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Quantification of t...
Quantification of total and visceral adipose tissue in fructose-fed rats using water-fat separated single echo MRI
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- Rönn, Monika (author)
- Uppsala universitet,Arbets- och miljömedicin,Uppsala University, Sweden
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- Lind, Monica P. (author)
- Uppsala universitet,Arbets- och miljömedicin,Uppsala University, Sweden
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- Karlsson, Helen (author)
- Östergötlands Läns Landsting,Linköpings universitet,Arbets- och miljövetenskap,Hälsouniversitetet,Arbets- och miljömedicin
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- Cvek, Katarina (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences,The Swedish university of Agricultural Science, Uppsala, Sweden
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- Berglund, Johan (author)
- Uppsala universitet,Enheten för radiologi,Uppsala University, Sweden
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- Malmberg, Filip (author)
- Uppsala universitet,Bildanalys och människa-datorinteraktion,Avdelningen för visuell information och interaktion,Uppsala University, Sweden
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- Örberg, Jan (author)
- Uppsala universitet,Miljötoxikologi,Uppsala University, Sweden
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi,Uppsala University, Sweden
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- Ortiz-Nieto, Francisco (author)
- Uppsala universitet,Enheten för radiologi
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- Kullberg, Joel (author)
- Uppsala universitet,Enheten för radiologi,Uppsala University, Sweden
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(creator_code:org_t)
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- 2013-05-21
- 2013
- English.
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In: Obesity. - : Wiley. - 1930-7381 .- 1930-739X. ; 21:9, s. E388-E395
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Abstract
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- Objective: The aim of this study was to setup a rodent model for modest weight gain and an MRI-based quantification of body composition on a clinical 1.5 T MRI system for studies of obesity and environmental factors and their possible association. Design and Methods: Twenty-four 4-week-old female Fischer rats were divided into two groups: one exposed group (n=12) and one control group (n 12). The exposed group was given drinking water containing fructose (5% for 7 weeks, then 20% for 3 weeks). The control group was given tap water. Before sacrifice, whole body MRI was performed to determine volumes of total and visceral adipose tissue and lean tissue. MRI was performed using a clinical 1.5 T system and a chemical shift based technique for separation of water and fat signal from a rapid single echo acquisition. Fat signal fraction was used to separate adipose and lean tissue. Visceral adipose tissue volume was quantified using semiautomated segmentation. After sacrifice, a perirenal fat pad and the liver were dissected and weighed. Plasma proteins were analyzed by Western blot. Results: The weight gain was 5.2% greater in rats exposed to fructose than in controls (P=0.042). Total and visceral adipose tissue volumes were 5.2 cm(3) (P=0.017) and 3.1 cm(3) (P=0.019) greater, respectively, while lean tissue volumes did not differ. The level of triglycerides and apolipoprotein A-I was higher (P=0.034, P=0.005, respectively) in fructose-exposed rats.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Medicinteknik -- Medicinsk bildbehandling (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Medical Engineering -- Medical Image Processing (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Obesity
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To the university's database
- By the author/editor
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Rönn, Monika
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Lind, Monica P.
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Karlsson, Helen
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Cvek, Katarina
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Berglund, Johan
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Malmberg, Filip
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show more...
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Örberg, Jan
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Lind, Lars
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Ortiz-Nieto, Fra ...
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Kullberg, Joel
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- About the subject
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Medical Engineer ...
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and Medical Image Pr ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
- Articles in the publication
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Obesity
- By the university
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Uppsala University
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Swedish University of Agricultural Sciences
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Linköping University