Association between Chlamydia pneumoniae antibodies and wheezing in young children and the influence of sex

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Wettergren Björn) > Association between...

Details
MARC

Normann, ErikUppsala universitet,Institutionen för kvinnors och barns hälsa,Allmänpediatrisk forskning/Nordvall (author)

Association between Chlamydia pneumoniae antibodies and wheezing in young children and the influence of sex

Article/chapterEnglish2006

Publisher, publication year, extent ...

BMJ,2006
printrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:uu-18828
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-18828URI
https://doi.org/10.1136/thx.2005.051656DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:1934017URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

BACKGROUND: The proposed association between Chlamydia pneumoniae (Cpn) infection and wheezing needs further clarification. METHODS: Serum samples obtained from 1581 children aged 4 years in a population based cohort were tested for antibodies to Cpn and IgE antibodies to common allergens. Data on environmental factors and disease were collected prospectively from birth. RESULTS: The occurrence of IgG antibodies to Cpn at 4 years of age was associated with reported wheezing at different ages; however, these findings were most often not significant. In girls, the occurrence of anti-Cpn IgG was associated with wheezing at the ages of 1, 2, and 4 years (odds ratios (ORs) 3.41 (95% confidence interval (CI) 1.46 to 7.96), 2.13 (95% CI 1.02 to 4.44), and 2.01 (95% CI 1.14 to 3.54), respectively), and even higher ORs were observed for each age category when only high level antibody responses to Cpn were analysed. At the time of blood sampling the association between anti-Cpn IgG and wheezing was restricted to girls without atopic sensitisation (OR 2.39 (95% CI 1.25 to 4.57). No associations with wheezing were detected in boys, in whom IgE sensitisation was inversely associated with the presence of anti-Cpn IgG (OR 0.49 (95% CI 0.26 to 0.90)). CONCLUSIONS: This study suggests an association between evidence of earlier Cpn infection and a history of wheezing in young girls. Infection with Cpn may be an important risk factor for wheezing and possibly for non-atopic asthma, predominantly in girls.

Subject headings and genre

MEDICINE
MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

Gnarpe, J. (author)
Wettergren, BjörnUppsala universitet,Institutionen för kvinnors och barns hälsa,Allmänpediatrisk forskning/Nordvall(Swepub:uu)bjwet676 (author)
Janson, ChristerUppsala universitet,Lungmedicin och allergologi(Swepub:uu)chrisjn (author)
Wickman, M.Karolinska Institutet (author)
Nordvall, LennartUppsala universitet,Institutionen för kvinnors och barns hälsa,Allmänpediatrisk forskning/Nordvall(Swepub:uu)lennnord (author)
Uppsala universitetInstitutionen för kvinnors och barns hälsa (creator_code:org_t)

Related titles

In:Thorax: BMJ61:12, s. 1054-10580040-63761468-3296

Internet link

Find in a library

Thorax (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Normann, Erik; Gnarpe, J.; Wettergren, Björ ...; Janson, Christer; Wickman, M.; Nordvall, Lennar ...

Articles in the publication: Thorax

By the university: Uppsala University; Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se