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Apolipoprotein E ep...
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Wohlin, MartinUppsala universitet,Geriatrik
(författare)
Apolipoprotein E epsilon 4 genotype is independently associated with increased intima-media thickness in a recessive pattern
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
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2007-04-11
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Wiley,2007
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-97039
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-97039URI
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https://doi.org/10.1007/s11745-007-3045-5DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Polymorphisms in the apolipoprotein E (Apo E) gene have been associated with lipid levels, carotid intima media thickness (CCA-IMT), inflammation and cardiovascular disease (CVD). Earlier findings suggested an association of the Apo E alleles with increased CCA-IMT following a recessive pattern. Whether associations might be independent of C-reactive protein (CRP), lipid levels and other CVD risk factors is not known. We investigated the relationships between Apo E (epsilon2, epsilon3 and epsilon4 alleles) and CCA-IMT, measured by B-mode ultrasound, in dominant and recessive models in a community-based sample of 437 men 75 years of age. In men homozygous for the epsilon4 allele CCA-IMT was significantly increased by 0.13 mm to 0.86 +/- 0.16 mm compared to 0.73 +/- 0.19 mm in non- epsilon4-carriers (P = 0.0012) and 0.73 +/- 0.21 mm in epsilon4 heterozygous (P = 0.0044) in unadjusted recessive models. The association between Apo E epsilon4 genotype and CCA-IMT was independent of Apo E epsilon2 and Apo E epsilon3 alleles, CRP, lipid variables (TG, LDL, HDL) and other CVD risk factors (smoking, hypertension, body mass index, diabetes) (P = 0.018). No relations between Apo E genotype and CCA-IMT were observed in dominant models. No significant associations between the Apo E epsilon2 and epsilon3 alleles and CCA-IMT were found. In this study, men homozygous with the ApoE epsilon4 allele had thicker CCA-IMT, independently of Apo E epsilon2 and epsilon3 alleles, CRP, lipid variables (TG, LDL, HDL) and other CVD risk factors (smoking, hypertension, body mass index, diabetes), suggesting CCA-IMT to be modified by the ApoE epsilon4 genotype in a recessive pattern.
Ämnesord och genrebeteckningar
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Apolipoprotein E
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Carotid
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Genotype
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Intima-media
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Ultrasound
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Sundström, JohanUppsala universitet,Geriatrik(Swepub:uu)johasund
(författare)
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Lannfelt, LarsUppsala universitet,Geriatrik(Swepub:uu)lalan021
(författare)
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Axelsson, TomasUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)toaxe957
(författare)
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Syvänen, Ann-ChristineUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)anncsyva
(författare)
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Andrén, BertilUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)bertand
(författare)
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Basu, SamarUppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)samabasu
(författare)
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Lind, LarsUppsala universitet,Institutionen för medicinska vetenskaper(Swepub:uu)larslind
(författare)
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Uppsala universitetGeriatrik
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Lipids: Wiley42:5, s. 451-4560024-42011558-9307
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