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High expression of ...
High expression of microRNA-200c predicts poor clinical outcome in diffuse large B-cell lymphoma
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- Berglund, Mattias (author)
- Uppsala universitet,Enheten för onkologi
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- Hedström, Gustaf (author)
- Uppsala universitet,Enheten för onkologi
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- Amini, Rose-Marie (author)
- Uppsala universitet,Molekylär och morfologisk patologi
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- Enblad, Gunilla (author)
- Uppsala universitet,Enheten för onkologi
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- Thunberg, Ulf (author)
- Uppsala universitet,Enheten för onkologi
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(creator_code:org_t)
- 2012-12-10
- 2013
- English.
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In: Oncology Reports. - : Spandidos Publications. - 1021-335X .- 1791-2431. ; 29:2, s. 720-724
- Related links:
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https://www.spandido...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Subject headings
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- Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of B-cell lymphomas. A new and important tool for understanding the biology and clinical course of DLBCL is microRNA expression. This study presents microRNA-200c expression data from 61 DLBCL patients treated with CHOP or R-CHOP. Patients with high microRNA-200c expression had a median survival of 20.3 months and a significantly shorter overall survival (P=0.019) compared to patients with low microRNA-200c expression, who had a median survival of 35.8 months. We also found that patients treated with R-CHOP only and displaying high microRNA-200c expression had a significantly shorter overall survival compared to patients with low microRNA-200c expression, where all patients were still alive at the time of the last follow-up (P=0.0036). Lastly, we found that patients with high microRNA-200c expression had a significantly shorter time from initial diagnosis to the first relapse compared to patients with low microRNA-200c expression (P=0.0001). To our knowledge, this is the first study showing that the expression of microRNA-200c affects the clinical outcome of DLBCL patients, and that microRNA-200c is involved in the biology of DLBCL development, although larger studies are necessary to confirm this. Further investigations may also help to elucidate the biological role of microRNA-200c in DLBCL.
Keyword
- Diffuse large B-cell lymphoma
- microRNA-200c
- Prognosis
Publication and Content Type
- ref (subject category)
- art (subject category)
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