The frequency of an IL-18-associated haplotype in Africans

Variation within the gene for the proinflammatory cytokine interleukin (IL)-18 has been associated with inter-individual differences in levels of free protein and disease risk. We investigated the frequency of function-associated IL18 gene haplotypes in an extensive sample (n=2357) of African populations from across the continent. A previously identified five tagging SNP (single-nucleotide polymorphism) haplotype (here designated hGTATA), known to be associated with lower levels of IL-18, was observed at a frequency of 27% in a British population of recent European ancestry, but was found at low frequency (<8%) or completely absent in African populations. Potentially protective variants may, as a consequence, be found at low frequency in African individuals and may confer a difference in disease risk.

Humphries, Steve E. (author)
Thomas, Mark G.Uppsala universitet,Evolutionsbiologi(Swepub:uu)marth133 (author)
Ekong, Rosemary (author)
Tarekegn, Ayele (author)
Bekele, Endeshaw (author)
Creemer, Olivia (author)
Bradman, Neil (author)
Veeramah, Krishna R. (author)
Uppsala universitetEvolutionsbiologi (creator_code:org_t)

In:European Journal of Human Genetics: Springer Science and Business Media LLC21:4, s. 465-4681018-48131476-5438

By the author/editor: Thompson, Simon ...; Humphries, Steve ...; Thomas, Mark G.; Ekong, Rosemary; Tarekegn, Ayele; Bekele, Endeshaw; show more...; Creemer, Olivia; Bradman, Neil; Veeramah, Krishn ...; show less...

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