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Effect of gene, env...
Effect of gene, environment and maternal depressive symptoms on pre-adolescence behavior problems : a longitudinal study
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- Agnafors, Sara (author)
- Linköpings universitet,Barn- och ungdomspsykiatri,Hälsouniversitetet
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- Comasco, Erika (author)
- Uppsala universitet,Neuropsykofarmakologi,Division of Pharmacology, Department of Neuroscience, Uppsala University, Uppsala, Sweden
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- Bladh, Marie (author)
- Östergötlands Läns Landsting,Linköpings universitet,Obstetrik och gynekologi,Hälsouniversitetet,Kvinnokliniken i Linköping
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- Sydsjö, Gunilla (author)
- Östergötlands Läns Landsting,Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet,Kvinnokliniken i Linköping
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- Dekeyser, Linda (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet
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- Oreland, Lars (author)
- Uppsala universitet,Neuropsykofarmakologi,Division of Pharmacology, Department of Neuroscience, Uppsala University, Uppsala, Sweden
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- Svedin, Carl Göran (author)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet
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(creator_code:org_t)
- Springer Science and Business Media LLC, 2013
- 2013
- English.
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In: Child and Adolescent Psychiatry and Mental Health. - : Springer Science and Business Media LLC. - 1753-2000. ; 7
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Abstract
Subject headings
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- BACKGROUND:Depression is a common and disabling condition with a high relapse frequency. Maternal mental health problems and experience of traumatic life events are known to increase the risk of behavior problems in children. Recently, genetic factors, in particular gene-by-environment interaction models, have been implicated to explain depressive etiology. However, results are inconclusive.METHODS:Study participants were members of the SESBiC-study. A total of 889 mothers and their children were followed during the child's age of 3 months to 12 years. Information on maternal depressive symptoms was gathered postpartum and at a 12 year follow-up. Mothers reported on child behavior and traumatic life events experienced by the child at age 12. Saliva samples were obtained from children for analysis of 5-HTTLPR and BDNF Val66Met polymorphisms.RESULTS:Multivariate analysis showed a significant association between maternal symptoms of depression and anxiety, and internalizing problems in 12-year-old children (OR 5.72, 95% CI 3.30-9.91). Furthermore, carriers of two short alleles (s/s) of the 5-HTTLPR showed a more than 4-fold increased risk of internalizing problems at age 12 compared to l/l carriers (OR 4.73, 95% CI 2.14-10.48). No gene-by-environment interaction was found and neither depressive symptoms postpartum or traumatic experiences during childhood stayed significant in the final model.CONCLUSIONS:Concurrent maternal symptoms of depression and anxiety are significant risk factors for behavior problems in children, which need to be taken into account in clinical practice. Furthermore, we found a main effect of 5-HTTLPR on internalizing symptoms in 12-year-old children, a finding that needs to be confirmed in future studies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Child
- Depression
- 5-HTTLPR
- BDNF
- Longitudinal
- SESBiC-study
Publication and Content Type
- ref (subject category)
- art (subject category)
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