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A single dose of ve...
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Erra, Elina O
(författare)
A single dose of vero cell-derived Japanese encephalitis (JE) vaccine (Ixiaro) effectively boosts immunity in travelers primed with mouse brain-derived JE vaccines
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
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2012-06-13
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Oxford University Press (OUP),2012
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-197813
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-197813URI
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https://doi.org/10.1093/cid/cis542DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:125190278URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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BACKGROUND:A significant part of the world population lives in areas with endemic Japanese encephalitis (JE). For travelers from nonendemic countries, Vero cell-derived vaccine (JE-VC; Ixiaro) has replaced traditional mouse brain-derived vaccines (JE-MB) associated with safety concerns. The 2 vaccines are derived from different viral strains: JE-VC from the SA14-14-2 strain and JE-MB from the Nakayama strain. No data exist regarding whether JE-VC can be used to boost immunity after a primary series of JE-MB; therefore, a primary series of JE-VC has been recommended to all travelers regardless of previous vaccination history.METHODS:One hundred twenty travelers were divided into 4 groups: Volunteers with no prior JE vaccination received primary immunization with (group 1) JE-MB or (group 2) JE-VC, and those primed with JE-MB received a single booster dose of (group 3) JE-MB or (group 4) JE-VC. Immune responses were tested before and 4-8 weeks after vaccination using plaque reduction neutralization test (PRNT) against both vaccine strains.RESULTS:In vaccine-naive travelers, the vaccination response rate for test strains Nakayama and SA14-14-2 was 100% and 87% after primary vaccination with JE-MB and 87% and 94% after JE-VC, respectively. Antibody levels depended on the target virus, with higher titers against homologous than heterologous PRNT(50) target strain (P < .001). In travelers primed with JE-MB, vaccination response rates were 91% and 91%, and 98% and 95% after a booster dose of JE-MB or JE-VC, respectively. Subgroup analysis revealed that a higher proportion of primed (98%/95%) than nonprimed (39%/42%) volunteers responded to a single dose of JE-VC (P < .001).CONCLUSIONS:A single dose of JE-VC effectively boosted immunity in JE-MB-primed travelers. Current recommendations should be reevaluated.CLINICAL TRIALS REGISTRATION:NCT01386827.
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Askling, Helena HerviusKarolinska Institutet
(författare)
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Rombo, LarsKarolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)(Swepub:uu)larra728
(författare)
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Riutta, Jukka
(författare)
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Vene, Sirkka
(författare)
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Yoksan, Sutee
(författare)
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Lindquist, LarsKarolinska Institutet
(författare)
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Pakkanen, Sari H
(författare)
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Huhtamo, Eili
(författare)
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Vapalahti, Olli
(författare)
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Kantele, AnuKarolinska Institutet
(författare)
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Karolinska InstitutetCentrum för klinisk forskning i Sörmland (CKFD)
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Clinical Infectious Diseases: Oxford University Press (OUP)55:6, s. 825-8341058-48381537-6591
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Erra, Elina O
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Askling, Helena ...
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Rombo, Lars
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Riutta, Jukka
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Vene, Sirkka
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Yoksan, Sutee
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visa fler...
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Lindquist, Lars
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Pakkanen, Sari H
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Huhtamo, Eili
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Vapalahti, Olli
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Kantele, Anu
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visa färre...
- Artiklar i publikationen
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Clinical Infecti ...
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Uppsala universitet
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Karolinska Institutet