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The Long-Term Multi...
The Long-Term Multicenter Observational Study of Dabigatran Treatment in Patients With Atrial Fibrillation (RELY-ABLE) Study
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Connolly, Stuart J. (author)
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- Wallentin, Lars (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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Ezekowitz, Michael D. (author)
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show more...
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Eikelboom, John (author)
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- Oldgren, Jonas (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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Reilly, Paul A. (author)
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Brueckmann, Martina (author)
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Pogue, Janice (author)
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Alings, Marco (author)
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Amerena, John V. (author)
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Avezum, Alvaro (author)
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Baumgartner, Iris (author)
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Budaj, Andrzej J. (author)
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Chen, Jyh-Hong (author)
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Dans, Antonio L. (author)
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Darius, Harald (author)
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Di Pasquale, Giuseppe (author)
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Ferreira, Jorge (author)
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Flaker, Greg C. (author)
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Flather, Marcus D. (author)
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Franzosi, Maria Grazia (author)
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Golitsyn, Sergey P. (author)
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Halon, David A. (author)
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Heidbuchel, Hein (author)
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Hohnloser, Stefan H. (author)
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Huber, Kurt (author)
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Jansky, Petr (author)
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Kamensky, Gabriel (author)
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Keltai, Matyas (author)
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Kim, Sung Soon (author)
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Lau, Chu-Pak (author)
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Le Heuzey, Jean-Yves (author)
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Lewis, Basil S. (author)
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Liu, Lisheng (author)
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Nanas, John (author)
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Omar, Razali (author)
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Pais, Prem (author)
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Pedersen, Knud E. (author)
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Piegas, Leopoldo S. (author)
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Raev, Dimitar (author)
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Smith, Pal J. (author)
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Talajic, Mario (author)
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Tan, Ru San (author)
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Tanomsup, Supachai (author)
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Toivonen, Lauri (author)
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Vinereanu, Dragos (author)
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Xavier, Denis (author)
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Zhu, Jun (author)
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Wang, Susan Q. (author)
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Duffy, Christine O. (author)
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Themeles, Ellison (author)
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Yusuf, Salim (author)
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(creator_code:org_t)
- 2013
- 2013
- English.
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In: Circulation. - 0009-7322 .- 1524-4539. ; 128:3, s. 237-243
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Background During follow-up of between 1 and 3 years in the Randomized Evaluation of Long-term Anticoagulation Therapy (RE-LY) trial, 2 doses of dabigatran etexilate were shown to be effective and safe for the prevention of stroke or systemic embolism in patients with atrial fibrillation. There is a need for longer-term follow-up of patients on dabigatran and for further data comparing the 2 dabigatran doses. Methods and Results Patients randomly assigned to dabigatran in RE-LY were eligible for the Long-term Multicenter Extension of Dabigatran Treatment in Patients with Atrial Fibrillation (RELY-ABLE) trial if they had not permanently discontinued study medication at the time of their final RE-LY study visit. Enrolled patients continued to receive the double-blind dabigatran dose received in RE-LY, for up to 28 months of follow up after RE-LY (median follow-up, 2.3 years). There were 5851 patients enrolled, representing 48% of patients originally randomly assigned to receive dabigatran in RE-LY and 86% of RELY-ABLE-eligible patients. Rates of stroke or systemic embolism were 1.46% and 1.60%/y on dabigatran 150 and 110 mg twice daily, respectively (hazard ratio, 0.91; 95% confidence interval, 0.69-1.20). Rates of major hemorrhage were 3.74% and 2.99%/y on dabigatran 150 and 110 mg (hazard ratio, 1.26; 95% confidence interval, 1.04-1.53). Rates of death were 3.02% and 3.10%/y (hazard ratio, 0.97; 95% confidence interval, 0.80-1.19). Rates of hemorrhagic stroke were 0.13% and 0.14%/y. Conclusions During 2.3 years of continued treatment with dabigatran after RE-LY, there was a higher rate of major bleeding with dabigatran 150 mg twice daily in comparison with 110 mg, and similar rates of stroke and death.
Keyword
- atrial fibrillation
- dabigatran
- hemorrhage
- stroke
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
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- By the author/editor
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Connolly, Stuart ...
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Wallentin, Lars
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Ezekowitz, Micha ...
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Eikelboom, John
-
Oldgren, Jonas
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Reilly, Paul A.
-
show more...
-
Brueckmann, Mart ...
-
Pogue, Janice
-
Alings, Marco
-
Amerena, John V.
-
Avezum, Alvaro
-
Baumgartner, Iri ...
-
Budaj, Andrzej J ...
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Chen, Jyh-Hong
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Dans, Antonio L.
-
Darius, Harald
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Di Pasquale, Giu ...
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Ferreira, Jorge
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Flaker, Greg C.
-
Flather, Marcus ...
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Franzosi, Maria ...
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Golitsyn, Sergey ...
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Halon, David A.
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Heidbuchel, Hein
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Hohnloser, Stefa ...
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Huber, Kurt
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Jansky, Petr
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Kamensky, Gabrie ...
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Keltai, Matyas
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Kim, Sung Soon
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Lau, Chu-Pak
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Le Heuzey, Jean- ...
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Lewis, Basil S.
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Liu, Lisheng
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Nanas, John
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Omar, Razali
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Pais, Prem
-
Pedersen, Knud E ...
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Piegas, Leopoldo ...
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Raev, Dimitar
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Smith, Pal J.
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Talajic, Mario
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Tan, Ru San
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Tanomsup, Supach ...
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Toivonen, Lauri
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Vinereanu, Drago ...
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Xavier, Denis
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Zhu, Jun
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Wang, Susan Q.
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Duffy, Christine ...
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Themeles, Elliso ...
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Yusuf, Salim
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show less...
- Articles in the publication
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Circulation
- By the university
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Uppsala University