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Mesoporous silica p...
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Kupferschmidt, NataliaUppsala universitet,Nanoteknologi och funktionella material
(författare)
Mesoporous silica particles potentiate antigen specific T cell responses
- Artikel/kapitelEngelska2014
Förlag, utgivningsår, omfång ...
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Future Medicine Ltd,2014
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-195901
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-195901URI
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https://doi.org/10.2217/nnm.13.170DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Aim: To study the adjuvant effect of mesoporous silica particles and their capability of modifying an already existing allergic Th2-like immune response. Materials & methods: The adjuvant effect of Santa Barbara Amorphous-15 (SBA-15) mesoporous silica particles was studied in an antigen-specific ovalbumin (OVA) system in vitro and in vivo. The capacity of the OVA-loaded SBA-15 particles (SBA-15-OVA) to modify an existing immune response was assessed in a murine allergy model. Results: SBA-15-OVA induced significantly stronger OVA-specific splenocyte proliferation compared with OVA alone. Significantly higher IFN-γ production was observed in ex vivo OVA-stimulated splenocytes from SBA-15-OVA-immunized mice compared with mice injected with only SBA-15 or OVA. Treatment of OVA-sensitized mice with SBA-15-OVA modified the immune response with significantly lower serum levels of OVA-specific IgE and higher IgG levels compared with the alum-OVA-treated group. Conclusion: The results are promising for the continued development of mesoporous silica materials for therapeutic applications. Original submitted 18 January 2013; Revised submitted 30 August 2013
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Rahman Qazi, KhaledaDept of Medicine Solna, Translational Immunology Unit, KI, Stockholm, Sweden
(författare)
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Kemi, CeciliaExperimental Asthma and Allergy Research, Centre for Allergy Research, The Institute of Environmental Medicine, KI, Stockholm, Sweden
(författare)
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Vallhov, HelenDept of Medicine Solna, Translational Immunology Unit, KI, Stockholm, Sweden
(författare)
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Garcia-Bennett, Alfonso EStockholm Univ, Dept Mat & Environm Chem, Stockholm, Sweden(Swepub:uu)alfga768
(författare)
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Gabrielsson, SusanneDept of Medicine Solna, Translational Immunology Unit, KI, Stockholm, Sweden
(författare)
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Scheynius, AnnikaDept of Medicine Solna, Translational Immunology Unit, KI, Stockholm, Sweden
(författare)
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Uppsala universitetNanoteknologi och funktionella material
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Nanomedicine: Future Medicine Ltd9:12, s. 1835-18461743-58891748-6963
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