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d-amino acid oxidas...
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Andreou, DimitriosKarolinska Institutet
(författare)
d-amino acid oxidase activator gene (DAOA) variation affects cerebrospinal fluid homovanillic acid concentrations in healthy Caucasians
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
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2012-03-28
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Springer Science and Business Media LLC,2012
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-184639
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-184639URI
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https://doi.org/10.1007/s00406-012-0313-zDOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:125398140URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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The d-amino acid oxidase activator (DAOA) protein regulates the function of d-amino oxidase (DAO), an enzyme that catalyzes the oxidative deamination of d-3,4-dihydroxyphenylalanine (D-DOPA) and d-serine. D-DOPA is converted to l-3,4-DOPA, a precursor of dopamine, whereas d-serine participates in glutamatergic transmission. We hypothesized that DAOA polymorphisms are associated with dopamine, serotonin and noradrenaline turnover in the human brain. Four single-nucleotide polymorphisms, previously reported to be associated with schizophrenia, were genotyped. Cerebrospinal fluid (CSF) samples were drawn by lumbar puncture, and the concentrations of the major dopamine metabolite homovanillic acid (HVA), the major serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) and the major noradrenaline metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) were measured. Two of the investigated polymorphisms, rs3918342 and rs1421292, were significantly associated with CSF HVA concentrations. Rs3918342 was found to be nominally associated with CSF 5-HIAA concentrations. None of the polymorphisms were significantly associated with MHPG concentrations. Our results indicate that DAOA gene variation affects dopamine turnover in healthy individuals, suggesting that disturbed dopamine turnover is a possible mechanism behind the observed associations between genetic variation in DAOA and behavioral phenotypes in humans.
Ämnesord och genrebeteckningar
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D-amino acid oxidase activator gene (DAOA)
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Cerebrospinal fluid (CSF)
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Homovanillic acid (HVA)
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5-hydroxyindoleacetic acid (5-HIAA)
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3-methoxy-4-hydroxyphenylglycol (MHPG)
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Saetre, Peter
(författare)
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Werge, Thomas
(författare)
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Andreassen, Ole A.
(författare)
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Agartz, IngridKarolinska Institutet
(författare)
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Sedvall, Göran C.
(författare)
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Hall, HåkanUppsala universitet,Geriatrik,Plattformen för preklinisk PET(Swepub:uu)hakha923
(författare)
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Terenius, LarsKarolinska Institutet
(författare)
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Jonsson, Erik G.Karolinska Institutet
(författare)
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Karolinska InstitutetGeriatrik
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Archives of Psychiatry and Clinical Neuroscience: Springer Science and Business Media LLC262:7, s. 549-5560940-13341433-8491
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