Meta-Analysis Investigating Associations Between Healthy Diet and Fasting Glucose and Insulin Levels and Modification by Loci Associated With Glucose Homeostasis in Data From 15 Cohorts

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Nettleton, Jennifer A. (author)

Meta-Analysis Investigating Associations Between Healthy Diet and Fasting Glucose and Insulin Levels and Modification by Loci Associated With Glucose Homeostasis in Data From 15 Cohorts

Article/chapterEnglish2013

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2012-12-19
Oxford University Press (OUP),2013
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LIBRIS-ID:oai:DiVA.org:uu-194828
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-194828URI
https://doi.org/10.1093/aje/kws297DOI
https://lup.lub.lu.se/record/3470537URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:125973634URI
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-66407URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:for swepub-publicationtype

Notes

Whether loci that influence fasting glucose (FG) and fasting insulin (FI) levels, as identified by genome-wide association studies, modify associations of diet with FG or FI is unknown. We utilized data from 15 US and European cohort studies comprising 51,289 persons without diabetes to test whether genotype and diet interact to influence FG or FI concentration. We constructed a diet score using study-specific quartile rankings for intakes of whole grains, fish, fruits, vegetables, and nuts/seeds (favorable) and red/processed meats, sweets, sugared beverages, and fried potatoes (unfavorable). We used linear regression within studies, followed by inverse-variance-weighted meta-analysis, to quantify 1) associations of diet score with FG and FI levels and 2) interactions of diet score with 16 FG-associated loci and 2 FI-associated loci. Diet score (per unit increase) was inversely associated with FG ( 0.004 mmol/L, 95 confidence interval: 0.005, 0.003) and FI ( 0.008 ln-pmol/L, 95 confidence interval: 0.009, 0.007) levels after adjustment for demographic factors, lifestyle, and body mass index. Genotype variation at the studied loci did not modify these associations. Healthier diets were associated with lower FG and FI concentrations regardless of genotype at previously replicated FG- and FI-associated loci. Studies focusing on genomic regions that do not yield highly statistically significant associations from main-effect genome-wide association studies may be more fruitful in identifying diet-gene interactions.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
diabetes
dietary pattern
gene-environment interaction
glucose
insulin
diabetes
dietary pattern
gene-environment interaction
glucose
insulin

Added entries (persons, corporate bodies, meetings, titles ...)

Hivert, Marie-France (author)
Lemaitre, Rozenn N. (author)
McKeown, Nicola M. (author)
Mozaffarian, Dariush (author)
Tanaka, Toshiko (author)
Wojczynski, Mary K. (author)
Hruby, Adela (author)
Djousse, Luc (author)
Ngwa, Julius S. (author)
Follis, Jack L. (author)
Dimitriou, Maria (author)
Ganna, AndreaKarolinska Institutet (author)
Houston, Denise K. (author)
Kanoni, Stavroula (author)
Mikkila, Vera (author)
Manichaikul, Ani (author)
Ntalla, Ioanna (author)
Renström, FridaUmeå universitet,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Medicin(Swepub:umu)frre0001 (author)
Sonestedt, EmilyLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Nutritionsepidemiologi,Diabetes - Cardiovascular Disease,Lund University Research Groups,Nutrition Epidemiology(Swepub:lu)medf-eso (author)
van Rooij, Frank J. A. (author)
Bandinelli, Stefania (author)
de Koning, Lawrence (author)
Ericson, UlrikaLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Nutritionsepidemiologi,Diabetes - Cardiovascular Disease,Lund University Research Groups,Nutrition Epidemiology(Swepub:lu)medf-upe (author)
Hassanali, Neelam (author)
Kiefte-de Jong, Jessica C. (author)
Lohman, Kurt K. (author)
Raitakari, Olli (author)
Papoutsakis, Constantina (author)
Sjögren, PerUppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)persj732 (author)
Stirrups, Kathleen (author)
Ax, ErikaUppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)eriax774 (author)
Deloukas, Panos (author)
Groves, Christopher J. (author)
Franks, PaulUmeå universitet,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Medicin(Swepub:umu)pafr0003 (author)
Johansson, IngegerdUmeå universitet,Kariologi(Swepub:umu)injo0003 (author)
Liu, Yongmei (author)
McCarthy, Mark I. (author)
North, Kari (author)
Viikari, Jorma (author)
Zillikens, M. Carola (author)
Dupuis, Josee (author)
Hofman, Albert (author)
Kolovou, Genovefa (author)
Mukamal, Kenneth (author)
Prokopenko, Inga (author)
Rolandsson, OlovUmeå universitet,Allmänmedicin(Swepub:umu)olro0005 (author)
Seppala, Ilkka (author)
Cupples, L. Adrienne (author)
Hu, Frank B. (author)
Kahonen, Mika (author)
Uitterlinden, Andre G. (author)
Borecki, Ingrid B. (author)
Ferrucci, Luigi (author)
Jacobs, David R., Jr. (author)
Kritchevsky, Stephen B. (author)
Orho-Melander, MarjuLund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)endo-mor (author)
Pankow, James S. (author)
Lehtimaki, Terho (author)
Witteman, Jacqueline C. M. (author)
Ingelsson, Erik (author)
Siscovick, David S. (author)
Dedoussis, George (author)
Meigs, James B. (author)
Franks, Paul W. (author)
Karolinska InstitutetGenetisk och molekylär epidemiologi (creator_code:org_t)

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In:American Journal of Epidemiology: Oxford University Press (OUP)177:2, s. 103-1150002-92621476-6256

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By the author/editor: Nettleton, Jenni ...; Hivert, Marie-Fr ...; Lemaitre, Rozenn ...; McKeown, Nicola ...; Mozaffarian, Dar ...; Tanaka, Toshiko; show more...; Wojczynski, Mary ...; Hruby, Adela; Djousse, Luc; Ngwa, Julius S.; Follis, Jack L.; Dimitriou, Maria; Ganna, Andrea; Houston, Denise ...; Kanoni, Stavroul ...; Mikkila, Vera; Manichaikul, Ani; Ntalla, Ioanna; Renström, Frida; Sonestedt, Emily; van Rooij, Frank ...; Bandinelli, Stef ...; de Koning, Lawre ...; Ericson, Ulrika; Hassanali, Neela ...; Kiefte-de Jong, ...; Lohman, Kurt K.; Raitakari, Olli; Papoutsakis, Con ...; Sjögren, Per; Stirrups, Kathle ...; Ax, Erika; Deloukas, Panos; Groves, Christop ...; Franks, Paul; Johansson, Ingeg ...; Liu, Yongmei; McCarthy, Mark I ...; North, Kari; Viikari, Jorma; Zillikens, M. Ca ...; Dupuis, Josee; Hofman, Albert; Kolovou, Genovef ...; Mukamal, Kenneth; Prokopenko, Inga; Rolandsson, Olov; Seppala, Ilkka; Cupples, L. Adri ...; Hu, Frank B.; Kahonen, Mika; Uitterlinden, An ...; Borecki, Ingrid ...; Ferrucci, Luigi; Jacobs, David R. ...; Kritchevsky, Ste ...; Orho-Melander, M ...; Pankow, James S.; Lehtimaki, Terho; Witteman, Jacque ...; Ingelsson, Erik; Siscovick, David ...; Dedoussis, Georg ...; Meigs, James B.; Franks, Paul W.; show less...

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