Gastric Bypass Surgery Elevates NT-ProBNP Levels

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Sundbom Magnus) > Gastric Bypass Surg...

Abrahamsson, NiclasUppsala universitet,Endokrin diabetes och metabolism (författare)

Gastric Bypass Surgery Elevates NT-ProBNP Levels

Artikel/kapitelEngelska2013

Förlag, utgivningsår, omfång ...

2013-03-03
Springer Science and Business Media LLC,2013
printrdacarrier

Nummerbeteckningar

LIBRIS-ID:oai:DiVA.org:uu-199870
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-199870URI
https://doi.org/10.1007/s11695-013-0889-zDOI

Kompletterande språkuppgifter

Språk:engelska
Sammanfattning på:engelska

Ingår i deldatabas

SwePubSwePub

Klassifikation

Ämneskategori:ref swepub-contenttype
Ämneskategori:art swepub-publicationtype

Anmärkningar

BackgroundBrain natriuretic peptide (BNP) is produced in the heart in response to stretching of the myocardium. BNP levels are negatively correlated to obesity, and in obese subjects, a reduced BNP responsiveness has been described. Diet-induced weight loss has been found to lower or to have no effect on BNP levels, whereas gastric banding and gastric bypass have reported divergent results. We studied obese patients undergoing gastric bypass (GBP) surgery during follow-up of 1 year.MethodsTwenty patients, 18 women, mean 41 (SD 9.5) years old, with a mean preoperative BMI of 44.6 (SD 5.5) kg/m2 were examined. N-terminal pro-brain natriuretic peptide (NT-ProBNP), glucose and insulin were measured preoperatively, at day 6 and months 1, 6 and 12. In 14 of the patients, samples were also taken at days 1, 2 and 4.ResultsThe NT-ProBNP levels showed a marked increase during the postoperative week (from 54 pg/mL preop to 359 pg/mL on day 2 and fell to 155 on day 6). At 1 year, NT-ProBNP was 122 pg/mL (125 % increase, p = 0.01). Glucose, insulin and HOMA indices decreased shortly after surgery without correlation to NT-ProBNP change. Mean BMI was reduced from 44.6 to 30.5 kg/m2 at 1 year and was not related to NT-ProBNP change.ConclusionsThe data indicate that GBP surgery rapidly alters the tone of BNP release, by a mechanism not related to weight loss or to changes in glucometabolic parameters. The GBP-induced conversion of obese subjects, from low to high NT-ProBNP responders, is likely to influence the evaluation of cardiac function in GBP operated individuals.

Biuppslag (personer, institutioner, konferenser, titlar ...)

Engström, Britt EdénUppsala universitet,Endokrin diabetes och metabolism(Swepub:uu)brittee (författare)
Sundbom, MagnusUppsala universitet,Gastrointestinalkirurgi(Swepub:uu)magsundb (författare)
Karlsson, AndersUppsala universitet,Endokrin diabetes och metabolism(Swepub:uu)anderska (författare)
Uppsala universitetEndokrin diabetes och metabolism (creator_code:org_t)

Sammanhörande titlar

Ingår i:Obesity Surgery: Springer Science and Business Media LLC23:9, s. 1421-14260960-89231708-0428

Internetlänk

Hitta via bibliotek

Obesity Surgery (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Av författaren/redakt...: Abrahamsson, Nic ...; Engström, Britt ...; Sundbom, Magnus; Karlsson, Anders

Artiklar i publikationen: Obesity Surgery

Av lärosätet: Uppsala universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se