Pombe Cdc15 homology proteins: regulators of membrane dynamics and the actin cytoskeleton

Aspenström, PontusUppsala universitet,Ludwiginstitutet för cancerforskning (author)

Pombe Cdc15 homology proteins : regulators of membrane dynamics and the actin cytoskeleton

Pombe Cdc15 homology (PCH) proteins have emerged in many species as important coordinators of signalling pathways that regulate actomyosin assembly and membrane dynamics. For example, the prototype PCH protein, Cdc15p of Schizosaccharomyces pombe, has a role in assembly of the contractile ring, which is needed to separate dividing cells. Recently, mammalian PCH proteins have been found to bind phospholipids and to participate in membrane deformation. These findings suggest that PCH proteins are crucial linkers of membrane dynamics and actin polymerization, for example, during the internalization of transmembrane receptors. Intriguingly, some members of the PCH protein family are mutated in neurodegenerative and inflammatory diseases, which has implications for the identification of cures for such disorders.

Fransson, ÅsaUppsala universitet,Ludwiginstitutet för cancerforskning(Swepub:uu)asfra502 (author)
Richnau, NinnaUppsala universitet,Ludwiginstitutet för cancerforskning(Swepub:uu)ninarich (author)
Uppsala universitetLudwiginstitutet för cancerforskning (creator_code:org_t)

In:TIBS -Trends in Biochemical Sciences. Regular ed.: Elsevier BV31:12, s. 670-6790968-00041362-4326

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