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Cerebral blood flow...
Cerebral blood flow changes after treatment of social phobia with the neurokinin-1 antagonist GR205171, citalopram, or placebo.
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- Furmark, Tomas (författare)
- Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden
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- Appel, Lieuwe (författare)
- Uppsala Imanet AB, Uppsala, Sweden
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- Michelgård, Asa (författare)
- Department of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden
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- Wahlstedt, Kurt (författare)
- Quintiles AB Phase I Services, Uppsala, Sweden
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- Åhs, Fredrik (författare)
- Uppsala universitet,Institutionen för psykologi,Department of Psychology, Uppsala University, Uppsala, Sweden
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- Zancan, Stefano (författare)
- GlaxoSmithKline, Medicine Research Centre, Verona, Italy
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- Jacobsson, Eva (författare)
- Quintiles AB Phase I Services, Uppsala, Sweden
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- Flyckt, Karin (författare)
- Department of Psychology, Uppsala University, Uppsala, Sweden
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- Grohp, Magnus (författare)
- Department of Psychology, Uppsala University, Uppsala, Sweden
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- Bergstrom, Mats (författare)
- GlaxoSmithKline, Medicine Research Centre, Verona, Italy
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- Pich, Emilio Merlo (författare)
- GlaxoSmithKline, Medicine Research Centre, Verona, Italy
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- Nilsson, Lars-Göran (författare)
- Quintiles AB Phase I Services, Uppsala, Sweden
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- Bani, Massimo (författare)
- Uppsala Imanet AB, Uppsala, Sweden; GlaxoSmithKline, Medicine Research Centre, Verona, Italy
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- Långström, Bengt (författare)
- Uppsala Imanet AB, Uppsala, Sweden
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- Fredrikson, Mats (författare)
- Department of Psychology, Uppsala University, Uppsala, Sweden
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(creator_code:org_t)
- Elsevier, 2005
- 2005
- Engelska.
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Ingår i: Biol Psychiatry. - : Elsevier. - 0006-3223 .- 1873-2402. ; 58:2, s. 132-42
- Relaterad länk:
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http://www.ncbi.nlm....
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Evidence is accumulating that pharmacological blockade of the substance P preferring neurokinin-1 (NK1) receptor reduces anxiety. This study compared the effects of an NK1 receptor antagonist, citalopram, and placebo on brain activity and anxiety symptoms in social phobia. METHODS: Thirty-six patients diagnosed with social phobia were treated for 6 weeks with the NK1 antagonist GR205171 (5 mg), citalopram (40 mg), or matching placebo under randomized double-blind conditions. GR205171 was administered for 4 weeks preceded by 2 weeks of placebo. Before and after treatment, regional cerebral blood flow (rCBF) during a stressful public speaking task was assessed using oxygen-15 positron emission tomography. Response rate was determined by the Clinical Global Impression Improvement Scale. RESULTS: Patients improved to a larger extent with the NK1 antagonist (41.7% responders) and citalopram (50% responders), compared with placebo (8.3% responders). Within- and between-group comparisons showed that symptom improvement was paralleled by a significantly reduced rCBF response to public speaking in the rhinal cortex, amygdala, and parahippocampal-hippocampal regions. The rCBF pattern was corroborated in follow-up analyses of responders and subjects showing large state anxiety reduction. CONCLUSIONS: Short-term administration of GR205171 and citalopram alleviated social anxiety. Neurokinin-1 antagonists may act like serotonin reuptake inhibitors by attenuating neural activity in a medial temporal lobe network.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology -- Psychology (hsv//eng)
Nyckelord
- Adult
- Anxiety/*drug therapy/physiopathology
- Cerebrovascular Circulation/*drug effects
- Citalopram/*pharmacology/therapeutic use
- Comparative Study
- Double-Blind Method
- Female
- Humans
- Male
- Phobic Disorders/*drug therapy/physiopathology
- Piperidines/*pharmacology/therapeutic use
- Positron-Emission Tomography
- Receptors; Neurokinin-1/antagonists & inhibitors
- Research Support; Non-U.S. Gov't
- Serotonin Uptake Inhibitors/*pharmacology/therapeutic use
- Temporal Lobe/blood supply/radionuclide imaging
- Tetrazoles/*pharmacology/therapeutic use
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Till lärosätets databas
- Av författaren/redakt...
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Furmark, Tomas
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Appel, Lieuwe
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Michelgård, Asa
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Wahlstedt, Kurt
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Åhs, Fredrik
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Zancan, Stefano
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visa fler...
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Jacobsson, Eva
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Flyckt, Karin
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Grohp, Magnus
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Bergstrom, Mats
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Pich, Emilio Mer ...
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Nilsson, Lars-Gö ...
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Bani, Massimo
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Långström, Bengt
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Fredrikson, Mats
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Psykiatri
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- SAMHÄLLSVETENSKAP
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SAMHÄLLSVETENSKA ...
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och Psykologi
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Biol Psychiatry
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Uppsala universitet
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