Search: (WFRF:(Pirastu Mario)) pers:(Martin Nicholas G.) pers:(Montgomery Grant W.) >
Genome-wide associa...
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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2012-12-23
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Springer Science and Business Media LLC,2013
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-196032
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-196032URI
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https://doi.org/10.1038/ng.2500DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SEMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout.
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Albrecht, Eva
(author)
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Teumer, Alexander
(author)
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Vitart, Veronique
(author)
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Krumsiek, Jan
(author)
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Hundertmark, Claudia
(author)
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Pistis, Giorgio
(author)
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Ruggiero, Daniela
(author)
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O'Seaghdha, Conall M.
(author)
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Haller, Toomas
(author)
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Yang, Qiong
(author)
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Tanaka, Toshiko
(author)
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Johnson, Andrew D.
(author)
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Kutalik, Zoltan
(author)
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Smith, Albert V.
(author)
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Shi, Julia
(author)
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Struchalin, Maksim
(author)
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Middelberg, Rita P. S.
(author)
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Brown, Morris J.
(author)
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Gaffo, Angelo L.
(author)
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Pirastu, Nicola
(author)
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Li, Guo
(author)
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Hayward, Caroline
(author)
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Zemunik, Tatijana
(author)
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Huffman, Jennifer
(author)
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Yengo, Loic
(author)
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Zhao, Jing Hua
(author)
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Demirkan, Ayse
(author)
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Feitosa, Mary F.
(author)
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Liu, Xuan
(author)
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Malerba, Giovanni
(author)
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Lopez, Lorna M.
(author)
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van der Harst, Pim
(author)
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Li, Xinzhong
(author)
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Kleber, Marcus E.
(author)
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Hicks, Andrew A.
(author)
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Nolte, Ilja M.
(author)
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Johansson, ÅsaUppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för immunologi, genetik och patologi(Swepub:uu)asjoh108
(author)
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Murgia, Federico
(author)
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Wild, Sarah H.
(author)
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Bakker, Stephan J. L.
(author)
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Peden, John F.
(author)
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Dehghan, Abbas
(author)
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Steri, Maristella
(author)
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Tenesa, Albert
(author)
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Lagou, Vasiliki
(author)
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Salo, Perttu
(author)
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Mangino, Massimo
(author)
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Rose, Lynda M.
(author)
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Lehtimaki, Terho
(author)
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Woodward, Owen M.
(author)
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Okada, Yukinori
(author)
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Tin, Adrienne
(author)
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Mueller, Christian
(author)
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Oldmeadow, Christopher
(author)
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Putku, Margus
(author)
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Czamara, Darina
(author)
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Kraft, Peter
(author)
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Frogheri, Laura
(author)
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Thun, Gian Andri
(author)
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Grotevendt, Anne
(author)
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Gislason, Gauti Kjartan
(author)
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Harris, Tamara B.
(author)
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Launer, Lenore J.
(author)
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McArdle, Patrick
(author)
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Shuldiner, Alan R.
(author)
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Boerwinkle, Eric
(author)
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Coresh, Josef
(author)
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Schmidt, Helena
(author)
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Schallert, Michael
(author)
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Martin, Nicholas G.
(author)
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Montgomery, Grant W.
(author)
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Kubo, Michiaki
(author)
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Nakamura, Yusuke
(author)
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Tanaka, Toshihiro
(author)
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Munroe, Patricia B.
(author)
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Samani, Nilesh J.
(author)
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Jacobs, David R., Jr.
(author)
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Liu, Kiang
(author)
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D'Adamo, Pio
(author)
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Ulivi, Sheila
(author)
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Rotter, Jerome I.
(author)
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Psaty, Bruce M.
(author)
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Vollenweider, Peter
(author)
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Waeber, Gerard
(author)
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Campbell, Susan
(author)
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Devuyst, Olivier
(author)
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Navarro, Pau
(author)
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Kolcic, Ivana
(author)
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Hastie, Nicholas
(author)
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Balkau, Beverley
(author)
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Froguel, Philippe
(author)
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Esko, Tonu
(author)
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Salumets, Andres
(author)
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Khaw, Kay Tee
(author)
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Langenberg, Claudia
(author)
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Wareham, Nicholas J.
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Isaacs, Aaron
(author)
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Kraja, Aldi
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Zhang, Qunyuan
(author)
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Wild, Philipp S.
(author)
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Scott, Rodney J.
(author)
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Holliday, Elizabeth G.
(author)
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Org, Elin
(author)
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Viigimaa, Margus
(author)
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Bandinelli, Stefania
(author)
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Metter, Jeffrey E.
(author)
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Lupo, Antonio
(author)
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Trabetti, Elisabetta
(author)
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Sorice, Rossella
(author)
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Doering, Angela
(author)
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Lattka, Eva
(author)
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Strauch, Konstantin
(author)
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Theis, Fabian
(author)
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Waldenberger, Melanie
(author)
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Wichmann, H-Erich
(author)
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Davies, Gail
(author)
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Gow, Alan J.
(author)
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Bruinenberg, Marcel
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Stolk, Ronald P.
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Kooner, Jaspal S.
(author)
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Zhang, Weihua
(author)
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Winkelmann, Bernhard R.
(author)
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Boehm, Bernhard O.
(author)
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Lucae, Susanne
(author)
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Penninx, Brenda W.
(author)
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Smit, Johannes H.
(author)
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Curhan, Gary
(author)
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Mudgal, Poorva
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Plenge, Robert M.
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Portas, Laura
(author)
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Persico, Ivana
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Kirin, Mirna
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Wilson, James F.
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Leach, Irene Mateo
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van Gilst, Wiek H.
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Goel, Anuj
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Ongen, Halit
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Hofman, Albert
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Rivadeneira, Fernando
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Uitterlinden, Andre G.
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Imboden, Medea
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von Eckardstein, Arnold
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Cucca, Francesco
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Nagaraja, Ramaiah
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Piras, Maria Grazia
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Nauck, Matthias
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Schurmann, Claudia
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Budde, Kathrin
(author)
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Ernst, Florian
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Farrington, Susan M.
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Theodoratou, Evropi
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Prokopenko, Inga
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Stumvoll, Michael
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Jula, Antti
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Perola, Markus
(author)
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Salomaa, Veikko
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Shin, So-Youn
(author)
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Spector, Tim D.
(author)
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Sala, Cinzia
(author)
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Ridker, Paul M.
(author)
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Kaehoenen, Mika
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Viikari, Jorma
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Hengstenberg, Christian
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Nelson, Christopher P.
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Meschia, James F.
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Nalls, Michael A.
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Sharma, Pankaj
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Singleton, Andrew B.
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Kamatani, Naoyuki
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Zeller, Tanja
(author)
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Burnier, Michel
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Attia, John
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Laan, Maris
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Klopp, Norman
(author)
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Hillege, Hans L.
(author)
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Kloiber, Stefan
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Choi, Hyon
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Pirastu, Mario
(author)
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Tore, Silvia
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Probst-Hensch, Nicole M.
(author)
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Voelzke, Henry
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Gudnason, Vilmundur
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Parsa, Afshin
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Schmidt, Reinhold
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Whitfield, John B.
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Fornage, Myriam
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Gasparini, Paolo
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Siscovick, David S.
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Polasek, Ozren
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Campbell, Harry
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Rudan, Igor
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Bouatia-Naji, Nabila
(author)
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Metspalu, Andres
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Loos, Ruth J. F.
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van Duijn, Cornelia M.
(author)
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Borecki, Ingrid B.
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Ferrucci, Luigi
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Gambaro, Giovanni
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Deary, Ian J.
(author)
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Wolffenbuttel, Bruce H. R.
(author)
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Chambers, John C.
(author)
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Maerz, Winfried
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Pramstaller, Peter P.
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Snieder, Harold
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Gyllensten, UlfUppsala universitet,Genomik(Swepub:uu)ulfgyll
(author)
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Wright, Alan F.
(author)
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Navis, Gerjan
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Watkins, Hugh
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Witteman, Jacqueline C. M.
(author)
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Sanna, Serena
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Schipf, Sabine
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Dunlop, Malcolm G.
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Toenjes, Anke
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Ripatti, Samuli
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Soranzo, Nicole
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Toniolo, Daniela
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Chasman, Daniel I.
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Raitakari, Olli
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Kao, W. H. Linda
(author)
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Ciullo, Marina
(author)
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Fox, Caroline S.
(author)
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Caulfield, Mark
(author)
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Bochud, Murielle
(author)
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Gieger, Christian
(author)
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Uppsala universitetUppsala kliniska forskningscentrum (UCR)
(creator_code:org_t)
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In:Nature Genetics: Springer Science and Business Media LLC45:2, s. 145-1541061-40361546-1718
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