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  • Araç, Demet (author)

Dissecting signaling and functions of adhesion G protein-coupled receptors

  • Article/chapterEnglish2012

Publisher, publication year, extent ...

  • 2012-12-07
  • Wiley,2012
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-190095
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-190095URI
  • https://doi.org/10.1111/j.1749-6632.2012.06820.xDOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • G protein-coupled receptors (GPCRs) comprise an expanded superfamily of receptors in the human genome. Adhesion class G protein-coupled receptors (adhesion-GPCRs) form the second largest class of GPCRs. Despite the abundance, size, molecular structure, and functions in facilitating cell and matrix contacts in a variety of organ systems, adhesion-GPCRs are by far the most poorly understood GPCR class. Adhesion-GPCRs possess a unique molecular structure, with extended N-termini containing various adhesion domains. In addition, many adhesion-GPCRs are autoproteolytically cleaved into an N-terminal fragment (NTF, NT, α-subunit) and C-terminal fragment (CTF, CT, β-subunit) at a conserved GPCR autoproteolysis-inducing (GAIN) domain that contains a GPCR proteolysis site (GPS). These two features distinguish adhesion-GPCRs from other GPCR classes. Though active research on adhesion-GPCRs in diverse areas, such as immunity, neuroscience, and development and tumor biology has been intensified in the recent years, the general biological and pharmacological properties of adhesion-GPCRs are not well known, and they have not yet been used for biomedical purposes. The "6th International Adhesion-GPCR Workshop," held at the Institute of Physiology of the University of Würzburg on September 6-8, 2012, assembled a majority of the investigators currently actively pursuing research on adhesion-GPCRs, including scientists from laboratories in Europe, the United States, and Asia. The meeting featured the nascent mechanistic understanding of the molecular events driving the signal transduction of adhesion-GPCRs, novel models to evaluate their functions, and evidence for their involvement in human disease.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Aust, Gabriela (author)
  • Calebiro, Davide (author)
  • Engel, Felix B (author)
  • Formstone, Caroline (author)
  • Goffinet, André (author)
  • Hamann, Jörg (author)
  • Kittel, Robert J (author)
  • Liebscher, Ines (author)
  • Lin, Hsi-Hsien (author)
  • Monk, Kelly R (author)
  • Petrenko, Alexander (author)
  • Piao, Xianhua (author)
  • Prömel, Simone (author)
  • Schiöth, Helgi B.Uppsala universitet,Funktionell farmakologi(Swepub:uu)helgschi (author)
  • Schwartz, Thue W (author)
  • Stacey, Martin (author)
  • Ushkaryov, Yuri A (author)
  • Wobus, Manja (author)
  • Wolfrum, Uwe (author)
  • Xu, Lei (author)
  • Langenhan, Tobias (author)
  • Uppsala universitetFunktionell farmakologi (creator_code:org_t)

Related titles

  • In:Annals of the New York Academy of Sciences: Wiley1276:1, s. 1-250077-89231749-6632

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