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The megalin receptor
The megalin receptor
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- Hjälm, Göran (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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(creator_code:org_t)
- ISBN 9155442536
- Uppsala : Acta Universitatis Upsaliensis, 1998
- Engelska 27 s.
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Serie: Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 0282-7476 ; 772
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Ionized calcium is a major player in the living organism. Its importance in both intra- and extracellular mechanisms have been studied in a broad number of publications. In man, the parathyroid glands have an essential role in the maintenance of a correct Ca2+-level in the blood serum by its ability to sense extracellular free Ca2+ and to modulate parathyroid hormone secretion. With the help of anti-parathyroid antibodies, previously shown to interfere with the parathyroid Ca2+-sensing mechanism, we have purified and cloned a human 520 kDa membrane bound receptor, megalin, implicated as a Ca2+-sensor. The primary structure of the receptor is characterized. Its possible involvement in Ca2+-regulation, but also in Alzheimer's disease and vitamin B12 metabolism is discussed.The cytoplasmic domain of megalin harbors a number of amino acid sequence motifs, potentially coupling the receptor to several intracellular signaling pathways. To further elucidate the organization of the cytoplasmic domain, we identified and sequenced a human genomic DNA clone encoding for this part of the receptor. The structure of this clone is characterized and discussed. In addition, one of the intronscontain a human endogenous retrovirus-like element of the HERV-H family. We show the presence of this element in the corresponding position in the genome of chimpanzee, gorilla, and orangutan, but absence in the African green monkey.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Nyckelord
- Biochemistry
- calcium
- parathyroid
- gp330
- megalin
- LRP-2
- LDL-receptor super family
- endogenous retroviruse
- Biokemi
- Biochemistry
- Biokemi
- Medical Biochemistry
- medicinsk biokemi
Publikations- och innehållstyp
- vet (ämneskategori)
- dok (ämneskategori)
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