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Psoriasis susceptib...
Psoriasis susceptibility locus in chromosome region 3q21 identified in patients from southwest Sweden
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- Enlund, Fredrik, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics
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- Samuelsson, Lena, 1962 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics
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- Enerbäck, Charlotta, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för dermatologi och venereologi,Institute of Selected Clinical Sciences, Department of Dermatology and Venereology
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- Inerot, Annica, 1949 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för dermatologi och venereologi,Institute of Selected Clinical Sciences, Department of Dermatology and Venereology
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- Wahlström, Jan, 1939 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics
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- Yhr, Maria, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa,Institute for the Health of Women and Children
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- Torinsson Naluai, Åsa, 1968 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa,Institute for the Health of Women and Children
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Riley, J. (author)
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- Swanbeck, Gunnar, 1934 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för särskilda specialiteter, Avdelningen för dermatologi och venereologi,Institute of Selected Clinical Sciences, Department of Dermatology and Venereology
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- Martinsson, Tommy, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics
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(creator_code:org_t)
- 1999
- 1999
- English.
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In: Eur J Hum Genet. ; 7:7, s. 783-90
- Related links:
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https://gup.ub.gu.se...
Abstract
Subject headings
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- We have performed a pair-wise linkage study in the search for psoriasis susceptibility regions. A preliminary scan was performed on 20 families. In this set we obtained indications of linkage on chromosome 3q21. This region was further investigated using material from a total of 104 families (set 1B) resulting in a non-parametric linkage (NPL) of 1.77. The material was stratified in families whose parental origin is in southwest Sweden (set 1C). A maximum NPL value of 2.77 was obtained in this group. A transmission disequilibrium test (TDT) was performed on the stratified material (set 1C) and a significant P value of 0.005 was obtained, at marker D3S1269. The locus was confirmed with TDT in replicate material consisting of 148 families in which a single member was affected (P value 0.0007) at marker D3S1551. Thus, we have observed a significant P value using TDT in the vicinity of markers D3S1269/D3S1551, suggesting a novel psoriasis susceptibility region.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences (hsv//eng)
Keyword
- Chromosome Mapping
- Chromosomes
- Human
- Pair 3/*genetics
- Family
- Female
- Genetic Predisposition to Disease/*genetics
- Humans
- Linkage (Genetics)
- Linkage Disequilibrium/*genetics
- Male
- Psoriasis/*genetics
- Research Support
- Non-U.S. Gov't
- Sweden
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Enlund, Fredrik, ...
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Samuelsson, Lena ...
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Enerbäck, Charlo ...
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Inerot, Annica, ...
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Wahlström, Jan, ...
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Yhr, Maria, 1968
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Torinsson Naluai ...
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Riley, J.
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Swanbeck, Gunnar ...
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Martinsson, Tomm ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Other Medical an ...
- Articles in the publication
- Eur J Hum Genet
- By the university
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University of Gothenburg