-
Farrall, Martin
-
Stumvoll, Michae ...
-
Ferrucci, Luigi
-
Waterworth, Dawn ...
-
Bergman, Richard ...
-
Collins, Francis ...
-
Tuomilehto, Jaak ...
-
Watanabe, Richar ...
-
de Geus, Eco J. ...
-
Penninx, Brenda ...
-
Hofman, Albert
-
Oostra, Ben A.
-
Psaty, Bruce M.
-
Vollenweider, Pe ...
-
Wilson, James F.
-
Wright, Alan F.
-
Hovingh, G. Kees
-
Metspalu, Andres
-
Uusitupa, Matti
-
Magnusson, Patri ...
-
Kyvik, Kirsten O ...
-
Kaprio, Jaakko
-
Price, Jackie F.
-
Dedoussis, Georg ...
-
Deloukas, Panos
-
Meneton, Pierre
-
Boehnke, Michael
-
Shuldiner, Alan ...
-
van Duijn, Corne ...
-
Morris, Andrew D ...
-
Toenjes, Anke
-
Peyser, Patricia ...
-
Beilby, John P.
-
Koerner, Antje
-
Kuusisto, Johann ...
-
Laakso, Markku
-
Bornstein, Stefa ...
-
Schwarz, Peter E ...
-
Lakka, Timo A.
-
Rauramaa, Rainer
-
Adair, Linda S.
-
Smith, George Da ...
-
Spector, Tim D.
-
Illig, Thomas
-
de Faire, Ulf
-
Hamsten, Anders
-
Gudnason, Vilmun ...
-
Kivimaki, Mika
-
Hingorani, Aroon
-
Keinanen-Kiukaan ...
-
Saaristo, Timo E ...
-
Boomsma, Dorret ...
-
Stefansson, Kari
-
van der Harst, P ...
-
Dupuis, Josee
-
Pedersen, Nancy ...
-
Sattar, Naveed
-
Harris, Tamara B ...
-
Cucca, Francesco
-
Ripatti, Samuli
-
Salomaa, Veikko
-
Mohlke, Karen L.
-
Balkau, Beverley
-
Froguel, Philipp ...
-
Pouta, Anneli
-
Jarvelin, Marjo- ...
-
Wareham, Nichola ...
-
Bouatia-Naji, Na ...
-
McCarthy, Mark I ...
-
Franks, Paul
-
Meigs, James B.
-
Teslovich, Tanya ...
-
Florez, Jose C.
-
Langenberg, Clau ...
-
Ingelsson, Erik
-
Prokopenko, Inga
-
Barroso, Ines
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Genetics
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Public Health Gl ...
- Articles in the publication
-
Nature Genetics
- By the university
-
Uppsala University
-
Lund University
-
Karolinska Institutet
-
Umeå University