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Dissecting signalin...
Dissecting signaling and functions of adhesion G protein-coupled receptors
- Article/chapterEnglish2012
Publisher, publication year, extent ...
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2012-12-07
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Wiley,2012
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-190095
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-190095URI
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https://doi.org/10.1111/j.1749-6632.2012.06820.xDOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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G protein-coupled receptors (GPCRs) comprise an expanded superfamily of receptors in the human genome. Adhesion class G protein-coupled receptors (adhesion-GPCRs) form the second largest class of GPCRs. Despite the abundance, size, molecular structure, and functions in facilitating cell and matrix contacts in a variety of organ systems, adhesion-GPCRs are by far the most poorly understood GPCR class. Adhesion-GPCRs possess a unique molecular structure, with extended N-termini containing various adhesion domains. In addition, many adhesion-GPCRs are autoproteolytically cleaved into an N-terminal fragment (NTF, NT, α-subunit) and C-terminal fragment (CTF, CT, β-subunit) at a conserved GPCR autoproteolysis-inducing (GAIN) domain that contains a GPCR proteolysis site (GPS). These two features distinguish adhesion-GPCRs from other GPCR classes. Though active research on adhesion-GPCRs in diverse areas, such as immunity, neuroscience, and development and tumor biology has been intensified in the recent years, the general biological and pharmacological properties of adhesion-GPCRs are not well known, and they have not yet been used for biomedical purposes. The "6th International Adhesion-GPCR Workshop," held at the Institute of Physiology of the University of Würzburg on September 6-8, 2012, assembled a majority of the investigators currently actively pursuing research on adhesion-GPCRs, including scientists from laboratories in Europe, the United States, and Asia. The meeting featured the nascent mechanistic understanding of the molecular events driving the signal transduction of adhesion-GPCRs, novel models to evaluate their functions, and evidence for their involvement in human disease.
Added entries (persons, corporate bodies, meetings, titles ...)
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Aust, Gabriela
(author)
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Calebiro, Davide
(author)
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Engel, Felix B
(author)
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Formstone, Caroline
(author)
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Goffinet, André
(author)
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Hamann, Jörg
(author)
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Kittel, Robert J
(author)
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Liebscher, Ines
(author)
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Lin, Hsi-Hsien
(author)
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Monk, Kelly R
(author)
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Petrenko, Alexander
(author)
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Piao, Xianhua
(author)
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Prömel, Simone
(author)
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Schiöth, Helgi B.Uppsala universitet,Funktionell farmakologi(Swepub:uu)helgschi
(author)
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Schwartz, Thue W
(author)
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Stacey, Martin
(author)
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Ushkaryov, Yuri A
(author)
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Wobus, Manja
(author)
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Wolfrum, Uwe
(author)
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Xu, Lei
(author)
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Langenhan, Tobias
(author)
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Uppsala universitetFunktionell farmakologi
(creator_code:org_t)
Related titles
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In:Annals of the New York Academy of Sciences: Wiley1276:1, s. 1-250077-89231749-6632
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Araç, Demet
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Aust, Gabriela
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Calebiro, Davide
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Engel, Felix B
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Formstone, Carol ...
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Goffinet, André
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Hamann, Jörg
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Kittel, Robert J
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Liebscher, Ines
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Lin, Hsi-Hsien
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Monk, Kelly R
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Petrenko, Alexan ...
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Piao, Xianhua
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Prömel, Simone
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Schiöth, Helgi B ...
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Schwartz, Thue W
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Stacey, Martin
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Ushkaryov, Yuri ...
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Wobus, Manja
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Wolfrum, Uwe
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Xu, Lei
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Langenhan, Tobia ...
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Uppsala University