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Modeling of red blo...
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Lledo-Garcia, RocioUppsala universitet,Institutionen för farmaceutisk biovetenskap
(författare)
Modeling of red blood cell life-spans in hematologically normal populations
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
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2012-07-31
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Springer Science and Business Media LLC,2012
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-183213
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-183213URI
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https://doi.org/10.1007/s10928-012-9261-5DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Despite the impact of red blood cell (RBC) Life-spans in some disease areas such as diabetes or anemia of chronic kidney disease, there is no consensus on how to quantitatively best describe the process. Several models have been proposed to explain the elimination process of RBCs: random destruction process, homogeneous life-span model, or a series of 4-transit compartment model. The aim of this work was to explore the different models that have been proposed in literature, and modifications to those. The impact of choosing the right model on future outcomes prediction-in the above mentioned areas- was also investigated. Both data from indirect (clinical data) and direct life-span measurement (biotin-labeled data) methods were analyzed using non-linear mixed effects models. Analysis showed that: (1) predictions from non-steady state data will depend on the RBC model chosen; (2) the transit compartment model, which considers variation in life-span in the RBC population, better describes RBC survival data than the random destruction or homogenous life-span models; and (3) the additional incorporation of random destruction patterns, although improving the description of the RBC survival data, does not appear to provide a marked improvement when describing clinical data.
Ämnesord och genrebeteckningar
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Life-span modeling
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Red blood cells
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Hba1c
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Pharmacometrics
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Biotin labeled
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Mechanism-based model
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Kalicki, Robert M.Uppsala universitet,Institutionen för farmaceutisk biovetenskap
(författare)
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Uehlinger, Dominik E.
(författare)
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Karlsson, Mats O.Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Farmakometri(Swepub:uu)matskarl
(författare)
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Uppsala universitetInstitutionen för farmaceutisk biovetenskap
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Pharmacokinetics and Pharmacodynamics: Springer Science and Business Media LLC39:5, s. 453-4621567-567X1573-8744
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