Search: id:"swepub:oai:DiVA.org:uu-204832" >
Gene-nutrient inter...
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Perez-Martinez, Pablo
(author)
Gene-nutrient interactions on the phosphoenolpyruvate carboxykinase influence insulin sensitivity in metabolic syndrome subjects
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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Elsevier BV,2013
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-204832
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-204832URI
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https://doi.org/10.1016/j.clnu.2012.10.003DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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De två (2) första författarna delar förstaförfattarskapet.De två (2) sista författarna delar sistaförfattarskapet.
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Background & aims: Genetic background may interact with habitual dietary fat composition, and affect development of the metabolic syndrome (MetS). The phosphoenolpyruvate carboxykinase gene (PCK1) plays a significant role regulating glucose metabolism, and fatty acids are key metabolic regulators, which interact with transcription factors and influence glucose metabolism. We explored genetic variability at the PCK1 gene locus in relation to degree of insulin resistance and plasma fatty acid levels in MetS subjects. Moreover, we analyzed the PCK1 gene expression in the adipose tissue of a subgroup of MetS subjects according to the PCK1 genetic variants. Methods: Insulin sensitivity, insulin secretion, glucose effectiveness, plasma concentrations of C-peptide, fatty acid composition and three PCK1 tag-single nucleotide polymorphisms (SNPs) were determined in 443 MetS participants in the UPGENE cohort. Results: The rs2179706 SNP interacted with plasma concentration of n - 3 polyunsaturated fatty acids (n - 3 PUFA), which were significantly associated with plasma concentrations of fasting insulin, peptide C, and HOMA-IR. Among subjects with n - 3 PUFA levels above the population median, carriers of the C/C genotype exhibited lower plasma concentrations of fasting insulin (P = 0.036) and HOMA-IR (P = 0.019) as compared with C/C carriers with n - 3 PUFA below the median. Moreover, homozygous C/C subjects with n - 3 PUFA levels above the median showed lower plasma concentrations of peptide C as compared to individuals with the T-allele (P = 0.006). Subjects carrying the T-allele showed a lower gene PCK1 expression as compared with carriers of the C/C genotype (P = 0.015). Conclusions: The PCK1 rs2179706 polymorphism interacts with plasma concentration of n - 3 PUFA levels modulating insulin resistance in MetS subjects.
Subject headings and genre
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HOMA-IR
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Metabolic syndrome
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n-3 polyunsaturated fatty acids
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PCK1 gene
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Adipose tissue
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Nutrigenetics
Added entries (persons, corporate bodies, meetings, titles ...)
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Garcia-Rios, Antonio
(author)
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Delgado-Lista, Javier
(author)
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Gjelstad, Ingrid M. F.
(author)
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Gibney, James
(author)
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Kiec-Wilk, Beata
(author)
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Camargo, Antonio
(author)
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Helal, Olfa
(author)
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Karlström, BritaUppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)britkarl
(author)
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Blaak, Ellen E.
(author)
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Hall, Wendy
(author)
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Risérus, UlfUppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)ulfriser
(author)
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Dembinska-Kiec, Aldona
(author)
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Defoort, Catherine
(author)
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Saris, Wim H. M.
(author)
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Lovegrove, Julie A.
(author)
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Drevon, Christian A.
(author)
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Roche, Helen M.
(author)
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Lopez-Miranda, Jose
(author)
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Uppsala universitetKlinisk nutrition och metabolism
(creator_code:org_t)
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In:Clinical Nutrition: Elsevier BV32:4, s. 630-6350261-56141532-1983
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Gibney, James
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Kiec-Wilk, Beata
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Camargo, Antonio
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Helal, Olfa
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Karlström, Brita
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Blaak, Ellen E.
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Hall, Wendy
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Risérus, Ulf
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Dembinska-Kiec, ...
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Defoort, Catheri ...
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Saris, Wim H. M.
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Lovegrove, Julie ...
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Drevon, Christia ...
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Roche, Helen M.
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Lopez-Miranda, J ...
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