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Large-scale associa...
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
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Scott, Robert A. (author)
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Lagou, Vasiliki (author)
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Welch, Ryan P. (author)
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show more...
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Wheeler, Eleanor (author)
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Montasser, May E. (author)
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Luan, Jian'an (author)
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Maegi, Reedik (author)
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- Strawbridge, Rona J. (author)
- Karolinska Institutet
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Rehnberg, Emil (author)
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Gustafsson, Stefan (author)
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Kanoni, Stavroula (author)
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Rasmussen-Torvik, Laura J. (author)
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Yengo, Loic (author)
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Lecoeur, Cecile (author)
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- Shungin, Dmitry (author)
- Umeå universitet,Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Institutionen för odontologi,Medicin
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Sanna, Serena (author)
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Sidore, Carlo (author)
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Johnson, Paul C. D. (author)
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Jukema, J. Wouter (author)
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Johnson, Toby (author)
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Mahajan, Anubha (author)
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Verweij, Niek (author)
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Thorleifsson, Gudmar (author)
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Hottenga, Jouke-Jan (author)
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Shah, Sonia (author)
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Smith, Albert V. (author)
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- Sennblad, Bengt (author)
- Karolinska Institutet
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Gieger, Christian (author)
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Salo, Perttu (author)
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Perola, Markus (author)
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Timpson, Nicholas J. (author)
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Evans, David M. (author)
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St Pourcain, Beate (author)
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Wu, Ying (author)
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Andrews, Jeanette S. (author)
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Hui, Jennie (author)
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Bielak, Lawrence F. (author)
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Zhao, Wei (author)
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Horikoshi, Momoko (author)
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Navarro, Pau (author)
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Isaacs, Aaron (author)
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O'Connell, Jeffrey R. (author)
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Stirrups, Kathleen (author)
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- V Varga, Tibor (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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Hayward, Caroline (author)
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Esko, Tonu (author)
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Mihailov, Evelin (author)
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Fraser, Ross M. (author)
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- Fall, Tove, 1979- (author)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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Voight, Benjamin F. (author)
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Raychaudhuri, Soumya (author)
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Chen, Han (author)
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Lindgren, Cecilia M. (author)
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Morris, Andrew P. (author)
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Rayner, Nigel W. (author)
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Robertson, Neil (author)
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Rybin, Denis (author)
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Liu, Ching-Ti (author)
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Beckmann, Jacques S. (author)
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Willems, Sara M. (author)
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Chines, Peter S. (author)
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Jackson, Anne U. (author)
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Kang, Hyun Min (author)
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Stringham, Heather M. (author)
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Song, Kijoung (author)
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Tanaka, Toshiko (author)
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Peden, John F. (author)
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Goel, Anuj (author)
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Hicks, Andrew A. (author)
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An, Ping (author)
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Mueller-Nurasyid, Martina (author)
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- Franco-Cereceda, Anders (author)
- Karolinska Institutet
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Folkersen, Lasse (author)
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Marullo, Letizia (author)
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Jansen, Hanneke (author)
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Oldehinkel, Albertine J. (author)
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Bruinenberg, Marcel (author)
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Pankow, James S. (author)
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North, Kari E. (author)
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Forouhi, Nita G. (author)
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Loos, Ruth J. F. (author)
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Edkins, Sarah (author)
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Varga, Tibor V. (author)
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- Hallmans, Göran, 1947- (author)
- Umeå universitet,Näringsforskning
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Oksa, Heikki (author)
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Antonella, Mulas (author)
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Nagaraja, Ramaiah (author)
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Trompet, Stella (author)
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Ford, Ian (author)
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- Lind, Lars (author)
- Karolinska Institutet,Uppsala universitet,Kardiovaskulär epidemiologi
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Kong, Augustine (author)
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Kumari, Meena (author)
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- Gigante, Bruna (author)
- Karolinska Institutet
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Herder, Christian (author)
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Munroe, Patricia B. (author)
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Caulfield, Mark (author)
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Antti, Jula (author)
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Mangino, Massimo (author)
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Small, Kerrin (author)
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Miljkovic, Iva (author)
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Liu, Yongmei (author)
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Atalay, Mustafa (author)
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Kiess, Wieland (author)
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James, Alan L. (author)
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Rivadeneira, Fernando (author)
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Uitterlinden, Andre G. (author)
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Palmer, Colin N. A. (author)
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Doney, Alex S. F. (author)
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Willemsen, Gonneke (author)
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Smit, Johannes H. (author)
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Campbell, Susan (author)
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Polasek, Ozren (author)
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Bonnycastle, Lori L. (author)
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Hercberg, Serge (author)
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Dimitriou, Maria (author)
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Bolton, Jennifer L. (author)
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Fowkes, Gerard R. (author)
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- Kovacs, Peter (author)
- Karolinska Institutet
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Lindstrom, Jaana (author)
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Zemunik, Tatijana (author)
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Bandinelli, Stefania (author)
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Wild, Sarah H. (author)
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Basart, Hanneke V. (author)
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Rathmann, Wolfgang (author)
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Grallert, Harald (author)
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Maerz, Winfried (author)
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Kleber, Marcus E. (author)
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Boehm, Bernhard O. (author)
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Peters, Annette (author)
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Pramstaller, Peter P. (author)
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Province, Michael A. (author)
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Borecki, Ingrid B. (author)
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Hastie, Nicholas D. (author)
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Rudan, Igor (author)
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Campbell, Harry (author)
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Watkins, Hugh (author)
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Farrall, Martin (author)
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Stumvoll, Michael (author)
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Ferrucci, Luigi (author)
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Waterworth, Dawn M. (author)
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Bergman, Richard N. (author)
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Collins, Francis S. (author)
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Tuomilehto, Jaakko (author)
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Watanabe, Richard M. (author)
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de Geus, Eco J. C. (author)
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Penninx, Brenda W. (author)
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Hofman, Albert (author)
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Oostra, Ben A. (author)
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Psaty, Bruce M. (author)
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Vollenweider, Peter (author)
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Wilson, James F. (author)
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Wright, Alan F. (author)
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Hovingh, G. Kees (author)
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Metspalu, Andres (author)
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Uusitupa, Matti (author)
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Magnusson, Patrik K. E. (author)
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Kyvik, Kirsten O. (author)
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Kaprio, Jaakko (author)
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Price, Jackie F. (author)
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Dedoussis, George V. (author)
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Deloukas, Panos (author)
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Meneton, Pierre (author)
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
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Boehnke, Michael (author)
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Shuldiner, Alan R. (author)
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van Duijn, Cornelia M. (author)
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Morris, Andrew D. (author)
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Toenjes, Anke (author)
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Peyser, Patricia A. (author)
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Beilby, John P. (author)
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Koerner, Antje (author)
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Kuusisto, Johanna (author)
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Laakso, Markku (author)
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Bornstein, Stefan R. (author)
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Schwarz, Peter E. H. (author)
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Lakka, Timo A. (author)
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Rauramaa, Rainer (author)
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Adair, Linda S. (author)
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Smith, George Davey (author)
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Spector, Tim D. (author)
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Illig, Thomas (author)
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- de Faire, Ulf (author)
- Karolinska Institutet
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- Hamsten, Anders (author)
- Karolinska Institutet
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Gudnason, Vilmundur (author)
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Kivimaki, Mika (author)
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Hingorani, Aroon (author)
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Keinanen-Kiukaanniemi, Sirkka M. (author)
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Saaristo, Timo E. (author)
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Boomsma, Dorret I. (author)
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Stefansson, Kari (author)
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van der Harst, Pim (author)
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Dupuis, Josee (author)
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Pedersen, Nancy L. (author)
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Sattar, Naveed (author)
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Harris, Tamara B. (author)
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Cucca, Francesco (author)
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Ripatti, Samuli (author)
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Salomaa, Veikko (author)
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Mohlke, Karen L. (author)
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Balkau, Beverley (author)
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Froguel, Philippe (author)
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Pouta, Anneli (author)
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Jarvelin, Marjo-Riitta (author)
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Wareham, Nicholas J. (author)
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Bouatia-Naji, Nabila (author)
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McCarthy, Mark I. (author)
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- Franks, Paul (author)
- Umeå universitet,Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine,Medicin
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Meigs, James B. (author)
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Teslovich, Tanya M. (author)
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Florez, Jose C. (author)
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Langenberg, Claudia (author)
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- Ingelsson, Erik (author)
- Karolinska Institutet
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Prokopenko, Inga (author)
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Barroso, Ines (author)
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(creator_code:org_t)
- 2012-08-12
- 2012
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 44:9, s. 991-1005
- Related links:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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Abstract
Subject headings
Close
- Through genome-wide association meta-analyses of up to 133,010 individuals of European ancestry without diabetes, including individuals newly genotyped using the Metabochip, we have increased the number of confirmed loci influencing glycemic traits to 53, of which 33 also increase type 2 diabetes risk (q < 0.05). Loci influencing fasting insulin concentration showed association with lipid levels and fat distribution, suggesting impact on insulin resistance. Gene-based analyses identified further biologically plausible loci, suggesting that additional loci beyond those reaching genome-wide significance are likely to represent real associations. This conclusion is supported by an excess of directionally consistent and nominally significant signals between discovery and follow-up studies. Functional analysis of these newly discovered loci will further improve our understanding of glycemic control.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Scott, Robert A.
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Lagou, Vasiliki
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Welch, Ryan P.
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Wheeler, Eleanor
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Montasser, May E ...
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Luan, Jian'an
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show more...
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Maegi, Reedik
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Strawbridge, Ron ...
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Rehnberg, Emil
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Gustafsson, Stef ...
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Kanoni, Stavroul ...
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Rasmussen-Torvik ...
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Yengo, Loic
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Lecoeur, Cecile
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Shungin, Dmitry
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Sanna, Serena
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Sidore, Carlo
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Johnson, Paul C. ...
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Jukema, J. Woute ...
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Johnson, Toby
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Mahajan, Anubha
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Verweij, Niek
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Thorleifsson, Gu ...
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Hottenga, Jouke- ...
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Shah, Sonia
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Smith, Albert V.
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Sennblad, Bengt
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Gieger, Christia ...
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Salo, Perttu
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Perola, Markus
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Timpson, Nichola ...
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Evans, David M.
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St Pourcain, Bea ...
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Wu, Ying
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Andrews, Jeanett ...
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Hui, Jennie
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Bielak, Lawrence ...
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Zhao, Wei
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Horikoshi, Momok ...
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Navarro, Pau
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Isaacs, Aaron
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O'Connell, Jeffr ...
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Stirrups, Kathle ...
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V Varga, Tibor
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Hayward, Carolin ...
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Esko, Tonu
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Mihailov, Evelin
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Fraser, Ross M.
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Fall, Tove, 1979 ...
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Voight, Benjamin ...
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Raychaudhuri, So ...
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Chen, Han
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Lindgren, Cecili ...
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Morris, Andrew P ...
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Rayner, Nigel W.
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Robertson, Neil
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Rybin, Denis
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Liu, Ching-Ti
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Beckmann, Jacque ...
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Willems, Sara M.
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Chines, Peter S.
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Jackson, Anne U.
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Kang, Hyun Min
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Stringham, Heath ...
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Song, Kijoung
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Tanaka, Toshiko
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Peden, John F.
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Goel, Anuj
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Hicks, Andrew A.
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An, Ping
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Mueller-Nurasyid ...
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Franco-Cereceda, ...
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Folkersen, Lasse
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Marullo, Letizia
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Jansen, Hanneke
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Oldehinkel, Albe ...
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Bruinenberg, Mar ...
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Pankow, James S.
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North, Kari E.
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Forouhi, Nita G.
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Loos, Ruth J. F.
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Edkins, Sarah
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Varga, Tibor V.
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Hallmans, Göran, ...
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Oksa, Heikki
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Antonella, Mulas
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Nagaraja, Ramaia ...
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Trompet, Stella
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Ford, Ian
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Lind, Lars
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Kong, Augustine
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Kumari, Meena
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Gigante, Bruna
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Herder, Christia ...
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Munroe, Patricia ...
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Caulfield, Mark
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Antti, Jula
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Mangino, Massimo
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Small, Kerrin
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Miljkovic, Iva
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Liu, Yongmei
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Atalay, Mustafa
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Kiess, Wieland
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James, Alan L.
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Rivadeneira, Fer ...
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Uitterlinden, An ...
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Palmer, Colin N. ...
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Doney, Alex S. F ...
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Willemsen, Gonne ...
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Smit, Johannes H ...
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Campbell, Susan
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Polasek, Ozren
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Bonnycastle, Lor ...
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Hercberg, Serge
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Dimitriou, Maria
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Bolton, Jennifer ...
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Fowkes, Gerard R ...
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Kovacs, Peter
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Lindstrom, Jaana
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Zemunik, Tatijan ...
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Bandinelli, Stef ...
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Wild, Sarah H.
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Basart, Hanneke ...
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Rathmann, Wolfga ...
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Grallert, Harald
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Maerz, Winfried
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Kleber, Marcus E ...
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Boehm, Bernhard ...
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Peters, Annette
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Pramstaller, Pet ...
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Province, Michae ...
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Borecki, Ingrid ...
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Hastie, Nicholas ...
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Rudan, Igor
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Campbell, Harry
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Watkins, Hugh
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Farrall, Martin
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Stumvoll, Michae ...
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Ferrucci, Luigi
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Waterworth, Dawn ...
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Bergman, Richard ...
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Collins, Francis ...
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Tuomilehto, Jaak ...
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Watanabe, Richar ...
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de Geus, Eco J. ...
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Penninx, Brenda ...
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Hofman, Albert
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Oostra, Ben A.
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Psaty, Bruce M.
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Vollenweider, Pe ...
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Wilson, James F.
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Wright, Alan F.
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Hovingh, G. Kees
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Metspalu, Andres
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Uusitupa, Matti
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Magnusson, Patri ...
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Kyvik, Kirsten O ...
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Kaprio, Jaakko
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Price, Jackie F.
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Dedoussis, Georg ...
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Deloukas, Panos
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Meneton, Pierre
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Boehnke, Michael
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Shuldiner, Alan ...
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van Duijn, Corne ...
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Morris, Andrew D ...
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Toenjes, Anke
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Peyser, Patricia ...
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Beilby, John P.
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Koerner, Antje
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Kuusisto, Johann ...
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Laakso, Markku
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Bornstein, Stefa ...
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Schwarz, Peter E ...
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Lakka, Timo A.
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Rauramaa, Rainer
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Adair, Linda S.
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Smith, George Da ...
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Spector, Tim D.
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Illig, Thomas
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de Faire, Ulf
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Hamsten, Anders
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Gudnason, Vilmun ...
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Kivimaki, Mika
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Hingorani, Aroon
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Keinanen-Kiukaan ...
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Saaristo, Timo E ...
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Boomsma, Dorret ...
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Stefansson, Kari
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van der Harst, P ...
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Dupuis, Josee
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Pedersen, Nancy ...
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Sattar, Naveed
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Harris, Tamara B ...
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Cucca, Francesco
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Ripatti, Samuli
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Salomaa, Veikko
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Mohlke, Karen L.
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Balkau, Beverley
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Froguel, Philipp ...
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Pouta, Anneli
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Jarvelin, Marjo- ...
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Wareham, Nichola ...
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Bouatia-Naji, Na ...
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McCarthy, Mark I ...
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Franks, Paul
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Meigs, James B.
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Teslovich, Tanya ...
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Florez, Jose C.
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Langenberg, Clau ...
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Ingelsson, Erik
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Prokopenko, Inga
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Barroso, Ines
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
- Articles in the publication
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Nature Genetics
- By the university
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Uppsala University
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Lund University
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Karolinska Institutet
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Umeå University