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Elevated Plasma Lev...
Elevated Plasma Levels of Arginines During Labor Among Women with Spontaneous Preterm Birth : A Prospective Cohort Study
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- Akhter, Tansim, 1967- (författare)
- Uppsala universitet,Klinisk obstetrik
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- Hedeland, Mikael (författare)
- Uppsala universitet,Analytisk farmaceutisk kemi
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- Bergquist, Jonas (författare)
- Uppsala universitet,Analytisk kemi
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- Ubhayasekera, Kumari (författare)
- Uppsala universitet,Analytisk kemi
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- Larsson, Anders (författare)
- Uppsala universitet,Klinisk kemi
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- Bystrom, Ludvig (författare)
- Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning
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- Kullinger, Merit (författare)
- Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning,Centrum för klinisk forskning, Västerås
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- Skalkidou, Alkistis, 1977- (författare)
- Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning
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(creator_code:org_t)
- John Wiley & Sons, 2024
- 2024
- Engelska.
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Ingår i: American Journal of Reproductive Immunology. - : John Wiley & Sons. - 1046-7408 .- 1600-0897. ; 91:6
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Problem: Preterm birth (PTB) is a leading cause of infant mortality and morbidity. The pathogenesis of PTB is complex and involves many factors, including socioeconomy, inflammation and infection. Asymmetric dimethylarginine, ADMA and symmetric dimethylarginine, SDMA are involved in labor as inhibitors of nitric oxide, a known relaxant of the uterine smooth muscles. Arginines are scarcely studied in relation to PTB and we aimed to investigate arginines (ADMA, SDMA and L-arginine) in women with spontaneous PTB and term birth.Methods of the Study: The study was based on data from the population-based, prospective cohort BASIC study conducted in Uppsala County, Sweden, between September 2009 and November 2018. Arginines were analyzed by Ultra-High Performance Liquid Chromatography using plasma samples taken at the onset of labor from women with spontaneous PTB (n = 34) and term birth (n = 45). We also analyzed the inflammation markers CRP, TNF-R1 and TNF-R2 and GDF-15.Results: Women with spontaneous PTB had higher plasma levels of ADMA (p < 0.001), and L-Arginine (p = 0.03). In addition, inflammation marker, TNF-R1 (p = 0.01) was higher in spontaneous PTB compared to term birth. Further, in spontaneous PTB, no significant correlations could be observed when comparing levels of arginines with inflammation markers, except ADMA versus CRP.Conclusions: These findings provide novel evidence for the potential involvement of arginines in the pathogenesis of spontaneous PTB and it seems that arginine levels at labor vary independently of several inflammatory markers. Further research is warranted to investigate the potential of arginines as therapeutic targets in the prevention and management of spontaneous PTB.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- dimethylarginine
- inflammation marker
- L-arginine
- preterm birth
- preterm labor
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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