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Moving beyond essential interventions for reduction of maternal mortality (the WHO Multicountry Survey on Maternal and Newborn Health) : a cross-sectional study

Souza, João Paulo (författare)
UNDP/UNFPA/UNICEF/WHO/Word Bank Special Programme of Research, Development and Research Training in Human Reproduction, WHO, Geneva, Switzerland
Gülmezoglu, Ahmet Metin (författare)
UNDP/UNFPA/UNICEF/WHO/Word Bank Special Programme of Research, Development and Research Training in Human Reproduction, WHO, Geneva, Switzerland
Vogel, Joshua (författare)
UNDP/UNFPA/UNICEF/WHO/Word Bank Special Programme of Research, Development and Research Training in Human Reproduction, WHO, Geneva, Switzerland
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Carroli, Guillermo (författare)
Centro Rosarino de Estudios Perinatales, Rosario, Argentina
Lumbiganon, Pisake (författare)
Khon Kaen University, Khon Kaen, Thailand
Qureshi, Zahida (författare)
University of Nairobi, Nairobi, Kenya
Costa, Maria José (författare)
WHO Angola, Luanda, Angola
Fawole, Bukola (författare)
University of Ibadan, Ibadan, Nigeria
Mugerwa, Yvonne (författare)
Makerere University, Makerere, Uganda
Nafiou, Idi (författare)
Université Abdou Moumouni de Niamey, Niamey, Niger
Neves, Isilda (författare)
Delegação Provincial de Saúde de Luanda, Luanda, Angola
Wolomby-Molondo, Jean-José (författare)
Cliniques Universitaires de Kinshasa, Kinshasa, DR Congo
Bang, Hoang Thi (författare)
WHO, Hanoi, Vietnam
Cheang, Kannitha (författare)
WHO, Phnom Penh, Cambodia
Chuyun, Kang (författare)
Peking University, Beijing, China
Jayaratne, Kapila (författare)
Ministry of Health, Government of Sri Lanka, Colombo, Sri Lanka
Jayathilaka, Chandani Anoma (författare)
WHO, Colombo, Sri Lanka
Mazhar, Syeda Batool (författare)
Pakistan Institute of Medical Sciences, Islamabad, Pakistan
Mori, Rintaro (författare)
Department of Health Policy, National Center for Child Health and Development, Tokyo, Japan
Mustafa, Mir Lais (författare)
Afghan Public Health Institute, Kabul, Afghanistan
Pathak, Laxmi Raj (författare)
Ministry of Health and Population, Government of Nepal, Kathmandu, Nepal
Perera, Deepthi (författare)
Ministry of Health, Government of Sri Lanka, Colombo, Sri Lanka
Rathavy, Tung (författare)
National Maternal and Child Health Center, Phnom Penh, Cambodia
Recidoro, Zenaida (författare)
National Center for Disease Prevention and Control, Manila, Philippines
Roy, Malabika (författare)
Indian Council of Medical Research, New Delhi, India
Ruyan, Pang (författare)
Peking University, Beijing, China
Shrestha, Naveen (författare)
Central Institute of Science and Technology (CIST) College, Pokhara University, Kathmandu, Nepal
Taneepanichsku, Surasak (författare)
Chulalongkorn University, Bangkok, Thailand
Tien, Nguyen Viet (författare)
National Obstetrics and Gynaecology Hospital, Hanoi, Vietnam
Ganchimeg, Togoobaatar (författare)
The University of Tokyo, Tokyo, Japan
Wehbe, Mira (författare)
American University of Beirut, Beirut, Lebanon
Yadamsuren, Buyanjargal (författare)
Ministry of Health, Government of Mongolia, Ulaanbaatar, Mongolia
Yan, Wang (författare)
Peking University, Beijing, China
Yunis, Khalid (författare)
American University of Beirut, Beirut, Lebanon
Bataglia, Vicente (författare)
Hospital Nacional de Itauguá, Itauguá, Paraguay
Cecatti, José Guilherme (författare)
University of Campinas, Campinas, SP, Brazil
Hernandez-Prado, Bernardo (författare)
Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA
Nardin, Juan Manuel (författare)
Centro Rosarino de Estudios Perinatales, Rosario, Argentina
Narváez, Alberto (författare)
Colegio Medico de Pichincha and Fundación Salud, Ambiente y Desarollo, Pichincha, Ecuador
Ortiz-Panozo, Eduardo (författare)
Instituto Nacional de Salud Pública, Cuernavaca, Mexico
Pérez-Cuevas, Ricardo (författare)
Social Protection and Health Division, Inter American Development Bank, Mexico City, Mexico
Valladares, Eliette (författare)
Universidad Nacional Autónoma de Nicaragua, León, Nicaragua
Zavaleta, Nelly (författare)
Instituto de Investigación Nutricional, Lima, Peru
Armson, Anthony (författare)
Dalhousie University, Halifax, Canada
Crowther, Caroline (författare)
University of Adelaide, Adelaide, Australia
Hogue, Carol (författare)
Emory University, Atlanta, GA, USA
Lindmark, Gunilla, 1941- (författare)
Uppsala universitet,Internationell mödra- och barnhälsovård (IMCH),Internationell kvinno- & mödrahälsovård/Essén
Mittal, Suneeta (författare)
All India Institute of Medical Sciences, New Delhi, India
Pattinson, Robert (författare)
University of Pretoria, Pretoria, South Africa
Stanton, Mary Ellen (författare)
United States Agency for International Development, Washington, DC, USA
Campodonico, Liana (författare)
Centro Rosarino de Estudios Perinatales, Rosario, Argentina
Cuesta, Cristina (författare)
Centro Rosarino de Estudios Perinatales, Rosario, Argentina
Giordano, Daniel (författare)
Centro Rosarino de Estudios Perinatales, Rosario, Argentina
Intarut, Nirun (författare)
Chulalongkorn University, Bangkok, Thailand
Laopaiboon, Malinee (författare)
Khon Kaen University, Khon Kaen, Thailand
Bahl, Rajiv (författare)
WHO, Geneva, Switzerland
Martines, Jose (författare)
WHO, Geneva, Switzerland
Mathai, Matthews (författare)
WHO, Geneva, Switzerland
Merialdi, Mario (författare)
UNDP/UNFPA/UNICEF/WHO/Word Bank Special Programme of Research, Development and Research Training in Human Reproduction, WHO, Geneva, Switzerland
Say, Lale (författare)
UNDP/UNFPA/UNICEF/WHO/Word Bank Special Programme of Research, Development and Research Training in Human Reproduction, WHO, Geneva, Switzerland
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 (creator_code:org_t)
2013
2013
Engelska.
Ingår i: The Lancet. - 0140-6736 .- 1474-547X. ; 381:9879, s. 1747-1755
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • BACKGROUND: We report the main findings of the WHO Multicountry Survey on Maternal and Newborn Health (WHOMCS), which aimed to assess the burden of complications related to pregnancy, the coverage of key maternal health interventions, and use of the maternal severity index (MSI) in a global network of health facilities.METHODS: In our cross-sectional study, we included women attending health facilities in Africa, Asia, Latin America, and the Middle East that dealt with at least 1000 childbirths per year and had the capacity to provide caesarean section. We obtained data from analysis of hospital records for all women giving birth and all women who had a severe maternal outcome (SMO; ie, maternal death or maternal near miss). We regarded coverage of key maternal health interventions as the proportion of the target population who received an indicated intervention (eg, the proportion of women with eclampsia who received magnesium sulphate). We used areas under the receiver operator characteristic curves (AUROC) with 95% CI to externally validate a previously reported MSI as an indicator of severity. We assessed the overall performance of care (ie, the ability to produce a positive effect on health outcomes) through standardised mortality ratios.RESULTS: From May 1, 2010, to Dec 31, 2011, we included 314,623 women attending 357 health facilities in 29 countries (2538 had a maternal near miss and 486 maternal deaths occurred). The mean period of data collection in each health facility was 89 days (SD 21). 23,015 (7.3%) women had potentially life-threatening disorders and 3024 (1.0%) developed an SMO. 808 (26.7%) women with an SMO had post-partum haemorrhage and 784 (25.9%) had pre-eclampsia or eclampsia. Cardiovascular, respiratory, and coagulation dysfunctions were the most frequent organ dysfunctions in women who had an SMO. Reported mortality in countries with a high or very high maternal mortality ratio was two-to-three-times higher than that expected for the assessed severity despite a high coverage of essential interventions. The MSI had good accuracy for maternal death prediction in women with markers of organ dysfunction (AUROC 0.826 [95% CI 0.802-0.851]).INTERPRETATION: High coverage of essential interventions did not imply reduced maternal mortality in the health-care facilities we studied. If substantial reductions in maternal mortality are to be achieved, universal coverage of life-saving interventions need to be matched with comprehensive emergency care and overall improvements in the quality of maternal health care. The MSI could be used to assess the performance of health facilities providing care to women with complications related to pregnancy.

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