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- Jansson, Anna M.,1979-Uppsala universitet,Struktur- och molekylärbiologi,T. Alwyn Jones (author)
Structure of Alphacoronavirus Transmissible Gastroenteritis Virus nsp1 Has Implications for Coronavirus nsp1 Function and Evolution
- Article/chapterEnglish2013
Publisher, publication year, extent ...
- American Society for Microbiology,2013
- printrdacarrier
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- LIBRIS-ID:oai:DiVA.org:uu-196611
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-196611URI
- https://doi.org/10.1128/JVI.03163-12DOI
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- Language:English
- Summary in:English
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- Coronavirus nsp1 has been shown to induce suppression of host gene expression and to interfere with the host immune re- sponse. However, the mechanism is currently unknown. The only available structural information on coronavirus nsp1 is the nuclear magnetic resonance (NMR) structure of the N-terminal domain of nsp1 from severe acute respiratory syndrome corona- virus (SARS-CoV) from the betacoronavirus genus. Here we present the first nsp1 structure from an alphacoronavirus, transmis- sible gastroenteritis virus (TGEV) nsp1. It displays a six-stranded -barrel fold with a long alpha helix on the rim of the barrel, a fold shared with SARS-CoV nsp113–128. Contrary to previous speculation, the TGEV nsp1 structure suggests that coronavirus nsp1s have a common origin, despite the lack of sequence homology. However, comparisons of surface electrostatics, shape, and amino acid conservation between the alpha- and betacoronaviruses lead us to speculate that the mechanism for nsp1-induced suppression of host gene expression might be different in these two genera.
Subject headings and genre
- NATURVETENSKAP Biologi Strukturbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Structural Biology hsv//eng
- Coronavirus
- Alphacoronavirus
- nsp1
- Molecular Biology
- Molekylärbiologi
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- Uppsala universitetStruktur- och molekylärbiologi (creator_code:org_t)
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- In:Journal of Virology: American Society for Microbiology87:5, s. 2949-29550022-538X1098-5514
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