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  • van der Veldt, Astrid A M (author)

Absolute Quantification of [11C]docetaxel Kinetics in Lung Cancer Patients Using Positron Emission Tomography

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2011
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-189076
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-189076URI
  • https://doi.org/10.1158/1078-0432.CCR-10-2933DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Purpose:Tumor resistance to docetaxel may be associated with reduced drug concentrations in tumor tissue. Positron emission tomography (PET) allows for quantification of radiolabeled docetaxel ([11C]docetaxel) kinetics and might be useful for predicting response to therapy. The primary objective was to evaluate the feasibility of quantitative [11C]docetaxel PET scans in lung cancer patients. The secondary objective was to investigate whether [11C]docetaxel kinetics were associated with tumor perfusion, tumor size, and dexamethasone administration.Experimental Design:Thirty-four lung cancer patients underwent dynamic PET–computed tomography (CT) scans using [11C]docetaxel. Blood flow was measured using oxygen-15 labeled water. The first 24 patients were premedicated with dexamethasone. For quantification of [11C]docetaxel kinetics, the optimal tracer kinetic model was developed and a noninvasive procedure was validated.Results:Reproducible quantification of [11C]docetaxel kinetics in tumors was possible using a noninvasive approach (image derived input function). Thirty-two lesions (size ≥4 cm3) were identified, having a variable net influx rate of [11C]docetaxel (range, 0.0023–0.0229 mL·cm−3·min−1). [11C]docetaxel uptake was highly related to tumor perfusion (Spearman's ρ = 0.815;P < 0.001), but not to tumor size (Spearman's ρ = −0.140; P = 0.446). Patients pretreated with dexamethasone showed lower [11C]docetaxel uptake in tumors (P = 0.013). Finally, in a subgroup of patients who subsequently received docetaxel therapy, relative high [11C]docetaxel uptake was related with improved tumor response.Conclusions:Quantification of [11C]docetaxel kinetics in lung cancer was feasible in a clinical setting. Variable [11C]docetaxel kinetics in tumors may reflect differential sensitivity to docetaxel therapy. Our findings warrant further studies investigating the predictive value of [11C]docetaxel uptake and the effects of comedication on [11C]docetaxel kinetics in tumors.

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  • Lubberink, MarkDepartment of Nuclear Medicine & PET Research, VU University Medical Center, Amsterdam, The Netherlands(Swepub:uu)marklubb (author)
  • Greuter, Henri N (author)
  • Comans, Emile F I (author)
  • Herder, Gerarda J M (author)
  • Yaqub, Maqsood (author)
  • Schuit, Robert C (author)
  • van Lingen, Arthur (author)
  • Rizvi, S Nafees (author)
  • Mooijer, Martien P J (author)
  • Rijnders, Anneloes Y (author)
  • Windhorst, Albert D (author)
  • Smit, Egbert F (author)
  • Hendrikse, N Harry (author)
  • Lammertsma, Adriaan A (author)
  • Department of Nuclear Medicine & PET Research, VU University Medical Center, Amsterdam, The Netherlands (creator_code:org_t)

Related titles

  • In:Clinical Cancer Research17:14, s. 4814-48241078-04321557-3265

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