Search: (WFRF:(Kaprio Jaakko)) pers:(Lind Lars) pers:(Gudnason Vilmundur) >
Common variants ass...
Common variants associated with plasma triglycerides and risk for coronary artery disease
- Article/chapterEnglish2013
Publisher, publication year, extent ...
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2013-10-06
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Springer Science and Business Media LLC,2013
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-211785
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-211785URI
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https://doi.org/10.1038/ng.2795DOI
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https://lup.lub.lu.se/record/4204844URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:127684108URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-83627URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 x 10(-8) for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.
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Willer, Cristen J.
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Schmidt, Ellen M.
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Sengupta, Sebanti
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Gao, Chi
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Peloso, Gina M.
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Gustafsson, StefanUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)stegu732
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Kanoni, Stavroula
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Ganna, AndreaKarolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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Chen, Jin
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Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind
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Mora, Samia
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Beckmann, Jacques S.
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Bragg-Gresham, Jennifer L.
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Chang, Hsing-Yi
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Demirkan, Ayse
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Donnelly, Louise A.
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Ehret, Georg B.
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Esko, Tonu
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Feitosa, Mary F.
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Ferreira, Teresa
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Fischer, Krista
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Fontanillas, Pierre
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Fraser, Ross M.
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Freitag, Daniel F.
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Gurdasani, Deepti
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Heikkila, Kauko
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Hyppoenen, Elina
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Isaacs, Aaron
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Jackson, Anne U.
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Johansson, ÅsaUppsala universitet,Genomik,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)asjoh108
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Johnson, Toby
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Kaakinen, Marika
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Kettunen, Johannes
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Kleber, Marcus E.
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Li, Xiaohui
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Luan, Jian'an
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Lyytikainen, Leo-Pekka
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Magnusson, Patrik K. E.Karolinska Institutet
(author)
-
Mangino, Massimo
(author)
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Mihailov, Evelin
(author)
-
Montasser, May E.
(author)
-
Mueller-Nurasyid, Martina
(author)
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Nolte, Ilja M.
(author)
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O'Connell, Jeffrey R.
(author)
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Palmer, Cameron D.
(author)
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Perola, Markus
(author)
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Petersen, Ann-Kristin
(author)
-
Sanna, Serena
(author)
-
Saxena, Richa
(author)
-
Service, Susan K.
(author)
-
Shah, Sonia
(author)
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Shungin, DmitryUmeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Medicin,Institutionen för odontologi(Swepub:umu)dmsh0003
(author)
-
Sidore, Carlo
(author)
-
Song, CiKarolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ciaso492
(author)
-
Strawbridge, Rona J.Karolinska Institutet
(author)
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Surakka, Ida
(author)
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Tanaka, Toshiko
(author)
-
Teslovich, Tanya M.
(author)
-
Thorleifsson, Gudmar
(author)
-
Van den Herik, Evita G.
(author)
-
Voight, Benjamin F.
(author)
-
Volcik, Kelly A.
(author)
-
Waite, Lindsay L.
(author)
-
Wong, Andrew
(author)
-
Wu, Ying
(author)
-
Zhang, Weihua
(author)
-
Absher, Devin
(author)
-
Asiki, Gershim
(author)
-
Barroso, Ines
(author)
-
Been, Latonya F.
(author)
-
Bolton, Jennifer L.
(author)
-
Bonnycastle, Lori L.
(author)
-
Brambilla, Paolo
(author)
-
Burnett, Mary S.
(author)
-
Cesana, Giancarlo
(author)
-
Dimitriou, Maria
(author)
-
Doney, Alex S. F.
(author)
-
Doering, Angela
(author)
-
Elliott, Paul
(author)
-
Epstein, Stephen E.
(author)
-
Eyjolfsson, Gudmundur Ingi
(author)
-
Gigante, BrunaKarolinska Institutet
(author)
-
Goodarzi, Mark O.
(author)
-
Grallert, Harald
(author)
-
Gravito, Martha L.
(author)
-
Groves, Christopher J.
(author)
-
Hallmans, GöranUmeå universitet,Näringsforskning(Swepub:umu)goha0001
(author)
-
Hartikainen, Anna-Liisa
(author)
-
Hayward, Caroline
(author)
-
Hernandez, Dena
(author)
-
Hicks, Andrew A.
(author)
-
Holm, Hilma
(author)
-
Hung, Yi-Jen
(author)
-
Illig, Thomas
(author)
-
Jones, Michelle R.
(author)
-
Kaleebu, Pontiano
(author)
-
Kastelein, John J. P.
(author)
-
Khaw, Kay-Tee
(author)
-
Kim, Eric
(author)
-
Klopp, Norman
(author)
-
Komulainen, Pirjo
(author)
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Kumari, Meena
(author)
-
Langenberg, Claudia
(author)
-
Lehtimaki, Terho
(author)
-
Lin, Shih-Yi
(author)
-
Lindstrom, Jaana
(author)
-
Loos, Ruth J. F.
(author)
-
Mach, Francois
(author)
-
McArdle, Wendy L.
(author)
-
Meisinger, Christa
(author)
-
Mitchell, Braxton D.
(author)
-
Mueller, Gabrielle
(author)
-
Nagaraja, Ramaiah
(author)
-
Narisu, NarisuKarolinska Institutet
(author)
-
Nieminen, Tuomo V. M.
(author)
-
Nsubuga, Rebecca N.
(author)
-
Olafsson, Isleifur
(author)
-
Ong, Ken K.
(author)
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Palotie, Aarno
(author)
-
Papamarkou, Theodore
(author)
-
Pomilla, Cristina
(author)
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Pouta, Anneli
(author)
-
Rader, Daniel J.
(author)
-
Reilly, Muredach P.
(author)
-
Ridker, Paul M.
(author)
-
Rivadeneira, Fernando
(author)
-
Rudan, Igor
(author)
-
Ruokonen, Aimo
(author)
-
Samani, Nilesh
(author)
-
Scharnagl, Hubert
(author)
-
Seeley, Janet
(author)
-
Silander, Kaisa
(author)
-
Stancakova, Alena
(author)
-
Stirrups, Kathleen
(author)
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Swift, Amy J.
(author)
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Tiret, Laurence
(author)
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Uitterlinden, Andre G.
(author)
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van Pelt, L. Joost
(author)
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Vedantam, Sailaja
(author)
-
Wainwright, Nicholas
(author)
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Wijmenga, Cisca
(author)
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Wild, Sarah H.
(author)
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Willemsen, Gonneke
(author)
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Wilsgaard, Tom
(author)
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Wilson, James F.
(author)
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Young, Elizabeth H.
(author)
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Zhao, Jing Hua
(author)
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Adair, Linda S.
(author)
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Arveiler, Dominique
(author)
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Assimes, Themistocles L.
(author)
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Bandinelli, Stefania
(author)
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Bennett, Franklyn
(author)
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Bochud, Murielle
(author)
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Boehm, Bernhard O.
(author)
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Boomsma, Dorret I.
(author)
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Borecki, Ingrid B.
(author)
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Bornstein, Stefan R.
(author)
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Bovet, Pascal
(author)
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Burnier, Michel
(author)
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Campbell, Harry
(author)
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Chakravarti, Aravinda
(author)
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Chambers, John C.
(author)
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Chen, Yii-Der Ida
(author)
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Collins, Francis S.
(author)
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Cooper, Richard S.
(author)
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Danesh, John
(author)
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Dedoussis, George
(author)
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de Faire, UlfKarolinska Institutet
(author)
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Feranil, Alan B.
(author)
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Ferrieres, Jean
(author)
-
Ferrucci, Luigi
(author)
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Freimer, Nelson B.
(author)
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Gieger, Christian
(author)
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Groop, LeifLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-lgr
(author)
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Gudnason, Vilmundur
(author)
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Gyllensten, UlfUppsala universitet,Genomik,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)ulfgyll
(author)
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Hamsten, AndersKarolinska Institutet
(author)
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Harris, Tamara B.
(author)
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Hingorani, Aroon
(author)
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Hirschhorn, Joel N.
(author)
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Hofman, Albert
(author)
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Hovingh, G. Kees
(author)
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Hsiung, Chao Agnes
(author)
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Humphries, Steve E.
(author)
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Hunt, Steven C.
(author)
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Hveem, Kristian
(author)
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Iribarren, Carlos
(author)
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Jarvelin, Marjo-Riitta
(author)
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Jula, Antti
(author)
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Kahonen, Mika
(author)
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Kaprio, Jaakko
(author)
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Kesaniemi, Antero
(author)
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Kivimaki, Mika
(author)
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Kooner, Jaspal S.
(author)
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Koudstaal, Peter J.
(author)
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Krauss, Ronald M.
(author)
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Kuh, Diana
(author)
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Kuusisto, Johanna
(author)
-
Kyvik, Kirsten O.
(author)
-
Laakso, Markku
(author)
-
Lakka, Timo A.
(author)
-
Lind, LarsUppsala universitet,Kardiovaskulär epidemiologi(Swepub:uu)larslind
(author)
-
Lindgren, Cecilia M.
(author)
-
Martin, Nicholas G.
(author)
-
Maerz, Winfried
(author)
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McCarthy, Mark I.
(author)
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McKenzie, Colin A.
(author)
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Meneton, Pierre
(author)
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Metspalu, Andres
(author)
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Moilanen, Leena
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Morris, Andrew D.
(author)
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Munroe, Patricia B.
(author)
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Njolstad, Inger
(author)
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Pedersen, Nancy L.
(author)
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Power, Chris
(author)
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Pramstaller, Peter P.
(author)
-
Price, Jackie F.
(author)
-
Psaty, Bruce M.
(author)
-
Quertermous, Thomas
(author)
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Rauramaa, Rainer
(author)
-
Saleheen, Danish
(author)
-
Salomaa, Veikko
(author)
-
Sanghera, Dharambir K.
(author)
-
Saramies, Jouko
(author)
-
Schwarz, Peter E. H.
(author)
-
Sheu, Wayne H-H
(author)
-
Shuldiner, Alan R.
(author)
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Siegbahn, AgnetaUppsala universitet,Molekylär epidemiologi,Uppsala kliniska forskningscentrum (UCR),Koagulation och inflammationsvetenskap(Swepub:uu)agsie424
(author)
-
Spector, Tim D.
(author)
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Stefansson, Kari
(author)
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Strachan, David P.
(author)
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Tayo, Bamidele O.
(author)
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Tremoli, Elena
(author)
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Tuomilehto, Jaakko
(author)
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Uusitupa, Matti
(author)
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van Duijn, Cornelia M.
(author)
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Vollenweider, Peter
(author)
-
Wallentin, LarsUppsala universitet,Kardiologi(Swepub:uu)larswall
(author)
-
Wareham, Nicholas J.
(author)
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Whitfield, John B.
(author)
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Wolffenbuttel, Bruce H. R.
(author)
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Altshuler, David
(author)
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Ordovas, Jose M.
(author)
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Boerwinkle, Eric
(author)
-
Palmer, Colin N. A.
(author)
-
Thorsteinsdottir, Unnur
(author)
-
Chasman, Daniel I.
(author)
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Rotter, Jerome I.
(author)
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Franks, PaulUmeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Medicin,Lunds universitet, Harvard University(Swepub:umu)pafr0003
(author)
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Ripatti, Samuli
(author)
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Cupples, L. Adrienne
(author)
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Sandhu, Manjinder S.
(author)
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Rich, Stephen S.
(author)
-
Boehnke, Michael
(author)
-
Deloukas, Panos
(author)
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Mohlke, Karen L.
(author)
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Ingelsson, ErikUppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)ering425
(author)
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Abecasis, Goncalo R.
(author)
-
Daly, Mark J.
(author)
-
Neale, Benjamin M.
(author)
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Kathiresan, Sekar
(author)
-
Uppsala universitetMolekylär epidemiologi
(creator_code:org_t)
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In:Nature Genetics: Springer Science and Business Media LLC45:11, s. 1345-+1061-40361546-1718
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Saramies, Jouko
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Schwarz, Peter E ...
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Sheu, Wayne H-H
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Shuldiner, Alan ...
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Siegbahn, Agneta
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Spector, Tim D.
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Stefansson, Kari
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Strachan, David ...
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Tayo, Bamidele O ...
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Tremoli, Elena
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Tuomilehto, Jaak ...
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Uusitupa, Matti
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van Duijn, Corne ...
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Vollenweider, Pe ...
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Wallentin, Lars
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Wareham, Nichola ...
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Whitfield, John ...
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Wolffenbuttel, B ...
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Altshuler, David
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Ordovas, Jose M.
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Boerwinkle, Eric
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Palmer, Colin N. ...
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Thorsteinsdottir ...
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Chasman, Daniel ...
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Rotter, Jerome I ...
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Franks, Paul
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Ripatti, Samuli
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Cupples, L. Adri ...
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Sandhu, Manjinde ...
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Rich, Stephen S.
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Boehnke, Michael
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Deloukas, Panos
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Mohlke, Karen L.
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Ingelsson, Erik
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Abecasis, Goncal ...
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Daly, Mark J.
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Neale, Benjamin ...
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Kathiresan, Seka ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Nature Genetics
- By the university
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Uppsala University
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Lund University
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Karolinska Institutet
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Umeå University