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Synthesis of antima...
Synthesis of antimalarial compounds fosmidomycin and FR900098 through N- or P-alkylation reactions
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- Suresh, Surisetti (author)
- Uppsala universitet,Avdelningen för organisk farmaceutisk kemi
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- Shyamraj, Dharavath (author)
- Uppsala universitet,Avdelningen för organisk farmaceutisk kemi
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- Larhed, Mats (author)
- Uppsala universitet,Avdelningen för organisk farmaceutisk kemi
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(creator_code:org_t)
- Elsevier BV, 2013
- 2013
- English.
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In: Tetrahedron. - : Elsevier BV. - 0040-4020 .- 1464-5416. ; 69:3, s. 1183-1188
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Two straightforward and convenient routes for the synthesis of the antimalarial agents FR900098 and fosmidomycin are described. In the key steps N- or P-alkylation reactions are used. The best overall yields of FR900098 and fosmidomycin in 15 mmol scale are 83% and 68%, respectively. These routes utilize readily available materials and avoid harsh conditions.
Keyword
- Fosmidomycin
- FR900098
- N-alkylation
- P-alkylation
- 3 (n acetyl n hydroxyamino)propylphosphonic acid
- antimalarial agent
- nitrogen
- phosphorus
- unclassified drug
- alkylation
- article
- drug synthesis
- priority journal
Publication and Content Type
- ref (subject category)
- art (subject category)
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