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Circulating levels ...
Circulating levels of persistent organic pollutants are related to retrospective assessment of life-time weight change
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- Lind, Monica P. (author)
- Uppsala universitet,Arbets- och miljömedicin,Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden
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- Lee, D. -H (author)
- Department of Preventative Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea
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- Jacobs, D. R. (author)
- Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis MN, USA; Department of Nutrition, School of Medicine, University of Oslo, Oslo, Norway
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- Salihovic, Samira, 1985- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Center,Department of Preventive Medicine, Mount Sinai School of Medicine, New York NY, USA
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- van Bavel, Bert, 1963- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,MTM Research Center
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Wolff, M. S. (author)
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi,Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- English.
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In: Chemosphere. - : Elsevier BV. - 0045-6535 .- 1879-1298. ; 90:3, s. 998-1004
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Background: Persistent organic pollutants (POPs) have been suggested to be linked to obesity. We have previously shown that less-chlorinated PCBs were positively related to fat mass, while highly-chlorinated PCBs were inversely related to obesity.Objective: The aim of the present evaluation is to investigate the relationship between retrospective assessed life-time change in body weight (20-70. years) with circulating POP levels measured at age 70. years.Methods: 1016 subjects aged 70. years were investigated in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUSs) study. 16 PCBs and 3 OC pesticides were analyzed using HRGC/HRMS. Current body weight was measured and participants self-reported their weight at age 20.Results: The average estimated weight change over 50. years was 14.4. kg. Both the sum of OC pesticide concentrations (4.3. kg more weight gain in quintile 5 vs. quintile 1, p< 0.0001) and the sum of the less-chlorinated PCBs were positively related to the estimated weight change (3.7. kg more weight gain in quintile 2 vs. quintile 1, non-linear relationship p=0.0015). In contrast, the sum of concentrations of highly-chlorinated PCBs were inversely related to estimated weight change (8.4. kg less weight gain in quintile 5 vs. quintile 1, p< 0.0001).Conclusion: High levels of OC pesticides and the less-chlorinated PCBs at age 70 were associated with a pronounced estimated weight change over the previous 50. years. However, the opposite was seen for highly-chlorinated PCBs. Differences in mode of action, toxicokinetics, non-linear relationships and reverse causation might explain these discrepancies.
Subject headings
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- Elderly
- Fat mass
- Life time weight change
- Obesity
- Persistent organic pollutants
- Life-times
- Persistent organic pollutant (POP)
- Anthropometry
- Nutrition
- Pesticides
- Polychlorinated biphenyls
- Organic pollutants
- benzene derivative
- organic compound
- organochlorine pesticide
- polybrominated diphenyl ether
- polychlorinated biphenyl
- body mass
- chlorinated hydrocarbon
- concentration (composition)
- elderly population
- health impact
- organic pollutant
- PCB
- persistence
- pesticide
- pollution exposure
- toxicology
- age
- aged
- article
- female
- human
- major clinical study
- male
- mass spectrometry
- organic pollution
- self report
- toxicokinetics
- weight change
- weight gain
- Sweden
- Uppsala [Sweden]
- Enviromental Science
Publication and Content Type
- ref (subject category)
- art (subject category)
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