Search: id:"swepub:oai:DiVA.org:uu-184603" >
Intranasal Treatmen...
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Chapman, Colin DUppsala universitet,Funktionell farmakologi
(author)
Intranasal Treatment of Central Nervous System Dysfunction in Humans
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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2012-11-08
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Springer Science and Business Media LLC,2013
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-184603
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-184603URI
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https://doi.org/10.1007/s11095-012-0915-1DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:for swepub-publicationtype
Notes
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One of the most challenging problems facing modern medicine is how to deliver a given drug to a specific target at the exclusion of other regions. For example, a variety of compounds have beneficial effects within the central nervous system (CNS), but unwanted side effects in the periphery. For such compounds, traditional oral or intravenous drug delivery fails to provide benefit without cost. However, intranasal delivery is emerging as a noninvasive option for delivering drugs to the CNS with minimal peripheral exposure. Additionally, this method facilitates the delivery of large and/or charged therapeutics, which fail to effectively cross the blood-brain barrier (BBB). Thus, for a variety of growth factors, hormones, neuropeptides and therapeutics including insulin, oxytocin, orexin, and even stem cells, intranasal delivery is emerging as an efficient method of administration, and represents a promising therapeutic strategy for the treatment of diseases with CNS involvement, such as obesity, Alzheimer's disease, Parkinson's disease, Huntington's disease, depression, anxiety, autism spectrum disorders, seizures, drug addiction, eating disorders, and stroke.
Added entries (persons, corporate bodies, meetings, titles ...)
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Frey, William H
(author)
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Craft, Suzanne
(author)
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Danielyan, Lusine
(author)
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Hallschmid, Manfred
(author)
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Schiöth, Helgi BUppsala universitet,Funktionell farmakologi(Swepub:uu)helgschi
(author)
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Benedict, ChristianUppsala universitet,Funktionell farmakologi(Swepub:uu)chrbe136
(author)
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Uppsala universitetFunktionell farmakologi
(creator_code:org_t)
Related titles
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In:Pharmaceutical research: Springer Science and Business Media LLC30:10, s. 2475-24840724-87411573-904X
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