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Long-term follow-up...
Long-term follow-up of a large series of patients with type 1 gastric carcinoid tumors : Data from a multicenter study
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- Thomas, Dimitrios (author)
- Uppsala universitet,Onkologisk endokrinologi
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- Tsolakis, Apostolos V (author)
- Uppsala universitet,Onkologisk endokrinologi,Kjell Öberg
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Grozinsky-Glasberg, Simona (author)
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Fraenkel, Merav (author)
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Alexandraki, Krystallenia (author)
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Sougioultzis, Stavros (author)
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Gross, David J. (author)
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Kaltsas, Gregory (author)
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(creator_code:org_t)
- 2013
- 2013
- English.
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In: European Journal of Endocrinology. - 0804-4643 .- 1479-683X. ; 168:2, s. 185-193
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- OBJECTIVE:To study the clinical presentation, diagnostic approach, response to treatment and the presence of other pathologies in patients with gastric carcinoid type-1 tumors (GC-1).DESIGN AND METHODS:Retrospective analysis of 111 patients from 4 institutions and a mean follow-up of 76 months.RESULTS:The main indications for gastroscopy were upper gastrointestinal tract symptoms. The mean number of lesions, maximum tumoral diameter and percentage of cells expressing Κi-67 labeling index were 3.6±3.8, 8±12.1mm and 1.9±2.4%, respectively. Serum gastrin and chromogranin A (CgA) levels were elevated in 100/101 and 85/90 patients, respectively. Conventional imaging studies demonstrated pathology in 9/111 patients. Scintigraphy with radiolabelled octreotide was positive in 6/60 without revealing any additional lesions. From the 59 patients who had been followed-up without any intervention 5 developed tumor progression. Thirty-two patients were treated with long acting somatostatin analogues (SSAs), leading to a significant reduction of gastrin and CgA levels, number of visible tumors and CgA immune reactive tumor cells in 28, 19, 27, and 23 treated patients respectively. Antrectomy and/or gastrectomy was initially performed in 20 patients and a complete response was achieved in 13 patients. The most common co-morbidities were vitamin B12 deficiency, thyroiditis and parathyroid adenomas.CONCLUSIONS:Most GCs-1 are grade 1 (82.72%) tumors presenting with stage I (73.87%) disease with no mortality after prolonged follow-up. Ocreoscan did not provide further information compared to conventional imaging techniques. Treatment with SSAs proved to be effective for the duration of administration.
Keyword
- gastric carcinoids type-1
- Oncology
- Onkologi
- Endokrinologi och Diabetologi
- Endocrinology and Diabetology
Publication and Content Type
- ref (subject category)
- art (subject category)
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