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Absolute Quantifica...
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van der Veldt, Astrid A M
(author)
Absolute Quantification of [11C]docetaxel Kinetics in Lung Cancer Patients Using Positron Emission Tomography
- Article/chapterEnglish2011
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LIBRIS-ID:oai:DiVA.org:uu-189076
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-189076URI
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https://doi.org/10.1158/1078-0432.CCR-10-2933DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Purpose:Tumor resistance to docetaxel may be associated with reduced drug concentrations in tumor tissue. Positron emission tomography (PET) allows for quantification of radiolabeled docetaxel ([11C]docetaxel) kinetics and might be useful for predicting response to therapy. The primary objective was to evaluate the feasibility of quantitative [11C]docetaxel PET scans in lung cancer patients. The secondary objective was to investigate whether [11C]docetaxel kinetics were associated with tumor perfusion, tumor size, and dexamethasone administration.Experimental Design:Thirty-four lung cancer patients underwent dynamic PET–computed tomography (CT) scans using [11C]docetaxel. Blood flow was measured using oxygen-15 labeled water. The first 24 patients were premedicated with dexamethasone. For quantification of [11C]docetaxel kinetics, the optimal tracer kinetic model was developed and a noninvasive procedure was validated.Results:Reproducible quantification of [11C]docetaxel kinetics in tumors was possible using a noninvasive approach (image derived input function). Thirty-two lesions (size ≥4 cm3) were identified, having a variable net influx rate of [11C]docetaxel (range, 0.0023–0.0229 mL·cm−3·min−1). [11C]docetaxel uptake was highly related to tumor perfusion (Spearman's ρ = 0.815;P < 0.001), but not to tumor size (Spearman's ρ = −0.140; P = 0.446). Patients pretreated with dexamethasone showed lower [11C]docetaxel uptake in tumors (P = 0.013). Finally, in a subgroup of patients who subsequently received docetaxel therapy, relative high [11C]docetaxel uptake was related with improved tumor response.Conclusions:Quantification of [11C]docetaxel kinetics in lung cancer was feasible in a clinical setting. Variable [11C]docetaxel kinetics in tumors may reflect differential sensitivity to docetaxel therapy. Our findings warrant further studies investigating the predictive value of [11C]docetaxel uptake and the effects of comedication on [11C]docetaxel kinetics in tumors.
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Lubberink, MarkDepartment of Nuclear Medicine & PET Research, VU University Medical Center, Amsterdam, The Netherlands(Swepub:uu)marklubb
(author)
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Greuter, Henri N
(author)
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Comans, Emile F I
(author)
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Herder, Gerarda J M
(author)
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Yaqub, Maqsood
(author)
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Schuit, Robert C
(author)
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van Lingen, Arthur
(author)
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Rizvi, S Nafees
(author)
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Mooijer, Martien P J
(author)
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Rijnders, Anneloes Y
(author)
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Windhorst, Albert D
(author)
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Smit, Egbert F
(author)
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Hendrikse, N Harry
(author)
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Lammertsma, Adriaan A
(author)
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Department of Nuclear Medicine & PET Research, VU University Medical Center, Amsterdam, The Netherlands
(creator_code:org_t)
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In:Clinical Cancer Research17:14, s. 4814-48241078-04321557-3265
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van der Veldt, A ...
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Lubberink, Mark
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Greuter, Henri N
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Comans, Emile F ...
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Yaqub, Maqsood
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Schuit, Robert C
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van Lingen, Arth ...
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Rizvi, S Nafees
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Windhorst, Alber ...
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Smit, Egbert F
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Uppsala University