Mesoporous silica particles potentiate antigen specific T cell responses

Kupferschmidt, NataliaUppsala universitet,Nanoteknologi och funktionella material (författare)

Aim: To study the adjuvant effect of mesoporous silica particles and their capability of modifying an already existing allergic Th2-like immune response. Materials & methods: The adjuvant effect of Santa Barbara Amorphous-15 (SBA-15) mesoporous silica particles was studied in an antigen-specific ovalbumin (OVA) system in vitro and in vivo. The capacity of the OVA-loaded SBA-15 particles (SBA-15-OVA) to modify an existing immune response was assessed in a murine allergy model. Results: SBA-15-OVA induced significantly stronger OVA-specific splenocyte proliferation compared with OVA alone. Significantly higher IFN-γ production was observed in ex vivo OVA-stimulated splenocytes from SBA-15-OVA-immunized mice compared with mice injected with only SBA-15 or OVA. Treatment of OVA-sensitized mice with SBA-15-OVA modified the immune response with significantly lower serum levels of OVA-specific IgE and higher IgG levels compared with the alum-OVA-treated group. Conclusion: The results are promising for the continued development of mesoporous silica materials for therapeutic applications. Original submitted 18 January 2013; Revised submitted 30 August 2013

Rahman Qazi, KhaledaDept of Medicine Solna, Translational Immunology Unit, KI, Stockholm, Sweden (författare)
Kemi, CeciliaExperimental Asthma and Allergy Research, Centre for Allergy Research, The Institute of Environmental Medicine, KI, Stockholm, Sweden (författare)
Vallhov, HelenDept of Medicine Solna, Translational Immunology Unit, KI, Stockholm, Sweden (författare)
Garcia-Bennett, Alfonso EStockholm Univ, Dept Mat & Environm Chem, Stockholm, Sweden(Swepub:uu)alfga768 (författare)
Gabrielsson, SusanneDept of Medicine Solna, Translational Immunology Unit, KI, Stockholm, Sweden (författare)
Scheynius, AnnikaDept of Medicine Solna, Translational Immunology Unit, KI, Stockholm, Sweden (författare)
Uppsala universitetNanoteknologi och funktionella material (creator_code:org_t)

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