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  • van der Veldt, Astrid A. M. (author)

Toward Prediction of Efficacy of Chemotherapy : A Proof of Concept Study in Lung Cancer Patients Using [11C]docetaxel and Positron Emission Tomography

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • 2013
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-206563
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-206563URI
  • https://doi.org/10.1158/1078-0432.CCR-12-3779DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Purpose:Pharmacokinetics of docetaxel can be measured in vivo using positron emission tomography (PET) and a microdose of radiolabeled docetaxel ([11C]docetaxel). The objective of this study was to investigate whether a [11C]docetaxel PET microdosing study could predict tumor uptake of therapeutic doses of docetaxel.Experimental Design:Docetaxel-naïve lung cancer patients underwent 2 [11C]docetaxel PET scans; one after bolus injection of [11C]docetaxel and another during combined infusion of [11C]docetaxel and a therapeutic dose of docetaxel (75 mg·m−2). Compartmental and spectral analyses were used to quantify [11C]docetaxel tumor kinetics. [11C]docetaxel PET measurements were used to estimate the area under the curve (AUC) of docetaxel in tumors. Tumor response was evaluated using computed tomography scans.Results:Net rates of influx (Ki) of [11C]docetaxel in tumors were comparable during microdosing and therapeutic scans. [11C]docetaxel AUCTumor during the therapeutic scan could be predicted reliably using an impulse response function derived from the microdosing scan together with the plasma curve of [11C]docetaxel during the therapeutic scan. At 90 minutes, the accumulated amount of docetaxel in tumors was less than 1% of the total infused dose of docetaxel. [11C]docetaxel Ki derived from the microdosing scan correlated with AUCTumor of docetaxel (Spearman ρ = 0.715; P = 0.004) during the therapeutic scan and with tumor response to docetaxel therapy (Spearman ρ = −0.800; P = 0.010).Conclusions:Microdosing data of [11C]docetaxel PET can be used to predict tumor uptake of docetaxel during chemotherapy. The present study provides a framework for investigating the PET microdosing concept for radiolabeled anticancer drugs in patients.

Added entries (persons, corporate bodies, meetings, titles ...)

  • Lubberink, MarkUppsala universitet,Enheten för nuklearmedicin och PET(Swepub:uu)marklubb (author)
  • Mathijssen, Ron H. J. (author)
  • Loos, Walter J. (author)
  • Herder, Gerarda J. M. (author)
  • Greuter, Henri N. (author)
  • Comans, Emile F. I. (author)
  • Rutten, Hugo B. (author)
  • Eriksson, JonasVU University Medical Center Amsterdam(Swepub:uu)joeri542 (author)
  • Windhorst, Albert D. (author)
  • Hendrikse, N. Harry (author)
  • Postmus, Pieter E. (author)
  • Smit, Egbert F. (author)
  • Lammertsma, Adriaan A. (author)
  • Uppsala universitetEnheten för nuklearmedicin och PET (creator_code:org_t)

Related titles

  • In:Clinical Cancer Research19:15, s. 4163-41731078-04321557-3265

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