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Short-term prognosi...
Short-term prognosis of contemporary interventional therapy of ST-elevation myocardial infarction : does gender matter?
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Zimmermann, Stefan (författare)
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Ruthrof, Susanne (författare)
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Nowak, Kathrin (författare)
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Alff, Anna (författare)
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Klinghammer, Lutz (författare)
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Schneider, Reinhard (författare)
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Ludwig, Josef (författare)
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Pfahlberg, Annette B (författare)
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Daniel, Werner G (författare)
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- Flachskampf, Frank A (författare)
- Medizinische Klinik 2 (Kardiologie/Angiologie), Universitätsklinikum Erlangen, Erlangen, Germany
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(creator_code:org_t)
- 2009-08-19
- 2009
- Engelska.
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Ingår i: Clinical Research in Cardiology. - : Springer Science and Business Media LLC. - 1861-0684 .- 1861-0692. ; 98:11, s. 709-715
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- BACKGROUND:A higher mortality risk for women with acute ST-elevation myocardial infarction (STEMI) has been a common finding in the past, even after acute percutaneous coronary intervention (PCI). We set out to analyze whether there are gender differences in real-world contemporary treatment and outcomes of STEMI.PATIENTS AND METHODS:A retrospective analysis of all consecutive patients with STEMI and acute coronary angiography with the intention of performing a PCI at our center 6/1999-6/2006 was carried out (n = 566). Data were examined for gender-specific differences regarding patients' characteristics, referral patterns, timing of acute symptoms, angiographic findings, procedural details, and adverse events at 30 days after PCI.RESULTS:Women (n = 161) were on average 8 years older than men (n = 405), had higher co-morbidity, were more often transported to the hospital by ambulance and presented less often to the emergency room on their own (4.2% vs. 12.6% in men, P = 0.02). The pre-hospital delay from symptom onset to admission was significantly longer for women (median 185 vs. 135 min, P < 0.02). There was no gender difference in time from admission to PCI (median 46 min vs. 48 min, P = 0.42). Both genders received PCI with similar frequency (88.8% vs. 92.4%, P = 0.19), with similar success rates (83.2% vs. 85.3%, P = 0.68). Thirty-day overall mortality for women was not significantly higher than for men (8.7% vs. 7.2%, P = 0.6). Re-infarction or stroke within 30 days were rare for both genders without gender-specific differences whereas bleeding necessitating blood replacement was significantly more frequent in women (16.8% vs. 5.9%, P < 0.001). In multivariate analysis, female gender was not independently associated with a higher risk of 30-day mortality (OR 0.964, P = 0.93).CONCLUSIONS:Women underwent PCI therapy for STEMI with the same frequency and the same angiographic success as men. Despite their more advanced age and the higher prevalence of co-morbidities, they did not have a significantly higher 30-day mortality rate than men. Female gender was not an independent risk factor of 30-day mortality. Longer pre-hospital delays before hospital admission in women indicate that awareness of risk from coronary artery disease should be further raised in women.
Nyckelord
- Kardiologi
- Cardiology
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- art (ämneskategori)
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Zimmermann, Stef ...
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Ruthrof, Susanne
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Nowak, Kathrin
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Alff, Anna
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Klinghammer, Lut ...
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Schneider, Reinh ...
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visa fler...
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Ludwig, Josef
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Pfahlberg, Annet ...
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Daniel, Werner G
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Flachskampf, Fra ...
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Clinical Researc ...
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Uppsala universitet