Sökning: WFRF:(de Lange Elizabeth C)
> (2010-2014) >
[C-11]quinidine and...
-
Syvänen, StinaUppsala universitet,Geriatrik,Rudbeck Laboratory
(författare)
[C-11]quinidine and [C-11]laniquidar PET imaging in a chronic rodent epilepsy model : Impact of epilepsy and drug-responsiveness
- Artikel/kapitelEngelska2013
Förlag, utgivningsår, omfång ...
-
Elsevier BV,2013
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-207645
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-207645URI
-
https://doi.org/10.1016/j.nucmedbio.2013.05.008DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
Introduction: To analyse the impact of both epilepsy and pharmacological modulation of P-glycoprotein on brain uptake and kinetics of positron emission tomography (PET) radiotracers [C-11]quinidine and [C-11]laniquidar.Methods: Metabolism and brain kinetics of both [C-11]quinidine and [C-11]laniquidar were assessed in naive rats, electrode-implanted control rats, and rats with spontaneous recurrent seizures. The latter group was further classified according to their response to the antiepileptic drug phenobarbital into "responders" and "non-responders". Additional experiments were performed following pre-treatment with the P-glycoprotein modulator tariquidar.Results: [C-11]quinidine was metabolized rapidly, whereas [C-11]laniquidar was more stable. Brain concentrations of both radiotracers remained at relatively low levels at baseline conditions. Tariquidar pre-treatment resulted in significant increases of [C-11]quinidine and [C-11]laniquidar brain concentrations. In the epileptic subgroup "non-responders", brain uptake of [C-11]quinidine in selected brain regions reached higher levels than in electrode-implanted control rats. However, the relative response to tariquidar did not differ between groups with full blockade of P-glycoprotein by 15 mg/kg of tariquidar. For [C-11]laniquidar differences between epileptic and control animals were only evident at baseline conditions but not after tariquidar pretreatment.Conclusions: We confirmed that both [C-11]quinidine and [C-11]laniquidar are P-glycoprotein substrates. At full P-gp blockade, tariquidar pre-treatment only demonstrated slight differences for [C-11]quinidine between drug-resistant and drug-sensitive animals.
Ämnesord och genrebeteckningar
-
Positron emission tomography
-
[C-11]quinidine
-
[C-11]laniquidar
-
P-glycoprotein
-
Epilepsy
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Russmann, Vera
(författare)
-
Verbeek, Joost
(författare)
-
Eriksson, JonasDepartment of Nuclear Medicine & PET Research, VU University Medical Center, Amsterdam, The Netherlands(Swepub:uu)joeri542
(författare)
-
Labots, Maaike
(författare)
-
Zellinger, Christina
(författare)
-
Seeger, Natalie
(författare)
-
Schuit, Robert
(författare)
-
Rongen, Marissa
(författare)
-
van Kooij, Rolph
(författare)
-
Windhorst, Albert D.
(författare)
-
Lammertsma, Adriaan A.
(författare)
-
de Lange, Elizabeth C.
(författare)
-
Voskuyl, Rob A.
(författare)
-
Koepp, Matthias
(författare)
-
Potschka, Heidrun
(författare)
-
Uppsala universitetGeriatrik
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Nuclear Medicine and Biology: Elsevier BV40:6, s. 764-7750969-80511872-9614
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Syvänen, Stina
-
Russmann, Vera
-
Verbeek, Joost
-
Eriksson, Jonas
-
Labots, Maaike
-
Zellinger, Chris ...
-
visa fler...
-
Seeger, Natalie
-
Schuit, Robert
-
Rongen, Marissa
-
van Kooij, Rolph
-
Windhorst, Alber ...
-
Lammertsma, Adri ...
-
de Lange, Elizab ...
-
Voskuyl, Rob A.
-
Koepp, Matthias
-
Potschka, Heidru ...
-
visa färre...
- Artiklar i publikationen
-
Nuclear Medicine ...
- Av lärosätet
-
Uppsala universitet