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  • Tomassen, P. (author)

Staphylococcus aureus enterotoxin-specific IgE is associated with asthma in the general population : a GA(2)LEN study

  • Article/chapterEnglish2013

Publisher, publication year, extent ...

  • 2013-10-05
  • Wiley,2013
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-212343
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-212343URI
  • https://doi.org/10.1111/all.12230DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-81580URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:127697551URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • De två (2) första författarna delar förstaförfattarskapet.
  • BackgroundSpecific IgE to Staphylococcus aureus enterotoxins (SE-IgE) has been associated with asthma. In the general population, we aimed to determine the prevalence of and risk factors for serum SE-IgE and to examine the association with asthma.MethodsA postal questionnaire was sent to a random sample of adults in 19 centers across Europe. A random sample of respondents was invited for clinical examination upon which they answered a questionnaire, underwent skin prick tests (SPTs) for common aeroallergens, and provided blood for measurement of total IgE and SE-IgE. Risks were analyzed within centers using weighted logistic regression, and overall estimates calculated using fixed-effects meta-analysis.Results2908 subjects were included in this analysis. Prevalence of positive SE-IgE was 29.3%; no significant geographic variation was observed. In contrast to positive skin prick tests, SE-IgE was more common in smokers (<15 pack-year: OR 1.11, P=0.079, 15 pack-year: OR 1.70, P<0.001), and prevalence did not decrease in older age-groups or in those with many siblings. Total IgE concentrations were higher in those with positive SE-IgE than in those with positive SPT. SE-IgE was associated with asthma (OR 2.10, 95% confidence interval [1.60-2.76], P=0.001) in a concentration-dependent manner. This effect was independent of SPT result and homogeneous across all centers.ConclusionsWe report for the first time that SE-IgE is common in the general population throughout Europe and that its risk factors differ from those of IgE against aeroallergens. This is the first study to show that SE-IgE is significantly and independently associated with asthma in the general population.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Jarvis, D. (author)
  • Newson, R. (author)
  • Van Ree, R. (author)
  • Forsberg, BertilUmeå universitet,Yrkes- och miljömedicin(Swepub:umu)befo0001 (author)
  • Howarth, P. (author)
  • Janson, ChristerUppsala universitet,Lungmedicin och allergologi(Swepub:uu)chrisjn (author)
  • Kowalski, M. L. (author)
  • Kraemer, U. (author)
  • Matricardi, P. M. (author)
  • Middelveld, R. J. M.Karolinska Institutet (author)
  • Todo-Bom, A. (author)
  • Toskala, E. (author)
  • Thilsing, T. (author)
  • Brozek, G. (author)
  • Van Drunen, C. (author)
  • Burney, P. (author)
  • Bachert, C.Karolinska Institutet (author)
  • Umeå universitetYrkes- och miljömedicin (creator_code:org_t)

Related titles

  • In:Allergy. European Journal of Allergy and Clinical Immunology: Wiley68:10, s. 1289-12970105-45381398-9995

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