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Effects of an isoca...
Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome : a randomized study (SYSDIET)
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- Uusitupa, M. (författare)
- Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Research Unit, Kuopio University Hospital, Kuopio, Finland
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- Hermansen, K. (författare)
- Department of Medicine and Endocrinology MEA, Aarhus University Hospital, Aarhus, Denmark
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- Savolainen, M. J. (författare)
- Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland
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visa fler...
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- Schwab, U. (författare)
- Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Institute of Clinical Medicine, Internal Medicine, Kuopio University Hospital, Kuopio, Finland
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- Kolehmainen, M. (författare)
- Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
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- Brader, L. (författare)
- Department of Medicine and Endocrinology MEA, Aarhus University Hospital, Aarhus, Denmark
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- Mortensen, L. S. (författare)
- Department of Medicine and Endocrinology MEA, Aarhus University Hospital, Aarhus, Denmark
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- Cloetens, Lieselotte (författare)
- Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Johansson Persson, Anna (författare)
- Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Önning, Gunilla (författare)
- Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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- Landin-Olsson, Mona (författare)
- Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Herzig, K. -H (författare)
- Institute of Biomedicine and Biocenter of Oulu, University of Oulu, Oulu, Finland; Department of Psychiatry, Kuopio University Hospital, Kuopio, Finland
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- Hukkanen, J. (författare)
- Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland
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- Rosqvist, Fredrik (författare)
- Uppsala universitet,Klinisk nutrition och metabolism,Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden
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- Iggman, David (författare)
- Uppsala universitet,Klinisk nutrition och metabolism,Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden; Center for Clinical Research Dalarna, Falun, Sweden
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- Paananen, J. (författare)
- Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
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- Pulkki, K. J. (författare)
- Eastern Finland Laboratory Centre and Department of Clinical Chemistry, University of Eastern Finland, Kuopio, Finland
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- Siloaho, M. (författare)
- Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland; Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
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- Dragsted, L. (författare)
- Department of Nutrition, Exercise and Sport, University of Copenhagen, Copenhagen, Denmark
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- Barri, T. (författare)
- Department of Nutrition, Exercise and Sport, University of Copenhagen, Copenhagen, Denmark
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- Overvad, K. (författare)
- Department of Epidemiology, School of Public Health, Aarhus University, Aarhus, Denmark; Department of Cardiology, Aalborg Hospital, Aarhus University Hospital, Aarhus, Denmark
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- Knudsen, K. E. Bach (författare)
- Department of Animal Science, Aarhus University, Aarhus, Denmark
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- Hedemann, M. S. (författare)
- Department of Animal Science, Aarhus University, Aarhus, Denmark
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- Arner, P. (författare)
- Karolinska Institutet
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- Dahlman, I. (författare)
- Karolinska Institutet
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- Borge, G. I. A. (författare)
- Nofima, Norwegian Institute of Food, Fisheries and Aquaculture Research, Ås, Norway,Unit for Nutrition Research, University of Iceland and Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland
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- Baardseth, P. (författare)
- Nofima, Norwegian Institute of Food, Fisheries and Aquaculture Research, Ås, Norway
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- Ulven, S. M. (författare)
- Department of Health, Nutrition and Management, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, Oslo, Norway
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Gunnarsdottir, I. (författare)
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- Jonsdottir, S. (författare)
- Unit for Nutrition Research, University of Iceland and Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland
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- Thorsdottir, I. (författare)
- Unit for Nutrition Research, University of Iceland and Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland
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- Oresic, Matej, 1967- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Unit for Nutrition Research, University of Iceland and Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland
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- Poutanen, K. S. (författare)
- Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; VTT Technical Research Centre of Finland, Espoo, Finland
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- Risérus, Ulf (författare)
- Uppsala universitet,Klinisk nutrition och metabolism,Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden
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- Åkesson, Björn (författare)
- Lund University,Lunds universitet,Tillämpad biokemi,Centrum för tillämpade biovetenskaper,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Pure and Applied Biochemistry,Center for Applied Life Sciences,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH
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, ring (författare)
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(creator_code:org_t)
- 2013-03-02
- 2013
- Engelska.
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Ingår i: Journal of Internal Medicine. - : Wiley. - 0954-6820 .- 1365-2796. ; 274:1, s. 52-66
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Abstract
Ämnesord
Stäng
- Background Different healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome. Methods We conducted a randomized dietary study lasting for 18-24weeks in individuals with features of metabolic syndrome (mean age 55years, BMI 31.6kgm-2, 67% women). Altogether 309 individuals were screened, 200 started the intervention after 4-week run-in period, and 96 (proportion of dropouts 7.9%) and 70 individuals (dropouts 27%) completed the study, in the Healthy diet and Control diet groups, respectively. Healthy diet included whole-grain products, berries, fruits and vegetables, rapeseed oil, three fish meals per week and low-fat dairy products. An average Nordic diet served as a Control diet. Compliance was monitored by repeated 4-day food diaries and fatty acid composition of serum phospholipids. Results Body weight remained stable, and no significant changes were observed in insulin sensitivity or blood pressure. Significant changes between the groups were found in non-HDL cholesterol (-0.18, mmolL-1 95% CI -0.35; -0.01, P=0.04), LDL to HDL cholesterol (-0.15, -0.28; -0.00, P=0.046) and apolipoprotein B to apolipoprotein A1 ratios (-0.04, -0.07; -0.00, P=0.025) favouring the Healthy diet. IL-1 Ra increased during the Control diet (difference -84, -133; -37ngL-1, P= 0.00053). Intakes of saturated fats (E%, beta estimate 4.28, 0.02; 8.53, P=0.049) and magnesium (mg, -0.23, -0.41; -0.05, P=0.012) were associated with IL-1 Ra. Conclusions Healthy Nordic diet improved lipid profile and had a beneficial effect on low-grade inflammation.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- cardiovascular risk
- inflammation
- intervention
- metabolic syndrome
- Nordic diet
- cardiovascular risk
- inflammation
- intervention
- metabolic syndrome
- Nordic diet
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Uusitupa, M.
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Hermansen, K.
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Savolainen, M. J ...
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Schwab, U.
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Kolehmainen, M.
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Brader, L.
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visa fler...
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Mortensen, L. S.
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Cloetens, Liesel ...
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Johansson Persso ...
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Önning, Gunilla
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Landin-Olsson, M ...
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Herzig, K. -H
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Hukkanen, J.
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Rosqvist, Fredri ...
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Iggman, David
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Paananen, J.
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Pulkki, K. J.
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Siloaho, M.
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Dragsted, L.
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Barri, T.
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Overvad, K.
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Knudsen, K. E. B ...
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Hedemann, M. S.
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Arner, P.
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Dahlman, I.
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Borge, G. I. A.
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Baardseth, P.
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Ulven, S. M.
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Gunnarsdottir, I ...
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Jonsdottir, S.
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Thorsdottir, I.
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Oresic, Matej, 1 ...
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Poutanen, K. S.
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Risérus, Ulf
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Åkesson, Björn
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Uppsala universitet
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