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  • Andersen, Christen L.Dept Haematol, Roskilde Hosp, Roskilde, Denmark.; Dept Haematol, Copenhagen Univ Hosp, Rigshosp, Copenhagen, Denmark (author)

A phase II study of vorinostat (MK-0683) in patients with polycythaemia vera and essential thrombocythaemia

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • 2013-06-11
  • Wiley,2013
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-206429
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-206429URI
  • https://doi.org/10.1111/bjh.12416DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-56398URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:127078674URI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Inhibition of histone deacetylases may be an important target in patients with myeloproliferative neoplasms. This investigator-initiated, non-randomized, open-label phase II multi-centre study included 63 patients (19 essential thrombocythaemia, 44 polycythaemia vera) from 15 centres. The primary objective was to evaluate if vorinostat was followed by a decline in clonal myeloproliferation as defined by European Leukaemia Net. Thirty patients (48%) completed the intervention period (24 weeks of therapy). An intention-to-treat response rate of 35% was identified. Pruritus was resolved [19% to 0% (P=0.06)] and the prevalence of splenomegaly was lowered from 50% to 27% (P=0.03). Sixty-five per cent of the patients experienced a decrease in JAK2 V617F allele burden (P=0.006). Thirty-three patients (52% of patients) discontinued study drug before end of intervention due to adverse events (28 patients) or lack of response (5 patients). In conclusion, vorinostat showed effectiveness by normalizing elevated leucocyte and platelet counts, resolving pruritus and significantly reducing splenomegaly. However, vorinostat was associated with significant side effects resulting in a high discontinuation rate. A lower dose of vorinostat in combination with conventional and/or novel targeted therapies may be warranted in future studies.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • McMullin, Mary F.Dept Haematol, Queens Univ Belfast, Antrim, North Ireland (author)
  • Ejerblad, ElisabethUppsala universitet,Hematologi,Dept Haematol, Univ Uppsala Hosp, Uppsala, Sweden(Swepub:uu)eleje020 (author)
  • Zweegman, SonjaDept Haematol, Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands (author)
  • Harrison, ClaireDept Haematol, Guys & St Thomas Hosp, London, England; NHS Foundation Trust, London, England (author)
  • Fernandes, Savio (author)
  • Bareford, DavidDept Haematol, Russells Hall Hosp, Dudley, England (author)
  • Knapper, StevenDept Haematol, Cardiff Univ, Cardiff, S Glam, UK (author)
  • Samuelsson, JanKarolinska Institutet (author)
  • Loefvenberg, EvaHaematol Ctr, Karolinska Univ Hosp, Stockholm, Sweden (author)
  • Linder, Olle (author)
  • Andreasson, BjornDept Haematol, NU Hosp Org, Uddevalla Hosp, Uddevalla, Sweden (author)
  • Ahlstrand, ErikRegion Örebro län(Swepub:oru)ead (author)
  • Jensen, Morten K.Dept Haematol, Herlev Hosp, Herlev, Denmark (author)
  • Bjerrum, Ole W. (author)
  • Vestergaard, HanneDept Haematol, Odense Univ Hosp, Odense, Denmark (author)
  • Larsen, HerdisDept Internal Med, Dept Haematol, Viborg Hosp, Viborg, Denmark (author)
  • Klausen, Tobias W. (author)
  • Mourits-Andersen, TorbenDept Haematol, Esbjerg Cent Hosp, Esbjerg, Denmark (author)
  • Hasselbalch, Hans C.Dept Haematol, Roskilde Hosp, Roskilde, Denmark (author)
  • Dept Haematol, Roskilde Hosp, Roskilde, Denmark.; Dept Haematol, Copenhagen Univ Hosp, Rigshosp, Copenhagen, DenmarkDept Haematol, Queens Univ Belfast, Antrim, North Ireland (creator_code:org_t)

Related titles

  • In:British Journal of Haematology: Wiley162:4, s. 498-5080007-10481365-2141

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