Sökning: WFRF:(Arvidson Johan 1953 ) >
Self-reported quali...
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Sundberg, Kay K.Karolinska Institutet
(författare)
Self-reported quality of life in long-term survivors of childhood lymphoblastic malignancy treated with hematopoietic stem cell transplantation versus conventional therapy
- Artikel/kapitelEngelska2013
Förlag, utgivningsår, omfång ...
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2013-03-20
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Wiley,2013
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-204849
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-204849URI
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https://doi.org/10.1002/pbc.24519DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:126953112URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Background Chronic health conditions are known to be both abundant and severe after pediatric hematopoietic stem cell transplantation (SCT). The present objective was to investigate the impact of disease and treatment on individual QoL and health-related quality of life (HRQoL) in long-term survivors of childhood lymphoblastic malignancy treated with conventional therapy versus SCT. Procedure Survivors of lymphoblastic malignancy treated with (n=18) or without (n=52) SCT were recruited a median follow-up time of 18 and 14 years, respectively. The indication for SCT was relapsed disease in 17 of 18 cases. Autologous stem cells were used in 15 cases. Total body irradiation (TBI) was included in the conditioning regimen for all SCT patients. A cross-sectional study was conducted using two validated instruments: SEIQoL-DW (individual QoL) and SF-36 (HRQoL). Content analysis was used to analyze SEIQoL-DW and an overall QoL index score was calculated. Two multiple linear regression analyses were performed to detect factors influencing outcomes. Results Poorer ratings of overall QoL and more negative consequences related to physical dysfunctions were shown in the SCT group. The findings indicate that being unemployed or on sick leave are associated with a decline in HRQoL and individual QoL rather than SCT, cranial radiation therapy, present age, or sex. Conclusion In this small sample of long-term survivors of SCT, QoL seems reasonably good and similar to that of those having received conventional therapy. However, managing an employment must be acknowledged as an important part of life that has a great impact on QoL.
Ämnesord och genrebeteckningar
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long-term survivors
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lymphoblastic malignancy
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quality of life
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stem cell transplantation
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Wettergren, LenaKarolinska Institutet
(författare)
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Frisk, P,1966-Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnonkologisk forskning/Pfeifer(Swepub:uu)pefri226
(författare)
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Arvidson, Johan,1953-Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnonkologisk forskning/Pfeifer(Swepub:uu)johanas
(författare)
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Karolinska InstitutetInstitutionen för kvinnors och barns hälsa
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Pediatric Blood & Cancer: Wiley60:8, s. 1382-13871545-50091545-5017
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