Search: L773:1879 0089 OR L773:0145 305X >
IgA deficiency in w...
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Frankowiack, MarcelKarolinska Institutet
(author)
IgA deficiency in wolves
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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Elsevier BV,2013
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-204119
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-204119URI
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https://doi.org/10.1016/j.dci.2013.01.005DOI
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https://res.slu.se/id/publ/40831URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:126864897URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Low mean concentrations of serum immunoglobulin A (IgA) and an increased frequency of overt IgA deficiency (IgAD) in certain dog breeds raises the question whether it is a breeding-enriched phenomenon or a legacy from the dog's ancestor, the gray wolf (Canis lupus). The IgA concentration in 99 serum samples from 58 free-ranging and 13 captive Scandinavian wolves, was therefore measured by capture ELISA. The concentrations were markedly lower in the wolf serum samples than in the dog controls. Potential differences in the IgA molecule between dogs and wolves were addressed by sequencing the wolf IgA heavy chain constant region encoding gene (IGHA). Complete amino acid sequence homology was found. Detection of wolf and dog IgA was ascertained by showing identity using double immunodiffusion. We suggest that the vast majority of wolves, the ancestor of the dog, are IgA deficient.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Hellman, LarsUppsala universitet,Kemisk biologi(Swepub:uu)larshell
(author)
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Zhao, Yaofeng
(author)
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Arnemo, JonSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för vilt, fisk och miljö,Department of Wildlife, Fish and Environmental Studies,Hedmark University College(Swepub:slu)49057
(author)
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Lin, Miaoli
(author)
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Tengvall, KatarinaUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala University(Swepub:slu)49591
(author)
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Moller, Torsten
(author)
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Lindblad-Toh, KerstinUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)kerli865
(author)
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Hammarstrom, LennartKarolinska Institutet
(author)
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Karolinska InstitutetKemisk biologi
(creator_code:org_t)
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Sveriges lantbruksuniversitet
Related titles
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In:Developmental and Comparative Immunology: Elsevier BV40:2, s. 180-1840145-305X1879-0089
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