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Effect of gene, env...
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Agnafors, SaraLinköpings universitet,Barn- och ungdomspsykiatri,Hälsouniversitetet
(författare)
Effect of gene, environment and maternal depressive symptoms on pre-adolescence behavior problems : a longitudinal study
- Artikel/kapitelEngelska2013
Förlag, utgivningsår, omfång ...
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Springer Science and Business Media LLC,2013
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-200314
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-200314URI
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https://doi.org/10.1186/1753-2000-7-10DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-104869URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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BACKGROUND:Depression is a common and disabling condition with a high relapse frequency. Maternal mental health problems and experience of traumatic life events are known to increase the risk of behavior problems in children. Recently, genetic factors, in particular gene-by-environment interaction models, have been implicated to explain depressive etiology. However, results are inconclusive.METHODS:Study participants were members of the SESBiC-study. A total of 889 mothers and their children were followed during the child's age of 3 months to 12 years. Information on maternal depressive symptoms was gathered postpartum and at a 12 year follow-up. Mothers reported on child behavior and traumatic life events experienced by the child at age 12. Saliva samples were obtained from children for analysis of 5-HTTLPR and BDNF Val66Met polymorphisms.RESULTS:Multivariate analysis showed a significant association between maternal symptoms of depression and anxiety, and internalizing problems in 12-year-old children (OR 5.72, 95% CI 3.30-9.91). Furthermore, carriers of two short alleles (s/s) of the 5-HTTLPR showed a more than 4-fold increased risk of internalizing problems at age 12 compared to l/l carriers (OR 4.73, 95% CI 2.14-10.48). No gene-by-environment interaction was found and neither depressive symptoms postpartum or traumatic experiences during childhood stayed significant in the final model.CONCLUSIONS:Concurrent maternal symptoms of depression and anxiety are significant risk factors for behavior problems in children, which need to be taken into account in clinical practice. Furthermore, we found a main effect of 5-HTTLPR on internalizing symptoms in 12-year-old children, a finding that needs to be confirmed in future studies.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Comasco, ErikaUppsala universitet,Neuropsykofarmakologi,Division of Pharmacology, Department of Neuroscience, Uppsala University, Uppsala, Sweden(Swepub:uu)erico267
(författare)
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Bladh, MarieÖstergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping(Swepub:liu)marbl97
(författare)
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Sydsjö, GunillaÖstergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Kvinnokliniken i Linköping(Swepub:liu)gunsy68
(författare)
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Dekeyser, LindaLinköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet
(författare)
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Oreland, LarsUppsala universitet,Neuropsykofarmakologi,Division of Pharmacology, Department of Neuroscience, Uppsala University, Uppsala, Sweden(Swepub:uu)larsore
(författare)
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Svedin, Carl GöranLinköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet(Swepub:liu)carsv67
(författare)
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Linköpings universitetBarn- och ungdomspsykiatri
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Child and Adolescent Psychiatry and Mental Health: Springer Science and Business Media LLC71753-2000
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