Warfarin dose prediction in children using pharmacometric bridging: comparison with published pharmacogenetic dosing algorithms

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: WFRF:(Ekman Anna Karin) > Warfarin dose predi...

Details
MARC

Hamberg, Anna-Karin,1964-Uppsala universitet,Klinisk farmakogenomik och osteoporos (author)

Warfarin dose prediction in children using pharmacometric bridging : comparison with published pharmacogenetic dosing algorithms

Article/chapterEnglish2013

Publisher, publication year, extent ...

2013-01-11
Springer Science and Business Media LLC,2013
electronicrdacarrier

Numbers

LIBRIS-ID:oai:DiVA.org:uu-197596
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-197596URI
https://doi.org/10.1007/s00228-012-1466-4DOI
https://lup.lub.lu.se/record/3932502URI

Supplementary language notes

Language:English
Summary in:English

Part of subdatabase

SwePubSwePub

Classification

Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Correction in: EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY Volume: 69, Issue: 9, Pages: 1737-1737, DOI: 10.1007/s00228-013-1565-x
PurposeNumerous studies have investigated causes of warfarin dose variability in adults whereas studies in children are limited both in numbers and size. Mechanism-based population modelling provides an opportunity to condense and propagate prior knowledge from one population to another. The main objectives with this study were to evaluate the predictive performance of a theoretically bridged adult warfarin model in children, and to compare accuracy in dose prediction relative to published warfarin algorithms for children.MethodAn adult population PK/PD-model for warfarin, with CYP2C9 and VKORC1 genotype, age and target INR as dose predictors, was bridged to children using allometric scaling methods. Its predictive properties were evaluated in an external dataset of children 0-18 years old, including comparison of dose prediction accuracy with three pharmacogenetics-based algorithms for children.ResultsOverall, the bridged model predicted INR response well in 64 warfarin treated Swedish children (median age 4.3 years), but with a tendency to over predict INR in children ≤ 2 years old. The bridged model predicted 20 of 49 children (41%) within ± 20% of actual maintenance dose (median age 7.2 years). In comparison the published dosing algorithms predicted 33-41% of the children within ± 20% of actual dose. Dose optimization with the bridged model based on up to three individual INR observations increased the proportion within ± 20% of actual dose to 70%.ConclusionA mechanism-based population model developed on adult data provides a promising first step towards more individualized warfarin therapy in children.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmakologi och toxikologi hsv//swe
MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmacology and Toxicology hsv//eng
PK/PD model
Population analysis
Warfarin
Dosing
Children
Genotype
Clinical Pharmacology
Klinisk farmakologi
PK/PD model
Population analysis
Warfarin
Dosing
Children

Added entries (persons, corporate bodies, meetings, titles ...)

Friberg, Lena EUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)lenasimo (author)
Hanséus, KatarinaLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Barmhjärtcentrum, Skånes Universietessjukhus, Lund(Swepub:lu)pedi-kha (author)
Ekman-Joelsson, Britt-MarieDrottnings Silvias Barnsjukhus, Sahlgrenska Universitetssjukhuset, Göteborg (author)
Sunnegårdh, JanDrottnings Silvias Barnsjukhus, Sahlgrenska Universitetssjukhuset, Göteborg (author)
Jonzon, AndersUppsala universitet,Pediatrik(Swepub:uu)andersjz (author)
Lundell, BoAstrid Lindgrens Barnsjukhus, Stockholm (author)
Jonsson, E. NiclasUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)niklasjs (author)
Wadelius, MiaUppsala universitet,Klinisk farmakogenomik och osteoporos(Swepub:uu)miawadel (author)
Uppsala universitetKlinisk farmakogenomik och osteoporos (creator_code:org_t)

Related titles

In:European Journal of Clinical Pharmacology: Springer Science and Business Media LLC69:6, s. 1275-12830031-69701432-1041

Internet link

Find in a library

European Journal of Clinical Pharmacology (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Hamberg, Anna-Ka ...; Friberg, Lena E; Hanséus, Katarin ...; Ekman-Joelsson, ...; Sunnegårdh, Jan; Jonzon, Anders; show more...; Lundell, Bo; Jonsson, E. Nicl ...; Wadelius, Mia; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Pediatrics

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Pharmacology and ...

Articles in the publication: European Journal ...

By the university: Uppsala University; Lund University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se