Parametric Images of Myocardial Viability Using a Single 15O-H2O PET/CT Scan

Perfusable tissue index (PTI) is a marker of myocardial viability and requires acquisition of transmission, 15O-CO, and 15O-H2O scans. The aim of this study was to generate parametric PTI images from a 15O-H2O PET/CT scan without an additional 15O-CO scan.Methods:Data from 20 patients undergoing both 15O-H2O and 15O-CO scans were used, assessing correlation between PTI based on 15O-CO (PTICO) and on fitted blood volume fractions (PTIVb). In addition, parametric PTIVb images of 10 patients undergoing 15O-H2O PET/CT scans were generated using basis-function methods and compared with PTIVb obtained using nonlinear regression. Simulations were performed to study the effects of noise on PTIVb.Results:Correlation between PTICO and PTIVb was high (r2 = 0.73). Parametric PTIVb correlated well with PTIVb obtained using nonlinear regression (r2 = 0.91). Simulations showed low sensitivity to noise (coefficient of variation < 10% at 20% noise).Conclusion:Parametric PTI images can be generated from a single 15O-H2O PET/CT scan.

de Haan, Stefan (author)
Knaapen, Paul (author)
Allaart, Cornelis P (author)
Lammertsma, Adriaan A (author)
Lubberink, MarkDepartment of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands(Swepub:uu)marklubb (author)
Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands (creator_code:org_t)

In:Journal of Nuclear Medicine: Society of Nuclear Medicine52:5, s. 745-7490161-55051535-56672159-662X

By the author/editor: Harms, Hendrik J; de Haan, Stefan; Knaapen, Paul; Allaart, Corneli ...; Lammertsma, Adri ...; Lubberink, Mark

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Radiology Nuclea ...

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