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  • Fugier, Charlotte (author)

Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • 2011-05-29
  • Springer Science and Business Media LLC,2011
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-203346
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-203346URI
  • https://doi.org/10.1038/nm.2374DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • These authors contributed equally to this work: Charlotte Fugier, Arnaud F Klein & Caroline Hammer
  • Myotonic dystrophy is the most common muscular dystrophy in adults and the first recognized example of an RNA-mediated disease. Congenital myotonic dystrophy (CDM1) and myotonic dystrophy of type 1 (DM1) or of type 2 (DM2) are caused by the expression of mutant RNAs containing expanded CUG or CCUG repeats, respectively. These mutant RNAs sequester the splicing regulator Muscleblind-like-1 (MBNL1), resulting in specific misregulation of the alternative splicing of other pre-mRNAs. We found that alternative splicing of the bridging integrator-1 (BIN1) pre-mRNA is altered in skeletal muscle samples of people with CDM1, DM1 and DM2. BIN1 is involved in tubular invaginations of membranes and is required for the biogenesis of muscle T tubules, which are specialized skeletal muscle membrane structures essential for excitation-contraction coupling. Mutations in the BIN1 gene cause centronuclear myopathy, which shares some histopathological features with myotonic dystrophy. We found that MBNL1 binds the BIN1 pre-mRNA and regulates its alternative splicing. BIN1 missplicing results in expression of an inactive form of BIN1 lacking phosphatidylinositol 5-phosphate-binding and membrane-tubulating activities. Consistent with a defect of BIN1, muscle T tubules are altered in people with myotonic dystrophy, and membrane structures are restored upon expression of the normal splicing form of BIN1 in muscle cells of such individuals. Finally, reproducing BIN1 splicing alteration in mice is sufficient to promote T tubule alterations and muscle weakness, a predominant feature of myotonic dystrophy.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Klein, Arnaud F (author)
  • Hammer, Caroline (author)
  • Vassilopoulos, Stéphane (author)
  • Ivarsson, YlvaKU Leuven,Ivarsson(Swepub:uu)yliva676 (author)
  • Toussaint, Anne (author)
  • Tosch, Valérie (author)
  • Vignaud, Alban (author)
  • Ferry, Arnaud (author)
  • Messaddeq, Nadia (author)
  • Kokunai, Yosuke (author)
  • Tsuburaya, Rie (author)
  • de la Grange, Pierre (author)
  • Dembele, Doulaye (author)
  • Francois, Virginie (author)
  • Precigout, Guillaume (author)
  • Boulade-Ladame, Charlotte (author)
  • Hummel, Marie-Christine (author)
  • Lopez de Munain, Adolfo (author)
  • Sergeant, Nicolas (author)
  • Laquerrière, Annie (author)
  • Thibault, Christelle (author)
  • Deryckere, François (author)
  • Auboeuf, Didier (author)
  • Garcia, Luis (author)
  • Zimmermann, Pascale (author)
  • Udd, Bjarne (author)
  • Schoser, Benedikt (author)
  • Takahashi, Masanori P (author)
  • Nishino, Ichizo (author)
  • Bassez, Guillaume (author)
  • Laporte, Jocelyn (author)
  • Furling, Denis (author)
  • Charlet-Berguerand, Nicolas (author)
  • KU LeuvenIvarsson (creator_code:org_t)

Related titles

  • In:Nature medicine: Springer Science and Business Media LLC17:6, s. 720-7251546-170X1078-8956

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